Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus

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Standard

Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus. / Hageman, I; Nielsen, M; Wörtwein, Gitta; Diemer, N H; Jorgensen, M B.

In: Stress: The International Journal on the Biology of Stress , Vol. 11, No. 4, 2008, p. 282-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hageman, I, Nielsen, M, Wörtwein, G, Diemer, NH & Jorgensen, MB 2008, 'Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus', Stress: The International Journal on the Biology of Stress , vol. 11, no. 4, pp. 282-9. https://doi.org/10.1080/10253890701783794

APA

Hageman, I., Nielsen, M., Wörtwein, G., Diemer, N. H., & Jorgensen, M. B. (2008). Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus. Stress: The International Journal on the Biology of Stress , 11(4), 282-9. https://doi.org/10.1080/10253890701783794

Vancouver

Hageman I, Nielsen M, Wörtwein G, Diemer NH, Jorgensen MB. Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus. Stress: The International Journal on the Biology of Stress . 2008;11(4):282-9. https://doi.org/10.1080/10253890701783794

Author

Hageman, I ; Nielsen, M ; Wörtwein, Gitta ; Diemer, N H ; Jorgensen, M B. / Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus. In: Stress: The International Journal on the Biology of Stress . 2008 ; Vol. 11, No. 4. pp. 282-9.

Bibtex

@article{2a0171f0eba211ddbf70000ea68e967b,
title = "Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus",
abstract = "Stress can precipitate major depression and other disorders linked to hippocampal shrinkage. It is hypothesized but not established that treatment of these disorders reverses and prevents the hippocampal changes. Dendritic retraction of individual neurons might in concert with other pathophysiological events contribute to the shrinkage phenomenon. Animal studies have shown that various stress paradigms can induce dendritic retraction in the CA3 pyramidal neurons of the hippocampus. Since electroconvulsive treatment is the most effective treatment in humans with major depression, we investigated whether repeated electroconvulsive stimulations (ECSs) could influence such changes in stressed rats. Furthermore, we investigated whether ECSs per se could influence neuronal branching and total length of the CA3 hippocampal neuronal dendritic tree in normal rats. Rats were stressed using the 21-day 6 h daily restraint stress paradigm. The study shows that stress caused remodelling of the pyramidal neurons by significantly reducing the number of dendritic branch points and total length of the apical dendritic tree. Concomitant administration of ECSs prevented these effects. ECSs had no effect on pyramidal neuron dendrites in normal rats.",
author = "I Hageman and M Nielsen and Gitta W{\"o}rtwein and Diemer, {N H} and Jorgensen, {M B}",
note = "Keywords: Animals; Dendrites; Electric Stimulation; Hippocampus; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological",
year = "2008",
doi = "10.1080/10253890701783794",
language = "English",
volume = "11",
pages = "282--9",
journal = "Stress: The International Journal on the Biology of Stress",
issn = "1025-3890",
publisher = "Taylor & Francis",
number = "4",

}

RIS

TY - JOUR

T1 - Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus

AU - Hageman, I

AU - Nielsen, M

AU - Wörtwein, Gitta

AU - Diemer, N H

AU - Jorgensen, M B

N1 - Keywords: Animals; Dendrites; Electric Stimulation; Hippocampus; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological

PY - 2008

Y1 - 2008

N2 - Stress can precipitate major depression and other disorders linked to hippocampal shrinkage. It is hypothesized but not established that treatment of these disorders reverses and prevents the hippocampal changes. Dendritic retraction of individual neurons might in concert with other pathophysiological events contribute to the shrinkage phenomenon. Animal studies have shown that various stress paradigms can induce dendritic retraction in the CA3 pyramidal neurons of the hippocampus. Since electroconvulsive treatment is the most effective treatment in humans with major depression, we investigated whether repeated electroconvulsive stimulations (ECSs) could influence such changes in stressed rats. Furthermore, we investigated whether ECSs per se could influence neuronal branching and total length of the CA3 hippocampal neuronal dendritic tree in normal rats. Rats were stressed using the 21-day 6 h daily restraint stress paradigm. The study shows that stress caused remodelling of the pyramidal neurons by significantly reducing the number of dendritic branch points and total length of the apical dendritic tree. Concomitant administration of ECSs prevented these effects. ECSs had no effect on pyramidal neuron dendrites in normal rats.

AB - Stress can precipitate major depression and other disorders linked to hippocampal shrinkage. It is hypothesized but not established that treatment of these disorders reverses and prevents the hippocampal changes. Dendritic retraction of individual neurons might in concert with other pathophysiological events contribute to the shrinkage phenomenon. Animal studies have shown that various stress paradigms can induce dendritic retraction in the CA3 pyramidal neurons of the hippocampus. Since electroconvulsive treatment is the most effective treatment in humans with major depression, we investigated whether repeated electroconvulsive stimulations (ECSs) could influence such changes in stressed rats. Furthermore, we investigated whether ECSs per se could influence neuronal branching and total length of the CA3 hippocampal neuronal dendritic tree in normal rats. Rats were stressed using the 21-day 6 h daily restraint stress paradigm. The study shows that stress caused remodelling of the pyramidal neurons by significantly reducing the number of dendritic branch points and total length of the apical dendritic tree. Concomitant administration of ECSs prevented these effects. ECSs had no effect on pyramidal neuron dendrites in normal rats.

U2 - 10.1080/10253890701783794

DO - 10.1080/10253890701783794

M3 - Journal article

C2 - 18574788

VL - 11

SP - 282

EP - 289

JO - Stress: The International Journal on the Biology of Stress

JF - Stress: The International Journal on the Biology of Stress

SN - 1025-3890

IS - 4

ER -

ID: 9938118