Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus. / Hageman, I; Nielsen, M; Wörtwein, Gitta; Diemer, N H; Jorgensen, M B.
In: Stress: The International Journal on the Biology of Stress , Vol. 11, No. 4, 2008, p. 282-9.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus
AU - Hageman, I
AU - Nielsen, M
AU - Wörtwein, Gitta
AU - Diemer, N H
AU - Jorgensen, M B
N1 - Keywords: Animals; Dendrites; Electric Stimulation; Hippocampus; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological
PY - 2008
Y1 - 2008
N2 - Stress can precipitate major depression and other disorders linked to hippocampal shrinkage. It is hypothesized but not established that treatment of these disorders reverses and prevents the hippocampal changes. Dendritic retraction of individual neurons might in concert with other pathophysiological events contribute to the shrinkage phenomenon. Animal studies have shown that various stress paradigms can induce dendritic retraction in the CA3 pyramidal neurons of the hippocampus. Since electroconvulsive treatment is the most effective treatment in humans with major depression, we investigated whether repeated electroconvulsive stimulations (ECSs) could influence such changes in stressed rats. Furthermore, we investigated whether ECSs per se could influence neuronal branching and total length of the CA3 hippocampal neuronal dendritic tree in normal rats. Rats were stressed using the 21-day 6 h daily restraint stress paradigm. The study shows that stress caused remodelling of the pyramidal neurons by significantly reducing the number of dendritic branch points and total length of the apical dendritic tree. Concomitant administration of ECSs prevented these effects. ECSs had no effect on pyramidal neuron dendrites in normal rats.
AB - Stress can precipitate major depression and other disorders linked to hippocampal shrinkage. It is hypothesized but not established that treatment of these disorders reverses and prevents the hippocampal changes. Dendritic retraction of individual neurons might in concert with other pathophysiological events contribute to the shrinkage phenomenon. Animal studies have shown that various stress paradigms can induce dendritic retraction in the CA3 pyramidal neurons of the hippocampus. Since electroconvulsive treatment is the most effective treatment in humans with major depression, we investigated whether repeated electroconvulsive stimulations (ECSs) could influence such changes in stressed rats. Furthermore, we investigated whether ECSs per se could influence neuronal branching and total length of the CA3 hippocampal neuronal dendritic tree in normal rats. Rats were stressed using the 21-day 6 h daily restraint stress paradigm. The study shows that stress caused remodelling of the pyramidal neurons by significantly reducing the number of dendritic branch points and total length of the apical dendritic tree. Concomitant administration of ECSs prevented these effects. ECSs had no effect on pyramidal neuron dendrites in normal rats.
U2 - 10.1080/10253890701783794
DO - 10.1080/10253890701783794
M3 - Journal article
C2 - 18574788
VL - 11
SP - 282
EP - 289
JO - Stress: The International Journal on the Biology of Stress
JF - Stress: The International Journal on the Biology of Stress
SN - 1025-3890
IS - 4
ER -
ID: 9938118