Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis

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Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis. / Bräuner, Elvira V.; Lim, Youn-Hee; Koch, Trine; Uldbjerg, Cecilie S; Gregersen, Laura S; Pedersen, Marc K; Frederiksen, Hanne; Petersen, Jørgen H.; Coull, Brent A; Andersson, Anna-Maria; Hickey, Martha; Skakkebæk, Niels E; Hauser, Russ; Juul, Anders.

In: The Journal of clinical endocrinology and metabolism, 16.07.2021.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bräuner, EV, Lim, Y-H, Koch, T, Uldbjerg, CS, Gregersen, LS, Pedersen, MK, Frederiksen, H, Petersen, JH, Coull, BA, Andersson, A-M, Hickey, M, Skakkebæk, NE, Hauser, R & Juul, A 2021, 'Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis', The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/clinem/dgab523

APA

Bräuner, E. V., Lim, Y-H., Koch, T., Uldbjerg, C. S., Gregersen, L. S., Pedersen, M. K., Frederiksen, H., Petersen, J. H., Coull, B. A., Andersson, A-M., Hickey, M., Skakkebæk, N. E., Hauser, R., & Juul, A. (2021). Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis. The Journal of clinical endocrinology and metabolism. https://doi.org/10.1210/clinem/dgab523

Vancouver

Bräuner EV, Lim Y-H, Koch T, Uldbjerg CS, Gregersen LS, Pedersen MK et al. Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis. The Journal of clinical endocrinology and metabolism. 2021 Jul 16. https://doi.org/10.1210/clinem/dgab523

Author

Bräuner, Elvira V. ; Lim, Youn-Hee ; Koch, Trine ; Uldbjerg, Cecilie S ; Gregersen, Laura S ; Pedersen, Marc K ; Frederiksen, Hanne ; Petersen, Jørgen H. ; Coull, Brent A ; Andersson, Anna-Maria ; Hickey, Martha ; Skakkebæk, Niels E ; Hauser, Russ ; Juul, Anders. / Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis. In: The Journal of clinical endocrinology and metabolism. 2021.

Bibtex

@article{c8b0d3fff6544a7fad9c25beb3f1ea9a,
title = "Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis",
abstract = "The incidence of many hormone-dependent diseases, including testicular cancer, have sharply increased in all high-income countries during the 20th century. This is not fully explained by established risk factors. Concurrent, increasing exposure to antiandrogenic environmental endocrine disrupting chemicals (EDCs) in fetal life may partially explain this trend. This systematic review assessed available evidence regarding the association between environmental EDC exposure and risk of testicular cancer (seminomas and non-seminomas). Following PRISMA guidelines, a search of English peer-reviewed literature published prior to December 14 th, 2020, in the databases PubMed and Embase{\textregistered} was performed. Among the 279 identified records, 19 were eligible for quality assessment and 10 for further meta-analysis. The completeness of reporting was high across papers, but over 50% were considered subject to potential risk of bias. Mean age at diagnosis was 31.9 years. None considered effects of EDCs multipollutant mixtures. The meta-analyses showed that maternal exposure to combined EDCs was associated with a higher risk of testicular cancer in male offspring (summary RRs: 2.16, (95% CI:1.78-2.62); 1.93 (95% CI:1.49-2.48); 2.78 (95% CI:2.27-3.41) for all, seminoma, non-seminoma respectively). Similarly, high maternal exposures to grouped organochlorines and organo-halogens were associated with higher risk of seminoma and non-seminoma in the offspring. Summary estimates related to postnatal adult male EDC exposures were inconsistent.Maternal but not postnatal adult male, EDC exposures were consistently associated with a higher risk of testicular cancer, particularly risk of non-seminomas. However, the quality of studies was mixed and considering the fields complexity, more prospective studies of prenatal EDC multipollutant mixture exposures and testicular cancer are needed.",
author = "Br{\"a}uner, {Elvira V.} and Youn-Hee Lim and Trine Koch and Uldbjerg, {Cecilie S} and Gregersen, {Laura S} and Pedersen, {Marc K} and Hanne Frederiksen and Petersen, {J{\o}rgen H.} and Coull, {Brent A} and Anna-Maria Andersson and Martha Hickey and Skakkeb{\ae}k, {Niels E} and Russ Hauser and Anders Juul",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2021",
month = jul,
day = "16",
doi = "10.1210/clinem/dgab523",
language = "English",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis

AU - Bräuner, Elvira V.

AU - Lim, Youn-Hee

AU - Koch, Trine

AU - Uldbjerg, Cecilie S

AU - Gregersen, Laura S

AU - Pedersen, Marc K

AU - Frederiksen, Hanne

AU - Petersen, Jørgen H.

AU - Coull, Brent A

AU - Andersson, Anna-Maria

AU - Hickey, Martha

AU - Skakkebæk, Niels E

AU - Hauser, Russ

AU - Juul, Anders

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2021/7/16

Y1 - 2021/7/16

N2 - The incidence of many hormone-dependent diseases, including testicular cancer, have sharply increased in all high-income countries during the 20th century. This is not fully explained by established risk factors. Concurrent, increasing exposure to antiandrogenic environmental endocrine disrupting chemicals (EDCs) in fetal life may partially explain this trend. This systematic review assessed available evidence regarding the association between environmental EDC exposure and risk of testicular cancer (seminomas and non-seminomas). Following PRISMA guidelines, a search of English peer-reviewed literature published prior to December 14 th, 2020, in the databases PubMed and Embase® was performed. Among the 279 identified records, 19 were eligible for quality assessment and 10 for further meta-analysis. The completeness of reporting was high across papers, but over 50% were considered subject to potential risk of bias. Mean age at diagnosis was 31.9 years. None considered effects of EDCs multipollutant mixtures. The meta-analyses showed that maternal exposure to combined EDCs was associated with a higher risk of testicular cancer in male offspring (summary RRs: 2.16, (95% CI:1.78-2.62); 1.93 (95% CI:1.49-2.48); 2.78 (95% CI:2.27-3.41) for all, seminoma, non-seminoma respectively). Similarly, high maternal exposures to grouped organochlorines and organo-halogens were associated with higher risk of seminoma and non-seminoma in the offspring. Summary estimates related to postnatal adult male EDC exposures were inconsistent.Maternal but not postnatal adult male, EDC exposures were consistently associated with a higher risk of testicular cancer, particularly risk of non-seminomas. However, the quality of studies was mixed and considering the fields complexity, more prospective studies of prenatal EDC multipollutant mixture exposures and testicular cancer are needed.

AB - The incidence of many hormone-dependent diseases, including testicular cancer, have sharply increased in all high-income countries during the 20th century. This is not fully explained by established risk factors. Concurrent, increasing exposure to antiandrogenic environmental endocrine disrupting chemicals (EDCs) in fetal life may partially explain this trend. This systematic review assessed available evidence regarding the association between environmental EDC exposure and risk of testicular cancer (seminomas and non-seminomas). Following PRISMA guidelines, a search of English peer-reviewed literature published prior to December 14 th, 2020, in the databases PubMed and Embase® was performed. Among the 279 identified records, 19 were eligible for quality assessment and 10 for further meta-analysis. The completeness of reporting was high across papers, but over 50% were considered subject to potential risk of bias. Mean age at diagnosis was 31.9 years. None considered effects of EDCs multipollutant mixtures. The meta-analyses showed that maternal exposure to combined EDCs was associated with a higher risk of testicular cancer in male offspring (summary RRs: 2.16, (95% CI:1.78-2.62); 1.93 (95% CI:1.49-2.48); 2.78 (95% CI:2.27-3.41) for all, seminoma, non-seminoma respectively). Similarly, high maternal exposures to grouped organochlorines and organo-halogens were associated with higher risk of seminoma and non-seminoma in the offspring. Summary estimates related to postnatal adult male EDC exposures were inconsistent.Maternal but not postnatal adult male, EDC exposures were consistently associated with a higher risk of testicular cancer, particularly risk of non-seminomas. However, the quality of studies was mixed and considering the fields complexity, more prospective studies of prenatal EDC multipollutant mixture exposures and testicular cancer are needed.

U2 - 10.1210/clinem/dgab523

DO - 10.1210/clinem/dgab523

M3 - Journal article

C2 - 34270734

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

ER -

ID: 274832703