Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother-Child Study (NewGeneris)

Research output: Contribution to journalJournal articleResearchpeer-review

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Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood : A European Mother-Child Study (NewGeneris). / Pedersen, Marie; Mendez, Michelle A; Schoket, Bernadette; Godschalk, Roger W; Espinosa, Ana; Landström, Anette; Villanueva, Cristina M; Merlo, Domenico F; Fthenou, Eleni; Gracia-Lavedan, Esther; van Schooten, Frederik-J; Hoek, Gerard; Brunborg, Gunnar; Meltzer, Helle M; Alexander, Jan; Nielsen, Jeanette Kolstrup Søgaard; Sunyer, Jordi; Wright, John; Kovács, Katalin; de Hoogh, Kees; Gutzkow, Kristine B; Hardie, Laura J; Chatzi, Leda; Knudsen, Lisbeth E.; Anna, Lívia; Ketzel, Matthias; Haugen, Margaretha; Botsivali, Maria; Nieuwenhuijsen, Mark J; Cirach, Marta; Toledano, Mireille B; Smith, Rachel B; Fleming, Sarah; Agramunt, Silvia; Kyrtopoulos, Soterios A; Lukács, Viktória; Kleinjans, Jos C; Segerbäck, Dan; Kogevinas, Manolis.

In: Environmental Health Perspectives, Vol. 123, No. 4, 04.2015, p. 374-380.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pedersen, M, Mendez, MA, Schoket, B, Godschalk, RW, Espinosa, A, Landström, A, Villanueva, CM, Merlo, DF, Fthenou, E, Gracia-Lavedan, E, van Schooten, F-J, Hoek, G, Brunborg, G, Meltzer, HM, Alexander, J, Nielsen, JKS, Sunyer, J, Wright, J, Kovács, K, de Hoogh, K, Gutzkow, KB, Hardie, LJ, Chatzi, L, Knudsen, LE, Anna, L, Ketzel, M, Haugen, M, Botsivali, M, Nieuwenhuijsen, MJ, Cirach, M, Toledano, MB, Smith, RB, Fleming, S, Agramunt, S, Kyrtopoulos, SA, Lukács, V, Kleinjans, JC, Segerbäck, D & Kogevinas, M 2015, 'Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother-Child Study (NewGeneris)', Environmental Health Perspectives, vol. 123, no. 4, pp. 374-380. https://doi.org/10.1289/ehp.1408613

APA

Pedersen, M., Mendez, M. A., Schoket, B., Godschalk, R. W., Espinosa, A., Landström, A., ... Kogevinas, M. (2015). Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother-Child Study (NewGeneris). Environmental Health Perspectives, 123(4), 374-380. https://doi.org/10.1289/ehp.1408613

Vancouver

Pedersen M, Mendez MA, Schoket B, Godschalk RW, Espinosa A, Landström A et al. Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother-Child Study (NewGeneris). Environmental Health Perspectives. 2015 Apr;123(4):374-380. https://doi.org/10.1289/ehp.1408613

Author

Pedersen, Marie ; Mendez, Michelle A ; Schoket, Bernadette ; Godschalk, Roger W ; Espinosa, Ana ; Landström, Anette ; Villanueva, Cristina M ; Merlo, Domenico F ; Fthenou, Eleni ; Gracia-Lavedan, Esther ; van Schooten, Frederik-J ; Hoek, Gerard ; Brunborg, Gunnar ; Meltzer, Helle M ; Alexander, Jan ; Nielsen, Jeanette Kolstrup Søgaard ; Sunyer, Jordi ; Wright, John ; Kovács, Katalin ; de Hoogh, Kees ; Gutzkow, Kristine B ; Hardie, Laura J ; Chatzi, Leda ; Knudsen, Lisbeth E. ; Anna, Lívia ; Ketzel, Matthias ; Haugen, Margaretha ; Botsivali, Maria ; Nieuwenhuijsen, Mark J ; Cirach, Marta ; Toledano, Mireille B ; Smith, Rachel B ; Fleming, Sarah ; Agramunt, Silvia ; Kyrtopoulos, Soterios A ; Lukács, Viktória ; Kleinjans, Jos C ; Segerbäck, Dan ; Kogevinas, Manolis. / Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood : A European Mother-Child Study (NewGeneris). In: Environmental Health Perspectives. 2015 ; Vol. 123, No. 4. pp. 374-380.

Bibtex

@article{1de3292ab0e3453f84c5affdc8ec9338,
title = "Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother-Child Study (NewGeneris)",
abstract = "BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk.OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates.METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population.RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England.CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.",
author = "Marie Pedersen and Mendez, {Michelle A} and Bernadette Schoket and Godschalk, {Roger W} and Ana Espinosa and Anette Landstr{\"o}m and Villanueva, {Cristina M} and Merlo, {Domenico F} and Eleni Fthenou and Esther Gracia-Lavedan and {van Schooten}, Frederik-J and Gerard Hoek and Gunnar Brunborg and Meltzer, {Helle M} and Jan Alexander and Nielsen, {Jeanette Kolstrup S{\o}gaard} and Jordi Sunyer and John Wright and Katalin Kov{\'a}cs and {de Hoogh}, Kees and Gutzkow, {Kristine B} and Hardie, {Laura J} and Leda Chatzi and Knudsen, {Lisbeth E.} and L{\'i}via Anna and Matthias Ketzel and Margaretha Haugen and Maria Botsivali and Nieuwenhuijsen, {Mark J} and Marta Cirach and Toledano, {Mireille B} and Smith, {Rachel B} and Sarah Fleming and Silvia Agramunt and Kyrtopoulos, {Soterios A} and Vikt{\'o}ria Luk{\'a}cs and Kleinjans, {Jos C} and Dan Segerb{\"a}ck and Manolis Kogevinas",
year = "2015",
month = "4",
doi = "10.1289/ehp.1408613",
language = "English",
volume = "123",
pages = "374--380",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "National Institute of Environmental Health Sciences",
number = "4",

}

RIS

TY - JOUR

T1 - Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood

T2 - A European Mother-Child Study (NewGeneris)

AU - Pedersen, Marie

AU - Mendez, Michelle A

AU - Schoket, Bernadette

AU - Godschalk, Roger W

AU - Espinosa, Ana

AU - Landström, Anette

AU - Villanueva, Cristina M

AU - Merlo, Domenico F

AU - Fthenou, Eleni

AU - Gracia-Lavedan, Esther

AU - van Schooten, Frederik-J

AU - Hoek, Gerard

AU - Brunborg, Gunnar

AU - Meltzer, Helle M

AU - Alexander, Jan

AU - Nielsen, Jeanette Kolstrup Søgaard

AU - Sunyer, Jordi

AU - Wright, John

AU - Kovács, Katalin

AU - de Hoogh, Kees

AU - Gutzkow, Kristine B

AU - Hardie, Laura J

AU - Chatzi, Leda

AU - Knudsen, Lisbeth E.

AU - Anna, Lívia

AU - Ketzel, Matthias

AU - Haugen, Margaretha

AU - Botsivali, Maria

AU - Nieuwenhuijsen, Mark J

AU - Cirach, Marta

AU - Toledano, Mireille B

AU - Smith, Rachel B

AU - Fleming, Sarah

AU - Agramunt, Silvia

AU - Kyrtopoulos, Soterios A

AU - Lukács, Viktória

AU - Kleinjans, Jos C

AU - Segerbäck, Dan

AU - Kogevinas, Manolis

PY - 2015/4

Y1 - 2015/4

N2 - BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk.OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates.METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population.RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England.CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.

AB - BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk.OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates.METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population.RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England.CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.

U2 - 10.1289/ehp.1408613

DO - 10.1289/ehp.1408613

M3 - Journal article

C2 - 25626179

VL - 123

SP - 374

EP - 380

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 4

ER -

ID: 137756071