Extreme exercise and oxidative DNA modification

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Extreme exercise and oxidative DNA modification. / Poulsen, H E; Loft, S; Vistisen, K.

In: Journal of Sports Sciences, Vol. 14, No. 4, 08.1996, p. 343-6.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Poulsen, HE, Loft, S & Vistisen, K 1996, 'Extreme exercise and oxidative DNA modification', Journal of Sports Sciences, vol. 14, no. 4, pp. 343-6. https://doi.org/10.1080/02640419608727720

APA

Poulsen, H. E., Loft, S., & Vistisen, K. (1996). Extreme exercise and oxidative DNA modification. Journal of Sports Sciences, 14(4), 343-6. https://doi.org/10.1080/02640419608727720

Vancouver

Poulsen HE, Loft S, Vistisen K. Extreme exercise and oxidative DNA modification. Journal of Sports Sciences. 1996 Aug;14(4):343-6. https://doi.org/10.1080/02640419608727720

Author

Poulsen, H E ; Loft, S ; Vistisen, K. / Extreme exercise and oxidative DNA modification. In: Journal of Sports Sciences. 1996 ; Vol. 14, No. 4. pp. 343-6.

Bibtex

@article{acce5d5778194c12818f3e642370997f,
title = "Extreme exercise and oxidative DNA modification",
abstract = "Extreme exercise increases oxygen uptake with a potential for increased formation of reactive oxygen species. Damage to biomolecules may occur if such an increase exceeds the protective capacity of antioxidant defence mechanisms. Vigorous exercise amounting to approximately 10 h a day for 30 days increased the rate of oxidative DNA modification by 33{\%} (95{\%} confidence limits, 3-67{\%}; P < 0.02) in 20 men owing to the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine, an oxidatively modified deoxynucleoside originating from nuclear DNA repair, oxidation of the nucleotide pool from mitochondrial DNA and/or from cell turnover. Oxidative stress to DNA points to a risk for the development of cancer and premature ageing from extreme exercise.",
keywords = "Adult, Aging, Antioxidants, Creatinine, DNA, DNA Damage, DNA Repair, DNA, Mitochondrial, Deoxyguanosine, Exercise, Humans, Male, Neoplasms, Oxidation-Reduction, Oxidative Stress, Oxygen Consumption, Reactive Oxygen Species, Risk Factors",
author = "Poulsen, {H E} and S Loft and K Vistisen",
year = "1996",
month = "8",
doi = "10.1080/02640419608727720",
language = "English",
volume = "14",
pages = "343--6",
journal = "Journal of Sports Sciences",
issn = "0264-0414",
publisher = "Routledge",
number = "4",

}

RIS

TY - JOUR

T1 - Extreme exercise and oxidative DNA modification

AU - Poulsen, H E

AU - Loft, S

AU - Vistisen, K

PY - 1996/8

Y1 - 1996/8

N2 - Extreme exercise increases oxygen uptake with a potential for increased formation of reactive oxygen species. Damage to biomolecules may occur if such an increase exceeds the protective capacity of antioxidant defence mechanisms. Vigorous exercise amounting to approximately 10 h a day for 30 days increased the rate of oxidative DNA modification by 33% (95% confidence limits, 3-67%; P < 0.02) in 20 men owing to the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine, an oxidatively modified deoxynucleoside originating from nuclear DNA repair, oxidation of the nucleotide pool from mitochondrial DNA and/or from cell turnover. Oxidative stress to DNA points to a risk for the development of cancer and premature ageing from extreme exercise.

AB - Extreme exercise increases oxygen uptake with a potential for increased formation of reactive oxygen species. Damage to biomolecules may occur if such an increase exceeds the protective capacity of antioxidant defence mechanisms. Vigorous exercise amounting to approximately 10 h a day for 30 days increased the rate of oxidative DNA modification by 33% (95% confidence limits, 3-67%; P < 0.02) in 20 men owing to the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine, an oxidatively modified deoxynucleoside originating from nuclear DNA repair, oxidation of the nucleotide pool from mitochondrial DNA and/or from cell turnover. Oxidative stress to DNA points to a risk for the development of cancer and premature ageing from extreme exercise.

KW - Adult

KW - Aging

KW - Antioxidants

KW - Creatinine

KW - DNA

KW - DNA Damage

KW - DNA Repair

KW - DNA, Mitochondrial

KW - Deoxyguanosine

KW - Exercise

KW - Humans

KW - Male

KW - Neoplasms

KW - Oxidation-Reduction

KW - Oxidative Stress

KW - Oxygen Consumption

KW - Reactive Oxygen Species

KW - Risk Factors

U2 - 10.1080/02640419608727720

DO - 10.1080/02640419608727720

M3 - Journal article

C2 - 8887214

VL - 14

SP - 343

EP - 346

JO - Journal of Sports Sciences

JF - Journal of Sports Sciences

SN - 0264-0414

IS - 4

ER -

ID: 156510081