TY - JOUR

T1 - Fertility treatment and child intelligence, attention, and executive functions in 5-year-old singletons

T2 - a cohort study

AU - Bay, B

AU - Mortensen, E L

AU - Kesmodel, U S

N1 - © 2014 Royal College of Obstetricians and Gynaecologists.

PY - 2014/12

Y1 - 2014/12

N2 - OBJECTIVE: To assess the association of fertility treatment and subfertility with offspring intelligence, attention, and executive functions in 5-year-old singletons.DESIGN: Follow-up study.SETTING: Denmark 2003-2008.POPULATION: A cohort of 1782 children sampled from the Danish National Birth Cohort.METHODS: The children were tested with a neuropsychological battery at age five. In addition to tests of intelligence, attention and executive functions, the follow up included extensive information on important covariates. The analyses were conducted using multiple linear regression and adjusted for parental educational level, maternal intelligence, age, parity, body mass index, smoking in pregnancy, alcohol consumption in pregnancy and child gender, child age, and examiner.MAIN OUTCOME MEASURES: Wechsler Preschool and Primary Scale of Intelligence-Revised, the Test of Everyday Attention for Children at Five, and the Behavior Rating Inventory of Executive Functions scores.RESULTS: A consistent pattern of nonsignificantly lower scores were only observed for intelligence and executive functions in children born after fertility treatment or by subfertile parents when the results were unadjusted for maternal intelligence and parental educational level. When adjusted for these and other covariates, there were no significant mean differences in intelligence (mean difference -2.8, 95% CI -7.8, 2.2), overall attention (-0.1, 95% CI -0.6, 0.3), or parent-rated executive functions (-0.1, 95% CI -3.0, 2.9) between children born after spontaneous conception and children born to parents conceiving after fertility treatment. Similarly, there were no significant mean differences in intelligence (mean difference 0.6, 95% CI -2.2, 3.4), overall attention (0.1, 95% CI -0.2, 0.4), or parent-rated executive functions (1.0, 95% CI -1.8, 3.7) between children born after spontaneous conception and children born to subfertile parents waiting more than 12 months before conceiving naturally.CONCLUSIONS: This study suggests that parental subfertility and fertility treatment are unrelated to offspring intelligence, attention and executive functions.

AB - OBJECTIVE: To assess the association of fertility treatment and subfertility with offspring intelligence, attention, and executive functions in 5-year-old singletons.DESIGN: Follow-up study.SETTING: Denmark 2003-2008.POPULATION: A cohort of 1782 children sampled from the Danish National Birth Cohort.METHODS: The children were tested with a neuropsychological battery at age five. In addition to tests of intelligence, attention and executive functions, the follow up included extensive information on important covariates. The analyses were conducted using multiple linear regression and adjusted for parental educational level, maternal intelligence, age, parity, body mass index, smoking in pregnancy, alcohol consumption in pregnancy and child gender, child age, and examiner.MAIN OUTCOME MEASURES: Wechsler Preschool and Primary Scale of Intelligence-Revised, the Test of Everyday Attention for Children at Five, and the Behavior Rating Inventory of Executive Functions scores.RESULTS: A consistent pattern of nonsignificantly lower scores were only observed for intelligence and executive functions in children born after fertility treatment or by subfertile parents when the results were unadjusted for maternal intelligence and parental educational level. When adjusted for these and other covariates, there were no significant mean differences in intelligence (mean difference -2.8, 95% CI -7.8, 2.2), overall attention (-0.1, 95% CI -0.6, 0.3), or parent-rated executive functions (-0.1, 95% CI -3.0, 2.9) between children born after spontaneous conception and children born to parents conceiving after fertility treatment. Similarly, there were no significant mean differences in intelligence (mean difference 0.6, 95% CI -2.2, 3.4), overall attention (0.1, 95% CI -0.2, 0.4), or parent-rated executive functions (1.0, 95% CI -1.8, 3.7) between children born after spontaneous conception and children born to subfertile parents waiting more than 12 months before conceiving naturally.CONCLUSIONS: This study suggests that parental subfertility and fertility treatment are unrelated to offspring intelligence, attention and executive functions.

KW - Adult

KW - Alcohol Drinking

KW - Attention

KW - Body Mass Index

KW - Child Development

KW - Child, Preschool

KW - Cohort Studies

KW - Denmark

KW - Developmental Disabilities

KW - Educational Status

KW - Executive Function

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infertility

KW - Intelligence

KW - Linear Models

KW - Male

KW - Neuropsychological Tests

KW - Parents

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Reproductive Techniques, Assisted

KW - Smoking

KW - Time-to-Pregnancy

KW - Wechsler Scales

U2 - 10.1111/1471-0528.12907

DO - 10.1111/1471-0528.12907

M3 - Journal article

C2 - 24910085

VL - 121

SP - 1642

EP - 1651

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 0140-7686

IS - 13

ER -