Fetal programming of semen quality (Fepos) cohort – a dnbc male-offspring cohort

Research output: Contribution to journalJournal articlepeer-review

Standard

Fetal programming of semen quality (Fepos) cohort – a dnbc male-offspring cohort. / Hærvig, Katia Keglberg; Bonde, Jens Peter; Ramlau-Hansen, Cecilia Høst; Toft, Gunnar; Hougaard, Karin Sørig; Specht, Ina Olmer; Giwercman, Aleksander; Andersen, Anne Marie Nybo; Olsen, Jørn; Lindh, Christian; Høyer, Birgit Bjerre; Tøttenbo, Sandra Søgaard.

In: Clinical Epidemiology, Vol. 12, 2020, p. 757-770.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hærvig, KK, Bonde, JP, Ramlau-Hansen, CH, Toft, G, Hougaard, KS, Specht, IO, Giwercman, A, Andersen, AMN, Olsen, J, Lindh, C, Høyer, BB & Tøttenbo, SS 2020, 'Fetal programming of semen quality (Fepos) cohort – a dnbc male-offspring cohort', Clinical Epidemiology, vol. 12, pp. 757-770. https://doi.org/10.2147/CLEP.S242631

APA

Hærvig, K. K., Bonde, J. P., Ramlau-Hansen, C. H., Toft, G., Hougaard, K. S., Specht, I. O., Giwercman, A., Andersen, A. M. N., Olsen, J., Lindh, C., Høyer, B. B., & Tøttenbo, S. S. (2020). Fetal programming of semen quality (Fepos) cohort – a dnbc male-offspring cohort. Clinical Epidemiology, 12, 757-770. https://doi.org/10.2147/CLEP.S242631

Vancouver

Hærvig KK, Bonde JP, Ramlau-Hansen CH, Toft G, Hougaard KS, Specht IO et al. Fetal programming of semen quality (Fepos) cohort – a dnbc male-offspring cohort. Clinical Epidemiology. 2020;12:757-770. https://doi.org/10.2147/CLEP.S242631

Author

Hærvig, Katia Keglberg ; Bonde, Jens Peter ; Ramlau-Hansen, Cecilia Høst ; Toft, Gunnar ; Hougaard, Karin Sørig ; Specht, Ina Olmer ; Giwercman, Aleksander ; Andersen, Anne Marie Nybo ; Olsen, Jørn ; Lindh, Christian ; Høyer, Birgit Bjerre ; Tøttenbo, Sandra Søgaard. / Fetal programming of semen quality (Fepos) cohort – a dnbc male-offspring cohort. In: Clinical Epidemiology. 2020 ; Vol. 12. pp. 757-770.

Bibtex

@article{0f2dbfbbc952434dab853e2200ae6642,
title = "Fetal programming of semen quality (Fepos) cohort – a dnbc male-offspring cohort",
abstract = "Background: Prenatal exposures may contribute to male infertility in adult life, but large-scale epidemiological evidence is still lacking. The Fetal Programming of Semen quality (FEPOS) cohort was founded to provide means to examine if fetal exposures can interfere with fetal reproductive development and ultimately lead to reduced semen quality and reproductive hormone imbalances in young adult men. Methods: Young adult men at least 18 years and 9 months of age born to women in the Danish National Birth Cohort living in relative proximity to Copenhagen or Aarhus and for whom a maternal blood sample and two maternal interviews during pregnancy were available were invited to FEPOS. Recruitment began in March 2017 and ended in December 2019. The participants answered a comprehensive questionnaire and underwent a physical examination where they delivered a semen, urine, and hair sample, measured their own testicular volume, and had blood drawn. Results: In total 21,623 sons fulfilled eligibility criteria of whom 5697 were invited and 1058 participated making the response rate 19%. Semen characteristics did not differ between sons from the Copenhagen and Aarhus clinics. When comparing the FEPOS semen parameters to similar cohorts, the median across all semen characteristics was slightly lower for FEPOS participants, although with smaller variation. Conclusion: With its 1058 young adult men, the FEPOS cohort is the largest population-based male-offspring cohort worldwide specifically designed to investigate prenatal determinants of semen quality. Wide-ranging information on maternal health, lifestyle, socioeconomic status, occupation, and serum concentrations of potential reproductive toxicants during pregnancy combined with biological markers of fertility in their sons collected after puberty allow for in-depth investigations of the {\textquoteleft}fetal origins of adult disease hypothesis{\textquoteright}.",
keywords = "Fetal exposure, Male infertility, Maternal-fetal exchange, Prenatal exposure, Semen analysis, Semen quality",
author = "H{\ae}rvig, {Katia Keglberg} and Bonde, {Jens Peter} and Ramlau-Hansen, {Cecilia H{\o}st} and Gunnar Toft and Hougaard, {Karin S{\o}rig} and Specht, {Ina Olmer} and Aleksander Giwercman and Andersen, {Anne Marie Nybo} and J{\o}rn Olsen and Christian Lindh and H{\o}yer, {Birgit Bjerre} and T{\o}ttenbo, {Sandra S{\o}gaard}",
year = "2020",
doi = "10.2147/CLEP.S242631",
language = "English",
volume = "12",
pages = "757--770",
journal = "Clinical Epidemiology",
issn = "1179-1349",
publisher = "Dove Medical Press Ltd",

}

RIS

TY - JOUR

T1 - Fetal programming of semen quality (Fepos) cohort – a dnbc male-offspring cohort

AU - Hærvig, Katia Keglberg

AU - Bonde, Jens Peter

AU - Ramlau-Hansen, Cecilia Høst

AU - Toft, Gunnar

AU - Hougaard, Karin Sørig

AU - Specht, Ina Olmer

AU - Giwercman, Aleksander

AU - Andersen, Anne Marie Nybo

AU - Olsen, Jørn

AU - Lindh, Christian

AU - Høyer, Birgit Bjerre

AU - Tøttenbo, Sandra Søgaard

PY - 2020

Y1 - 2020

N2 - Background: Prenatal exposures may contribute to male infertility in adult life, but large-scale epidemiological evidence is still lacking. The Fetal Programming of Semen quality (FEPOS) cohort was founded to provide means to examine if fetal exposures can interfere with fetal reproductive development and ultimately lead to reduced semen quality and reproductive hormone imbalances in young adult men. Methods: Young adult men at least 18 years and 9 months of age born to women in the Danish National Birth Cohort living in relative proximity to Copenhagen or Aarhus and for whom a maternal blood sample and two maternal interviews during pregnancy were available were invited to FEPOS. Recruitment began in March 2017 and ended in December 2019. The participants answered a comprehensive questionnaire and underwent a physical examination where they delivered a semen, urine, and hair sample, measured their own testicular volume, and had blood drawn. Results: In total 21,623 sons fulfilled eligibility criteria of whom 5697 were invited and 1058 participated making the response rate 19%. Semen characteristics did not differ between sons from the Copenhagen and Aarhus clinics. When comparing the FEPOS semen parameters to similar cohorts, the median across all semen characteristics was slightly lower for FEPOS participants, although with smaller variation. Conclusion: With its 1058 young adult men, the FEPOS cohort is the largest population-based male-offspring cohort worldwide specifically designed to investigate prenatal determinants of semen quality. Wide-ranging information on maternal health, lifestyle, socioeconomic status, occupation, and serum concentrations of potential reproductive toxicants during pregnancy combined with biological markers of fertility in their sons collected after puberty allow for in-depth investigations of the ‘fetal origins of adult disease hypothesis’.

AB - Background: Prenatal exposures may contribute to male infertility in adult life, but large-scale epidemiological evidence is still lacking. The Fetal Programming of Semen quality (FEPOS) cohort was founded to provide means to examine if fetal exposures can interfere with fetal reproductive development and ultimately lead to reduced semen quality and reproductive hormone imbalances in young adult men. Methods: Young adult men at least 18 years and 9 months of age born to women in the Danish National Birth Cohort living in relative proximity to Copenhagen or Aarhus and for whom a maternal blood sample and two maternal interviews during pregnancy were available were invited to FEPOS. Recruitment began in March 2017 and ended in December 2019. The participants answered a comprehensive questionnaire and underwent a physical examination where they delivered a semen, urine, and hair sample, measured their own testicular volume, and had blood drawn. Results: In total 21,623 sons fulfilled eligibility criteria of whom 5697 were invited and 1058 participated making the response rate 19%. Semen characteristics did not differ between sons from the Copenhagen and Aarhus clinics. When comparing the FEPOS semen parameters to similar cohorts, the median across all semen characteristics was slightly lower for FEPOS participants, although with smaller variation. Conclusion: With its 1058 young adult men, the FEPOS cohort is the largest population-based male-offspring cohort worldwide specifically designed to investigate prenatal determinants of semen quality. Wide-ranging information on maternal health, lifestyle, socioeconomic status, occupation, and serum concentrations of potential reproductive toxicants during pregnancy combined with biological markers of fertility in their sons collected after puberty allow for in-depth investigations of the ‘fetal origins of adult disease hypothesis’.

KW - Fetal exposure

KW - Male infertility

KW - Maternal-fetal exchange

KW - Prenatal exposure

KW - Semen analysis

KW - Semen quality

U2 - 10.2147/CLEP.S242631

DO - 10.2147/CLEP.S242631

M3 - Journal article

C2 - 32765110

AN - SCOPUS:85088493641

VL - 12

SP - 757

EP - 770

JO - Clinical Epidemiology

JF - Clinical Epidemiology

SN - 1179-1349

ER -

ID: 245429769