Flavonoid intake and its association with atrial fibrillation
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Flavonoid intake and its association with atrial fibrillation. / Bondonno, Nicola P.; Murray, Kevin; Bondonno, Catherine P.; Lewis, Joshua R.; Croft, Kevin D.; Kyrø, Cecilie; Gislason, Gunnar; Tjonneland, Anne; Scalbert, Augustin; Cassidy, Aedin; Piccini, Jonathan P.; Overvad, Kim; Hodgson, Jonathan M.; Dalgaard, Frederik.
In: Clinical Nutrition, Vol. 39, No. 12, 2020, p. 3821-3828.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Flavonoid intake and its association with atrial fibrillation
AU - Bondonno, Nicola P.
AU - Murray, Kevin
AU - Bondonno, Catherine P.
AU - Lewis, Joshua R.
AU - Croft, Kevin D.
AU - Kyrø, Cecilie
AU - Gislason, Gunnar
AU - Tjonneland, Anne
AU - Scalbert, Augustin
AU - Cassidy, Aedin
AU - Piccini, Jonathan P.
AU - Overvad, Kim
AU - Hodgson, Jonathan M.
AU - Dalgaard, Frederik
PY - 2020
Y1 - 2020
N2 - Background & aims: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF.Methods: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models.Results: During a median [IQR] follow-up of 21 [18-22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [Conclusion: Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
AB - Background & aims: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF.Methods: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models.Results: During a median [IQR] follow-up of 21 [18-22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [Conclusion: Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
KW - Atrial fibrillation
KW - Flavonoids
KW - Prospective cohort study
KW - Primary prevention
KW - Nutrition
KW - Cardiovascular disease
KW - FIBRILLATION
KW - DIET
KW - RISK
KW - CANCER
U2 - 10.1016/j.clnu.2020.04.025
DO - 10.1016/j.clnu.2020.04.025
M3 - Journal article
C2 - 32386860
VL - 39
SP - 3821
EP - 3828
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 12
ER -
ID: 254770614