Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. / Bondonno, Nicola P.; Dalgaard, Frederik; Kyrø, Cecilie; Murray, Kevin; Bondonno, Catherine P.; Lewis, Joshua R.; Croft, Kevin D.; Gislason, Gunnar; Scalbert, Augustin; Cassidy, Aedin; Tjønneland, Anne; Overvad, Kim; Hodgson, Jonathan M.

In: Nature Communications, Vol. 10, No. 1, 3651, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bondonno, NP, Dalgaard, F, Kyrø, C, Murray, K, Bondonno, CP, Lewis, JR, Croft, KD, Gislason, G, Scalbert, A, Cassidy, A, Tjønneland, A, Overvad, K & Hodgson, JM 2019, 'Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort', Nature Communications, vol. 10, no. 1, 3651. https://doi.org/10.1038/s41467-019-11622-x

APA

Bondonno, N. P., Dalgaard, F., Kyrø, C., Murray, K., Bondonno, C. P., Lewis, J. R., Croft, K. D., Gislason, G., Scalbert, A., Cassidy, A., Tjønneland, A., Overvad, K., & Hodgson, J. M. (2019). Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. Nature Communications, 10(1), [3651]. https://doi.org/10.1038/s41467-019-11622-x

Vancouver

Bondonno NP, Dalgaard F, Kyrø C, Murray K, Bondonno CP, Lewis JR et al. Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. Nature Communications. 2019;10(1). 3651. https://doi.org/10.1038/s41467-019-11622-x

Author

Bondonno, Nicola P. ; Dalgaard, Frederik ; Kyrø, Cecilie ; Murray, Kevin ; Bondonno, Catherine P. ; Lewis, Joshua R. ; Croft, Kevin D. ; Gislason, Gunnar ; Scalbert, Augustin ; Cassidy, Aedin ; Tjønneland, Anne ; Overvad, Kim ; Hodgson, Jonathan M. / Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort. In: Nature Communications. 2019 ; Vol. 10, No. 1.

Bibtex

@article{1156160754754a44a3e4e477d865688e,
title = "Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort",
abstract = "Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits. However, evidence from observational studies is incomplete; studies on cancer mortality are scarce and moderating effects of lifestyle risk factors for early mortality are unknown. In this prospective cohort study including 56,048 participants of the Danish Diet, Cancer, and Health cohort crosslinked with Danish nationwide registries and followed for 23 years, there are 14,083 deaths. A moderate habitual intake of flavonoids is inversely associated with all-cause, cardiovascular- and cancer-related mortality. This strong association plateaus at intakes of approximately 500 mg/day. Furthermore, the inverse associations between total flavonoid intake and mortality outcomes are stronger and more linear in smokers than in non-smokers, as well as in heavy (>20 g/d) vs. low-moderate (<20 g/d) alcohol consumers. These findings highlight the potential to reduce mortality through recommendations to increase intakes of flavonoid-rich foods, particularly in smokers and high alcohol consumers.",
author = "Bondonno, {Nicola P.} and Frederik Dalgaard and Cecilie Kyr{\o} and Kevin Murray and Bondonno, {Catherine P.} and Lewis, {Joshua R.} and Croft, {Kevin D.} and Gunnar Gislason and Augustin Scalbert and Aedin Cassidy and Anne Tj{\o}nneland and Kim Overvad and Hodgson, {Jonathan M.}",
year = "2019",
doi = "10.1038/s41467-019-11622-x",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort

AU - Bondonno, Nicola P.

AU - Dalgaard, Frederik

AU - Kyrø, Cecilie

AU - Murray, Kevin

AU - Bondonno, Catherine P.

AU - Lewis, Joshua R.

AU - Croft, Kevin D.

AU - Gislason, Gunnar

AU - Scalbert, Augustin

AU - Cassidy, Aedin

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Hodgson, Jonathan M.

PY - 2019

Y1 - 2019

N2 - Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits. However, evidence from observational studies is incomplete; studies on cancer mortality are scarce and moderating effects of lifestyle risk factors for early mortality are unknown. In this prospective cohort study including 56,048 participants of the Danish Diet, Cancer, and Health cohort crosslinked with Danish nationwide registries and followed for 23 years, there are 14,083 deaths. A moderate habitual intake of flavonoids is inversely associated with all-cause, cardiovascular- and cancer-related mortality. This strong association plateaus at intakes of approximately 500 mg/day. Furthermore, the inverse associations between total flavonoid intake and mortality outcomes are stronger and more linear in smokers than in non-smokers, as well as in heavy (>20 g/d) vs. low-moderate (<20 g/d) alcohol consumers. These findings highlight the potential to reduce mortality through recommendations to increase intakes of flavonoid-rich foods, particularly in smokers and high alcohol consumers.

AB - Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits. However, evidence from observational studies is incomplete; studies on cancer mortality are scarce and moderating effects of lifestyle risk factors for early mortality are unknown. In this prospective cohort study including 56,048 participants of the Danish Diet, Cancer, and Health cohort crosslinked with Danish nationwide registries and followed for 23 years, there are 14,083 deaths. A moderate habitual intake of flavonoids is inversely associated with all-cause, cardiovascular- and cancer-related mortality. This strong association plateaus at intakes of approximately 500 mg/day. Furthermore, the inverse associations between total flavonoid intake and mortality outcomes are stronger and more linear in smokers than in non-smokers, as well as in heavy (>20 g/d) vs. low-moderate (<20 g/d) alcohol consumers. These findings highlight the potential to reduce mortality through recommendations to increase intakes of flavonoid-rich foods, particularly in smokers and high alcohol consumers.

U2 - 10.1038/s41467-019-11622-x

DO - 10.1038/s41467-019-11622-x

M3 - Journal article

C2 - 31409784

AN - SCOPUS:85070811356

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 3651

ER -

ID: 240631865