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Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. / Cerhan, James R.; Berndt, Sonja I.; Vijai, Joseph; Ghesquières, Hervé; McKay, James; Wang, Sophia S.; Wang, Zhaoming; Yeager, Meredith; Conde, Lucia; De Bakker, Paul I.W.; Nieters, Alexandra; Cox, David; Burdett, Laurie; Monnereau, Alain; Flowers, Christopher R.; De Roos, Anneclaire J.; Brooks-Wilson, Angela R.; Lan, Qing; Severi, Gianluca; Melbye, Mads; Gu, Jian; Jackson, Rebecca D.; Kane, Eleanor; Teras, Lauren R.; Purdue, Mark P.; Vajdic, Claire M.; Spinelli, John J.; Giles, Graham G.; Albanes, Demetrius; Kelly, Rachel S.; Zucca, Mariagrazia; Bertrand, Kimberly A.; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Hutchinson, Amy; Zhi, Degui; Habermann, Thomas M.; Link, Brian K.; Novak, Anne J.; Dogan, Ahmet; Asmann, Yan W.; Liebow, Mark; Thompson, Carrie A.; Ansell, Stephen M.; Witzig, Thomas E.; Weiner, George J.; Veron, Amelie S.; Zelenika, Diana; Hjalgrim, Henrik; Tjonneland, Anne.
In:
Nature Genetics, Vol. 46, No. 11, 05.11.2014, p. 1233-1238.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Cerhan, JR, Berndt, SI, Vijai, J, Ghesquières, H, McKay, J, Wang, SS, Wang, Z, Yeager, M, Conde, L, De Bakker, PIW, Nieters, A, Cox, D, Burdett, L, Monnereau, A, Flowers, CR, De Roos, AJ, Brooks-Wilson, AR, Lan, Q, Severi, G, Melbye, M, Gu, J, Jackson, RD, Kane, E, Teras, LR, Purdue, MP, Vajdic, CM, Spinelli, JJ, Giles, GG, Albanes, D, Kelly, RS, Zucca, M, Bertrand, KA, Zeleniuch-Jacquotte, A, Lawrence, C, Hutchinson, A, Zhi, D, Habermann, TM, Link, BK, Novak, AJ, Dogan, A, Asmann, YW, Liebow, M, Thompson, CA, Ansell, SM, Witzig, TE, Weiner, GJ, Veron, AS, Zelenika, D, Hjalgrim, H
& Tjonneland, A 2014, '
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma',
Nature Genetics, vol. 46, no. 11, pp. 1233-1238.
https://doi.org/10.1038/ng.3105APA
Cerhan, J. R., Berndt, S. I., Vijai, J., Ghesquières, H., McKay, J., Wang, S. S., Wang, Z., Yeager, M., Conde, L., De Bakker, P. I. W., Nieters, A., Cox, D., Burdett, L., Monnereau, A., Flowers, C. R., De Roos, A. J., Brooks-Wilson, A. R., Lan, Q., Severi, G.
, ... Tjonneland, A. (2014).
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
Nature Genetics,
46(11), 1233-1238.
https://doi.org/10.1038/ng.3105Vancouver
Cerhan JR, Berndt SI, Vijai J, Ghesquières H, McKay J, Wang SS et al.
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
Nature Genetics. 2014 Nov 5;46(11):1233-1238.
https://doi.org/10.1038/ng.3105Author
Cerhan, James R. ; Berndt, Sonja I. ; Vijai, Joseph ; Ghesquières, Hervé ; McKay, James ; Wang, Sophia S. ; Wang, Zhaoming ; Yeager, Meredith ; Conde, Lucia ; De Bakker, Paul I.W. ; Nieters, Alexandra ; Cox, David ; Burdett, Laurie ; Monnereau, Alain ; Flowers, Christopher R. ; De Roos, Anneclaire J. ; Brooks-Wilson, Angela R. ; Lan, Qing ; Severi, Gianluca ; Melbye, Mads ; Gu, Jian ; Jackson, Rebecca D. ; Kane, Eleanor ; Teras, Lauren R. ; Purdue, Mark P. ; Vajdic, Claire M. ; Spinelli, John J. ; Giles, Graham G. ; Albanes, Demetrius ; Kelly, Rachel S. ; Zucca, Mariagrazia ; Bertrand, Kimberly A. ; Zeleniuch-Jacquotte, Anne ; Lawrence, Charles ; Hutchinson, Amy ; Zhi, Degui ; Habermann, Thomas M. ; Link, Brian K. ; Novak, Anne J. ; Dogan, Ahmet ; Asmann, Yan W. ; Liebow, Mark ; Thompson, Carrie A. ; Ansell, Stephen M. ; Witzig, Thomas E. ; Weiner, George J. ; Veron, Amelie S. ; Zelenika, Diana ; Hjalgrim, Henrik ; Tjonneland, Anne. / Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. In: Nature Genetics. 2014 ; Vol. 46, No. 11. pp. 1233-1238.
Bibtex
@article{149d9d732b2e412ebeca62a43ef3c740,
title = "Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma",
abstract = "Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.",
author = "Cerhan, {James R.} and Berndt, {Sonja I.} and Joseph Vijai and Herv{\'e} Ghesqui{\`e}res and James McKay and Wang, {Sophia S.} and Zhaoming Wang and Meredith Yeager and Lucia Conde and {De Bakker}, {Paul I.W.} and Alexandra Nieters and David Cox and Laurie Burdett and Alain Monnereau and Flowers, {Christopher R.} and {De Roos}, {Anneclaire J.} and Brooks-Wilson, {Angela R.} and Qing Lan and Gianluca Severi and Mads Melbye and Jian Gu and Jackson, {Rebecca D.} and Eleanor Kane and Teras, {Lauren R.} and Purdue, {Mark P.} and Vajdic, {Claire M.} and Spinelli, {John J.} and Giles, {Graham G.} and Demetrius Albanes and Kelly, {Rachel S.} and Mariagrazia Zucca and Bertrand, {Kimberly A.} and Anne Zeleniuch-Jacquotte and Charles Lawrence and Amy Hutchinson and Degui Zhi and Habermann, {Thomas M.} and Link, {Brian K.} and Novak, {Anne J.} and Ahmet Dogan and Asmann, {Yan W.} and Mark Liebow and Thompson, {Carrie A.} and Ansell, {Stephen M.} and Witzig, {Thomas E.} and Weiner, {George J.} and Veron, {Amelie S.} and Diana Zelenika and Henrik Hjalgrim and Anne Tjonneland",
year = "2014",
month = nov,
day = "5",
doi = "10.1038/ng.3105",
language = "English",
volume = "46",
pages = "1233--1238",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "11",
}
RIS
TY - JOUR
T1 - Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
AU - Cerhan, James R.
AU - Berndt, Sonja I.
AU - Vijai, Joseph
AU - Ghesquières, Hervé
AU - McKay, James
AU - Wang, Sophia S.
AU - Wang, Zhaoming
AU - Yeager, Meredith
AU - Conde, Lucia
AU - De Bakker, Paul I.W.
AU - Nieters, Alexandra
AU - Cox, David
AU - Burdett, Laurie
AU - Monnereau, Alain
AU - Flowers, Christopher R.
AU - De Roos, Anneclaire J.
AU - Brooks-Wilson, Angela R.
AU - Lan, Qing
AU - Severi, Gianluca
AU - Melbye, Mads
AU - Gu, Jian
AU - Jackson, Rebecca D.
AU - Kane, Eleanor
AU - Teras, Lauren R.
AU - Purdue, Mark P.
AU - Vajdic, Claire M.
AU - Spinelli, John J.
AU - Giles, Graham G.
AU - Albanes, Demetrius
AU - Kelly, Rachel S.
AU - Zucca, Mariagrazia
AU - Bertrand, Kimberly A.
AU - Zeleniuch-Jacquotte, Anne
AU - Lawrence, Charles
AU - Hutchinson, Amy
AU - Zhi, Degui
AU - Habermann, Thomas M.
AU - Link, Brian K.
AU - Novak, Anne J.
AU - Dogan, Ahmet
AU - Asmann, Yan W.
AU - Liebow, Mark
AU - Thompson, Carrie A.
AU - Ansell, Stephen M.
AU - Witzig, Thomas E.
AU - Weiner, George J.
AU - Veron, Amelie S.
AU - Zelenika, Diana
AU - Hjalgrim, Henrik
AU - Tjonneland, Anne
PY - 2014/11/5
Y1 - 2014/11/5
N2 - Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
AB - Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
U2 - 10.1038/ng.3105
DO - 10.1038/ng.3105
M3 - Journal article
C2 - 25261932
AN - SCOPUS:84908886283
VL - 46
SP - 1233
EP - 1238
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -
