Genomic damage in children accidentally exposed to ionizing radiation: a review of the literature

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genomic damage in children accidentally exposed to ionizing radiation : a review of the literature. / Fucic, A; Brunborg, G; Lasan, R; Jezek, D; Knudsen, Lisbeth E.; Merlo, D F.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 658, No. 1-2, 25.12.2007, p. 111-23.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fucic, A, Brunborg, G, Lasan, R, Jezek, D, Knudsen, LE & Merlo, DF 2007, 'Genomic damage in children accidentally exposed to ionizing radiation: a review of the literature', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 658, no. 1-2, pp. 111-23. https://doi.org/10.1016/j.mrrev.2007.11.003

APA

Fucic, A., Brunborg, G., Lasan, R., Jezek, D., Knudsen, L. E., & Merlo, D. F. (2007). Genomic damage in children accidentally exposed to ionizing radiation: a review of the literature. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 658(1-2), 111-23. https://doi.org/10.1016/j.mrrev.2007.11.003

Vancouver

Fucic A, Brunborg G, Lasan R, Jezek D, Knudsen LE, Merlo DF. Genomic damage in children accidentally exposed to ionizing radiation: a review of the literature. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2007 Dec 25;658(1-2):111-23. https://doi.org/10.1016/j.mrrev.2007.11.003

Author

Fucic, A ; Brunborg, G ; Lasan, R ; Jezek, D ; Knudsen, Lisbeth E. ; Merlo, D F. / Genomic damage in children accidentally exposed to ionizing radiation : a review of the literature. In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2007 ; Vol. 658, No. 1-2. pp. 111-23.

Bibtex

@article{338f533630804e54ad893c1ef55f5a5f,
title = "Genomic damage in children accidentally exposed to ionizing radiation: a review of the literature",
abstract = "During the last decade, our knowledge of the mechanisms by which children respond to exposures to physical and chemical agents present in the environment, has significantly increased. Results of recent projects and programmes focused on children's health underline a specific vulnerability of children to environmental genotoxicants. Environmental research on children predominantly investigates the health effects of air pollution while effects from radiation exposure deserve more attention. The main sources of knowledge on genome damage of children exposed to radiation are studies performed after the Chernobyl nuclear plant accident in 1986. The present review presents and discusses data collected from papers analyzing genome damage in children environmentally exposed to ionizing radiation. Overall, the evidence from the studies conducted following the Chernobyl accident, nuclear tests, environmental radiation pollution and indoor accidental contamination reveals consistently increased chromosome aberration and micronuclei frequency in exposed than in referent children. Future research in this area should be focused on studies providing information on: (a) effects on children caused by low doses of radiation; (b) effects on children from combined exposure to low doses of radiation and chemical agents from food, water and air; and (c) specific effects from exposure during early childhood (radioisotopes from water, radon in homes). Special consideration should also be given to a possible impact of a radiochemical environment to the development of an adaptive response for genomic damage. Interactive databases should be developed to provide integration of cytogenetic data, childhood cancer registry data and information on environmental contamination. The overall aim is to introduce timely and efficient preventive measures, by means of a better knowledge of the early and delayed health effects in children resulting from radiation exposure.",
keywords = "Chernobyl Nuclear Accident, Child, Chromosome Aberrations, DNA Damage, Dose-Response Relationship, Radiation, Environmental Exposure, Humans, Radiation, Ionizing, Radioactive Hazard Release",
author = "A Fucic and G Brunborg and R Lasan and D Jezek and Knudsen, {Lisbeth E.} and Merlo, {D F}",
year = "2007",
month = dec,
day = "25",
doi = "10.1016/j.mrrev.2007.11.003",
language = "English",
volume = "658",
pages = "111--23",
journal = "Mutation Research Letters",
issn = "0027-5107",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Genomic damage in children accidentally exposed to ionizing radiation

T2 - a review of the literature

AU - Fucic, A

AU - Brunborg, G

AU - Lasan, R

AU - Jezek, D

AU - Knudsen, Lisbeth E.

AU - Merlo, D F

PY - 2007/12/25

Y1 - 2007/12/25

N2 - During the last decade, our knowledge of the mechanisms by which children respond to exposures to physical and chemical agents present in the environment, has significantly increased. Results of recent projects and programmes focused on children's health underline a specific vulnerability of children to environmental genotoxicants. Environmental research on children predominantly investigates the health effects of air pollution while effects from radiation exposure deserve more attention. The main sources of knowledge on genome damage of children exposed to radiation are studies performed after the Chernobyl nuclear plant accident in 1986. The present review presents and discusses data collected from papers analyzing genome damage in children environmentally exposed to ionizing radiation. Overall, the evidence from the studies conducted following the Chernobyl accident, nuclear tests, environmental radiation pollution and indoor accidental contamination reveals consistently increased chromosome aberration and micronuclei frequency in exposed than in referent children. Future research in this area should be focused on studies providing information on: (a) effects on children caused by low doses of radiation; (b) effects on children from combined exposure to low doses of radiation and chemical agents from food, water and air; and (c) specific effects from exposure during early childhood (radioisotopes from water, radon in homes). Special consideration should also be given to a possible impact of a radiochemical environment to the development of an adaptive response for genomic damage. Interactive databases should be developed to provide integration of cytogenetic data, childhood cancer registry data and information on environmental contamination. The overall aim is to introduce timely and efficient preventive measures, by means of a better knowledge of the early and delayed health effects in children resulting from radiation exposure.

AB - During the last decade, our knowledge of the mechanisms by which children respond to exposures to physical and chemical agents present in the environment, has significantly increased. Results of recent projects and programmes focused on children's health underline a specific vulnerability of children to environmental genotoxicants. Environmental research on children predominantly investigates the health effects of air pollution while effects from radiation exposure deserve more attention. The main sources of knowledge on genome damage of children exposed to radiation are studies performed after the Chernobyl nuclear plant accident in 1986. The present review presents and discusses data collected from papers analyzing genome damage in children environmentally exposed to ionizing radiation. Overall, the evidence from the studies conducted following the Chernobyl accident, nuclear tests, environmental radiation pollution and indoor accidental contamination reveals consistently increased chromosome aberration and micronuclei frequency in exposed than in referent children. Future research in this area should be focused on studies providing information on: (a) effects on children caused by low doses of radiation; (b) effects on children from combined exposure to low doses of radiation and chemical agents from food, water and air; and (c) specific effects from exposure during early childhood (radioisotopes from water, radon in homes). Special consideration should also be given to a possible impact of a radiochemical environment to the development of an adaptive response for genomic damage. Interactive databases should be developed to provide integration of cytogenetic data, childhood cancer registry data and information on environmental contamination. The overall aim is to introduce timely and efficient preventive measures, by means of a better knowledge of the early and delayed health effects in children resulting from radiation exposure.

KW - Chernobyl Nuclear Accident

KW - Child

KW - Chromosome Aberrations

KW - DNA Damage

KW - Dose-Response Relationship, Radiation

KW - Environmental Exposure

KW - Humans

KW - Radiation, Ionizing

KW - Radioactive Hazard Release

U2 - 10.1016/j.mrrev.2007.11.003

DO - 10.1016/j.mrrev.2007.11.003

M3 - Journal article

C2 - 18155954

VL - 658

SP - 111

EP - 123

JO - Mutation Research Letters

JF - Mutation Research Letters

SN - 0027-5107

IS - 1-2

ER -

ID: 137758336