High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome

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Lise Aksglaede, Jørgen H Petersen, Katharina M Main, Niels E Skakkebaek, Anders Juul

Klinefelter's syndrome (KS) is associated with hypergonadotrophic hypogonadism in adulthood. However, limited information exists about the age at which hypogonadism occurs. The hypothalamic-pituitary-gonadal (HPG) axis is transiently activated during the first months of life, offering the opportunity to study testicular function by spontaneous, basal hormone levels. The aim of this study was to evaluate the HPG axis in KS infants.
Original languageEnglish
JournalEuropean Journal of Endocrinology
Volume157
Issue number3
Pages (from-to)345-50
Number of pages6
ISSN0804-4643
DOIs
Publication statusPublished - 2007

ID: 4031975