In utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder

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Nicole B Gidaya, Brian K Lee, Igor Burstyn, Michael Yudell, Erik L Mortensen, Craig J Newschaffer

We investigated whether there is an association between increased risk for autism spectrum disorders (ASD) and selective serotonin reuptake inhibitors (SSRIs) used during pregnancy. This study used Denmark's health and population registers to obtain information regarding prescription drugs, ASD diagnosis, and health and socioeconomic status. There were 1.5 % of cases and 0.7 % of controls exposed to SSRIs during the pregnancy period, and higher effect estimates observed with longer use. We found evidence that in utero exposure to SSRIs increases a child's risk associated with ASD. These results, while adding to the limited knowledge on prenatal pharmacological exposures as potential ASD risk factors, need to be balanced against the benefits of indicated medication use by pregnant mothers.

Original languageEnglish
JournalJournal of Autism and Developmental Disorders
Volume44
Issue number10
Pages (from-to)2558-67
Number of pages10
ISSN0162-3257
DOIs
Publication statusPublished - Oct 2014

ID: 123992872