Independent clinical significance of HIV antigen determination and CD4 counts in anti-HIV positive patients
Research output: Contribution to journal › Journal article › Research › peer-review
HIV antigenemia was found in 52/243 HIV antibody positive individuals attending 2 AIDS-screening clinics, giving a prevalence of 13, 25 and 76% in CDC groups II, III and IV, respectively. No correlation was found to decreased CD4 lymphocyte values in the individual groups. HIV antigen therefore identified a separate subpopulation. For 138 asymptomatic patients followed prospectively both laboratory parameters predicted HIV-related events, the relative risk factor being 4 for low CD4 value and 6 for presence of HIV antigen. Individuals presenting with HIV antigen and decreased CD4 count all developed disease within 18 months, the relative risk factor being 24. Thus the 2 markers, when measured together, effectively separated asymptomatic HIV-infected patients into 1 of 3 risk categories.
Original language | English |
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Journal | Scandinavian Journal of Infectious Diseases |
Volume | 21 |
Issue number | 2 |
Pages (from-to) | 149-53 |
Number of pages | 5 |
ISSN | 0036-5548 |
Publication status | Published - 1 Jan 1989 |
- Antigens, Differentiation, T-Lymphocyte, HIV Antibodies, HIV Antigens, HIV Seropositivity, Humans, Leukocyte Count, Lymphocytes, Predictive Value of Tests, Prognosis, Risk Factors
Research areas
ID: 33891257