Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylaminofluorene and dimethylsulfate in vitro

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylaminofluorene and dimethylsulfate in vitro. / Knudsen, Lisbeth E.; Ryder, L P; Wassermann, K.

In: Carcinogenesis, Vol. 13, No. 7, 07.1992, p. 1285-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Knudsen, LE, Ryder, LP & Wassermann, K 1992, 'Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylaminofluorene and dimethylsulfate in vitro', Carcinogenesis, vol. 13, no. 7, pp. 1285-7.

APA

Knudsen, L. E., Ryder, L. P., & Wassermann, K. (1992). Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylaminofluorene and dimethylsulfate in vitro. Carcinogenesis, 13(7), 1285-7.

Vancouver

Knudsen LE, Ryder LP, Wassermann K. Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylaminofluorene and dimethylsulfate in vitro. Carcinogenesis. 1992 Jul;13(7):1285-7.

Author

Knudsen, Lisbeth E. ; Ryder, L P ; Wassermann, K. / Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylaminofluorene and dimethylsulfate in vitro. In: Carcinogenesis. 1992 ; Vol. 13, No. 7. pp. 1285-7.

Bibtex

@article{e4994a8a0a274a4692513dc2d45542eb,
title = "Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylaminofluorene and dimethylsulfate in vitro",
abstract = "We have explored the induction of DNA repair synthesis in monocyte/B- and T-lymphocyte enriched cell fractions from 12 different human mononuclear blood cell populations. Unscheduled DNA synthesis was measured in monocyte/B- and T-cells after exposure to the DNA-damaging agents dimethylsulfate (DMS) and N-acetoxy-N-acetylaminofluorene in vitro. Also, the binding of DMS to DNA was measured. An increased DNA repair synthesis was measured in monocyte/B-lymphocytes after induction of the two different types of DNA lesions, whereas no induction of unscheduled DNA synthesis was observed in T-lymphocytes. A significantly higher DMS-DNA binding was also observed in monocyte/B-lymphocytes when compared with T-lymphocytes. Specific characterization of mononuclear blood cell populations used in biomonitoring of DNA adducts and repair is recommended.",
keywords = "Acetoxyacetylaminofluorene, B-Lymphocytes, Cells, Cultured, DNA Repair, DNA Replication, Humans, Monocytes, Sulfuric Acid Esters, T-Lymphocytes",
author = "Knudsen, {Lisbeth E.} and Ryder, {L P} and K Wassermann",
year = "1992",
month = jul,
language = "English",
volume = "13",
pages = "1285--7",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylaminofluorene and dimethylsulfate in vitro

AU - Knudsen, Lisbeth E.

AU - Ryder, L P

AU - Wassermann, K

PY - 1992/7

Y1 - 1992/7

N2 - We have explored the induction of DNA repair synthesis in monocyte/B- and T-lymphocyte enriched cell fractions from 12 different human mononuclear blood cell populations. Unscheduled DNA synthesis was measured in monocyte/B- and T-cells after exposure to the DNA-damaging agents dimethylsulfate (DMS) and N-acetoxy-N-acetylaminofluorene in vitro. Also, the binding of DMS to DNA was measured. An increased DNA repair synthesis was measured in monocyte/B-lymphocytes after induction of the two different types of DNA lesions, whereas no induction of unscheduled DNA synthesis was observed in T-lymphocytes. A significantly higher DMS-DNA binding was also observed in monocyte/B-lymphocytes when compared with T-lymphocytes. Specific characterization of mononuclear blood cell populations used in biomonitoring of DNA adducts and repair is recommended.

AB - We have explored the induction of DNA repair synthesis in monocyte/B- and T-lymphocyte enriched cell fractions from 12 different human mononuclear blood cell populations. Unscheduled DNA synthesis was measured in monocyte/B- and T-cells after exposure to the DNA-damaging agents dimethylsulfate (DMS) and N-acetoxy-N-acetylaminofluorene in vitro. Also, the binding of DMS to DNA was measured. An increased DNA repair synthesis was measured in monocyte/B-lymphocytes after induction of the two different types of DNA lesions, whereas no induction of unscheduled DNA synthesis was observed in T-lymphocytes. A significantly higher DMS-DNA binding was also observed in monocyte/B-lymphocytes when compared with T-lymphocytes. Specific characterization of mononuclear blood cell populations used in biomonitoring of DNA adducts and repair is recommended.

KW - Acetoxyacetylaminofluorene

KW - B-Lymphocytes

KW - Cells, Cultured

KW - DNA Repair

KW - DNA Replication

KW - Humans

KW - Monocytes

KW - Sulfuric Acid Esters

KW - T-Lymphocytes

M3 - Journal article

C2 - 1638700

VL - 13

SP - 1285

EP - 1287

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 7

ER -

ID: 137758792