Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity

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Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity. / Jensen, Annie; Løhr, Mille; Eriksen, Louise; Grønbæk, Morten; Dorry, Elad; Loft, Steffen; Møller, Peter.

In: Free Radical Biology & Medicine, Vol. 52, No. 1, 2012, p. 118-25.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jensen, A, Løhr, M, Eriksen, L, Grønbæk, M, Dorry, E, Loft, S & Møller, P 2012, 'Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity', Free Radical Biology & Medicine, vol. 52, no. 1, pp. 118-25. https://doi.org/10.1016/j.freeradbiomed.2011.09.038

APA

Jensen, A., Løhr, M., Eriksen, L., Grønbæk, M., Dorry, E., Loft, S., & Møller, P. (2012). Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity. Free Radical Biology & Medicine, 52(1), 118-25. https://doi.org/10.1016/j.freeradbiomed.2011.09.038

Vancouver

Jensen A, Løhr M, Eriksen L, Grønbæk M, Dorry E, Loft S et al. Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity. Free Radical Biology & Medicine. 2012;52(1):118-25. https://doi.org/10.1016/j.freeradbiomed.2011.09.038

Author

Jensen, Annie ; Løhr, Mille ; Eriksen, Louise ; Grønbæk, Morten ; Dorry, Elad ; Loft, Steffen ; Møller, Peter. / Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity. In: Free Radical Biology & Medicine. 2012 ; Vol. 52, No. 1. pp. 118-25.

Bibtex

@article{708942f2e0de42688c96a3f110b89adf,
title = "Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity",
abstract = "Oxidatively damaged DNA base lesions are considered to be mainly repaired by 8-oxoguanine DNA glycosylase (OGG1) mediated pathways. We investigated the effect of the OGG1 Ser326Cys polymorphism on the level and repair of oxidatively damaged DNA in mononuclear blood cells (MNBC) by means of the comet assay. We collected blood samples from 1,019 healthy subjects and genotyped for the OGG1 Ser326Cys polymorphism. We found 49 subjects homozygous for the variant genotype (Cys/Cys) and selected same numbers of age-matched subjects with the heterozygous (Ser/Cys) and homozygous wild-type genotype (Ser/Ser). Carriers of the Cys/Cys genotype had higher levels of formamidopyrimidine DNA glycosylase (FPG) sensitive sites in MNBC (0.31 ± 0.03 lesions/10(6)bp) compared to Ser/Ser (0.19 ± 0.02 lesions/10(6)bp, P",
author = "Annie Jensen and Mille L{\o}hr and Louise Eriksen and Morten Gr{\o}nb{\ae}k and Elad Dorry and Steffen Loft and Peter M{\o}ller",
note = "Copyright {\circledC} 2011 Elsevier Inc. All rights reserved.",
year = "2012",
doi = "10.1016/j.freeradbiomed.2011.09.038",
language = "English",
volume = "52",
pages = "118--25",
journal = "Free Radical Biology & Medicine",
issn = "0891-5849",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity

AU - Jensen, Annie

AU - Løhr, Mille

AU - Eriksen, Louise

AU - Grønbæk, Morten

AU - Dorry, Elad

AU - Loft, Steffen

AU - Møller, Peter

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2012

Y1 - 2012

N2 - Oxidatively damaged DNA base lesions are considered to be mainly repaired by 8-oxoguanine DNA glycosylase (OGG1) mediated pathways. We investigated the effect of the OGG1 Ser326Cys polymorphism on the level and repair of oxidatively damaged DNA in mononuclear blood cells (MNBC) by means of the comet assay. We collected blood samples from 1,019 healthy subjects and genotyped for the OGG1 Ser326Cys polymorphism. We found 49 subjects homozygous for the variant genotype (Cys/Cys) and selected same numbers of age-matched subjects with the heterozygous (Ser/Cys) and homozygous wild-type genotype (Ser/Ser). Carriers of the Cys/Cys genotype had higher levels of formamidopyrimidine DNA glycosylase (FPG) sensitive sites in MNBC (0.31 ± 0.03 lesions/10(6)bp) compared to Ser/Ser (0.19 ± 0.02 lesions/10(6)bp, P

AB - Oxidatively damaged DNA base lesions are considered to be mainly repaired by 8-oxoguanine DNA glycosylase (OGG1) mediated pathways. We investigated the effect of the OGG1 Ser326Cys polymorphism on the level and repair of oxidatively damaged DNA in mononuclear blood cells (MNBC) by means of the comet assay. We collected blood samples from 1,019 healthy subjects and genotyped for the OGG1 Ser326Cys polymorphism. We found 49 subjects homozygous for the variant genotype (Cys/Cys) and selected same numbers of age-matched subjects with the heterozygous (Ser/Cys) and homozygous wild-type genotype (Ser/Ser). Carriers of the Cys/Cys genotype had higher levels of formamidopyrimidine DNA glycosylase (FPG) sensitive sites in MNBC (0.31 ± 0.03 lesions/10(6)bp) compared to Ser/Ser (0.19 ± 0.02 lesions/10(6)bp, P

U2 - 10.1016/j.freeradbiomed.2011.09.038

DO - 10.1016/j.freeradbiomed.2011.09.038

M3 - Journal article

C2 - 22019439

VL - 52

SP - 118

EP - 125

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

IS - 1

ER -

ID: 37550900