Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort

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Standard

Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort. / Eriksen, Kirsten Thorup; Sørensen, Mette; Autrup, Herman; Vogel, Ulla; Overvad, Kim; Tjønneland, Anne; Loft, Steffen; Raaschou-Nielsen, Ole.

In: Journal of Toxicology and Environmental Health. Part A, Vol. 73, No. 9, 2010, p. 583-95.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Eriksen, KT, Sørensen, M, Autrup, H, Vogel, U, Overvad, K, Tjønneland, A, Loft, S & Raaschou-Nielsen, O 2010, 'Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort', Journal of Toxicology and Environmental Health. Part A, vol. 73, no. 9, pp. 583-95. https://doi.org/10.1080/15287390903566633

APA

Eriksen, K. T., Sørensen, M., Autrup, H., Vogel, U., Overvad, K., Tjønneland, A., ... Raaschou-Nielsen, O. (2010). Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort. Journal of Toxicology and Environmental Health. Part A, 73(9), 583-95. https://doi.org/10.1080/15287390903566633

Vancouver

Eriksen KT, Sørensen M, Autrup H, Vogel U, Overvad K, Tjønneland A et al. Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort. Journal of Toxicology and Environmental Health. Part A. 2010;73(9):583-95. https://doi.org/10.1080/15287390903566633

Author

Eriksen, Kirsten Thorup ; Sørensen, Mette ; Autrup, Herman ; Vogel, Ulla ; Overvad, Kim ; Tjønneland, Anne ; Loft, Steffen ; Raaschou-Nielsen, Ole. / Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort. In: Journal of Toxicology and Environmental Health. Part A. 2010 ; Vol. 73, No. 9. pp. 583-95.

Bibtex

@article{58530700619211df928f000ea68e967b,
title = "Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort",
abstract = "Bulky DNA adducts are considered a potential biomarker of cancer risk. In this study, the association between various lifestyle, environmental, and genetic factors and the levels of bulky DNA adducts in peripheral leukocytes was examined in a study group nested within a population-based prospective Danish cohort. At enrollment, blood samples were collected and information on lifestyle, including dietary and smoking habits, obtained. Previously, bulky DNA adducts were measured in 245 individuals who developed lung cancer and 255 control members of the cohort. Of these 500 individuals, data on 375 individuals were included in this study, excluding 125 cases, which developed lung cancer within the first 3 yr after blood sampling. Bulky DNA adduct levels were measured by 32P-postlabeling technique and polymorphisms in carcinogen metabolism and DNA repair genes were determined. Potential predictors of bulky DNA adduct levels were analyzed by univariate and multivariate regression analyses. Women tended to have higher adduct levels than men. Living in central Copenhagen and surface darkness of fried meat and fish were associated with quantitative higher adduct levels. No significant associations were found between dietary factors or smoking and DNA adduct levels. Further, the results showed no prominent associations between any of 12 genetic polymorphisms and adduct levels. Overall, our study showed only few associations between dietary, environmental, and genetic factors and levels of bulky DNA adducts measured in peripheral leukocytes in a general Danish population.",
author = "Eriksen, {Kirsten Thorup} and Mette S{\o}rensen and Herman Autrup and Ulla Vogel and Kim Overvad and Anne Tj{\o}nneland and Steffen Loft and Ole Raaschou-Nielsen",
note = "Keywords: Aged; DNA Adducts; Denmark; Environmental Exposure; Female; Forecasting; Genetic Predisposition to Disease; Genotype; Humans; Leukocytes; Life Style; Lung Neoplasms; Male; Micronucleus Tests; Middle Aged; Polymorphism, Genetic; Prospective Studies; Questionnaires; Risk Factors; Tumor Markers, Biological",
year = "2010",
doi = "10.1080/15287390903566633",
language = "English",
volume = "73",
pages = "583--95",
journal = "Journal of Toxicology and Environmental Health. Part A: Current Issues",
issn = "1528-7394",
publisher = "Taylor & Francis",
number = "9",

}

RIS

TY - JOUR

T1 - Lifestyle, environmental, and genetic predictors of bulky DNA adducts in a study population nested within a prospective Danish cohort

AU - Eriksen, Kirsten Thorup

AU - Sørensen, Mette

AU - Autrup, Herman

AU - Vogel, Ulla

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Loft, Steffen

AU - Raaschou-Nielsen, Ole

N1 - Keywords: Aged; DNA Adducts; Denmark; Environmental Exposure; Female; Forecasting; Genetic Predisposition to Disease; Genotype; Humans; Leukocytes; Life Style; Lung Neoplasms; Male; Micronucleus Tests; Middle Aged; Polymorphism, Genetic; Prospective Studies; Questionnaires; Risk Factors; Tumor Markers, Biological

PY - 2010

Y1 - 2010

N2 - Bulky DNA adducts are considered a potential biomarker of cancer risk. In this study, the association between various lifestyle, environmental, and genetic factors and the levels of bulky DNA adducts in peripheral leukocytes was examined in a study group nested within a population-based prospective Danish cohort. At enrollment, blood samples were collected and information on lifestyle, including dietary and smoking habits, obtained. Previously, bulky DNA adducts were measured in 245 individuals who developed lung cancer and 255 control members of the cohort. Of these 500 individuals, data on 375 individuals were included in this study, excluding 125 cases, which developed lung cancer within the first 3 yr after blood sampling. Bulky DNA adduct levels were measured by 32P-postlabeling technique and polymorphisms in carcinogen metabolism and DNA repair genes were determined. Potential predictors of bulky DNA adduct levels were analyzed by univariate and multivariate regression analyses. Women tended to have higher adduct levels than men. Living in central Copenhagen and surface darkness of fried meat and fish were associated with quantitative higher adduct levels. No significant associations were found between dietary factors or smoking and DNA adduct levels. Further, the results showed no prominent associations between any of 12 genetic polymorphisms and adduct levels. Overall, our study showed only few associations between dietary, environmental, and genetic factors and levels of bulky DNA adducts measured in peripheral leukocytes in a general Danish population.

AB - Bulky DNA adducts are considered a potential biomarker of cancer risk. In this study, the association between various lifestyle, environmental, and genetic factors and the levels of bulky DNA adducts in peripheral leukocytes was examined in a study group nested within a population-based prospective Danish cohort. At enrollment, blood samples were collected and information on lifestyle, including dietary and smoking habits, obtained. Previously, bulky DNA adducts were measured in 245 individuals who developed lung cancer and 255 control members of the cohort. Of these 500 individuals, data on 375 individuals were included in this study, excluding 125 cases, which developed lung cancer within the first 3 yr after blood sampling. Bulky DNA adduct levels were measured by 32P-postlabeling technique and polymorphisms in carcinogen metabolism and DNA repair genes were determined. Potential predictors of bulky DNA adduct levels were analyzed by univariate and multivariate regression analyses. Women tended to have higher adduct levels than men. Living in central Copenhagen and surface darkness of fried meat and fish were associated with quantitative higher adduct levels. No significant associations were found between dietary factors or smoking and DNA adduct levels. Further, the results showed no prominent associations between any of 12 genetic polymorphisms and adduct levels. Overall, our study showed only few associations between dietary, environmental, and genetic factors and levels of bulky DNA adducts measured in peripheral leukocytes in a general Danish population.

U2 - 10.1080/15287390903566633

DO - 10.1080/15287390903566633

M3 - Journal article

VL - 73

SP - 583

EP - 595

JO - Journal of Toxicology and Environmental Health. Part A: Current Issues

JF - Journal of Toxicology and Environmental Health. Part A: Current Issues

SN - 1528-7394

IS - 9

ER -

ID: 19792145