Long-term exposure to ambient air pollution and incidence of brain tumours: The Danish Nurse Cohort

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Long-term exposure to ambient air pollution and incidence of brain tumours : The Danish Nurse Cohort. / Jørgensen, Jeanette Therming; Johansen, Martin Søes; Ravnskjær, Line; Andersen, Klaus Kaae; Bräuner, Elvira Vaclavik; Loft, Steffen; Ketzel, Matthias; Becker, Thomas; Brandt, Jørgen; Hertel, Ole; Andersen, Zorana Jovanovic.

In: NeuroToxicology, Vol. 55, 07.2016, p. 122-130.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jørgensen, JT, Johansen, MS, Ravnskjær, L, Andersen, KK, Bräuner, EV, Loft, S, Ketzel, M, Becker, T, Brandt, J, Hertel, O & Andersen, ZJ 2016, 'Long-term exposure to ambient air pollution and incidence of brain tumours: The Danish Nurse Cohort', NeuroToxicology, vol. 55, pp. 122-130. https://doi.org/10.1016/j.neuro.2016.06.003

APA

Jørgensen, J. T., Johansen, M. S., Ravnskjær, L., Andersen, K. K., Bräuner, E. V., Loft, S., ... Andersen, Z. J. (2016). Long-term exposure to ambient air pollution and incidence of brain tumours: The Danish Nurse Cohort. NeuroToxicology, 55, 122-130. https://doi.org/10.1016/j.neuro.2016.06.003

Vancouver

Jørgensen JT, Johansen MS, Ravnskjær L, Andersen KK, Bräuner EV, Loft S et al. Long-term exposure to ambient air pollution and incidence of brain tumours: The Danish Nurse Cohort. NeuroToxicology. 2016 Jul;55:122-130. https://doi.org/10.1016/j.neuro.2016.06.003

Author

Jørgensen, Jeanette Therming ; Johansen, Martin Søes ; Ravnskjær, Line ; Andersen, Klaus Kaae ; Bräuner, Elvira Vaclavik ; Loft, Steffen ; Ketzel, Matthias ; Becker, Thomas ; Brandt, Jørgen ; Hertel, Ole ; Andersen, Zorana Jovanovic. / Long-term exposure to ambient air pollution and incidence of brain tumours : The Danish Nurse Cohort. In: NeuroToxicology. 2016 ; Vol. 55. pp. 122-130.

Bibtex

@article{ce3a2970537e429999cbe11b279890e8,
title = "Long-term exposure to ambient air pollution and incidence of brain tumours: The Danish Nurse Cohort",
abstract = "BACKGROUND: Air pollution has been considered a potent environmental risk factor for neuropathology through neuroinflammation and oxidative stress, which might also cause brain tumour formation. However, epidemiological evidence on the association between air pollution and brain tumours in humans is sparse, with no data on exposure to particles. In this study we aim to examine associations between long-term exposure to ambient air pollution and risk for development of brain tumours.METHODS: We used the Danish Nurse Cohort with 28,731 female nurses (age≥44years) recruited in 1993 or 1999 when self-reported information on lifestyle was collected. We obtained data on the incidence of brain tumours until 2013 from the Danish Cancer Register, and estimated annual mean concentrations of particulate matter with diameter<2.5μm (PM2.5), particulate matter with diameter<10μm (PM10), nitrogen oxides (NOx) and nitrogen dioxide (NO2) at the residence since 1990 using an atmospheric integrated chemistry-transport models system, and examined the association between the 3-year running mean of pollutants and brain tumour incidence using time-varying Cox regression, separately for total brain tumours, and for tumour subtypes by location (brain or meninges), and by malignancy (malignant or benign), and estimated hazard ratios and 95{\%} confidence intervals per increase in interquartile range of exposure.RESULTS: Of 25,143 tumour-free nurses at recruitment, 121 developed brain cancer during 15.7 years of follow-up. We found a weak positive association between total brain tumours and PM2.5 (1.06; 0.80-1.40 per 3.37μg/m(3)), NO2 (1.09; 0.91-1.29) per 7.5μg/m(3), and NOx (1.02; 0.93-1.12 per 10.22μg/m(3)), and none with PM10 (0.93; 0.70-1.23 per 3.31μg/m(3)). Associations with PM2.5 and NO2 were stronger for tumours located in meninges than in brain, and for benign than for malignant tumours. Finally, association of total brain tumours with PM2.5 was modified by BMI, and was statistically significantly enhanced in obese women (2.03; 1.35-3.05).CONCLUSION: We found weak evidence for association between risk of brain tumours and long-term exposure to air pollution in women older than 44 years. However, we present novel results that obese women may be susceptible, as well as a positive tendency towards elevated risk for meninges and benign tumours, which require further investigation.",
keywords = "Journal Article",
author = "J{\o}rgensen, {Jeanette Therming} and Johansen, {Martin S{\o}es} and Line Ravnskj{\ae}r and Andersen, {Klaus Kaae} and Br{\"a}uner, {Elvira Vaclavik} and Steffen Loft and Matthias Ketzel and Thomas Becker and J{\o}rgen Brandt and Ole Hertel and Andersen, {Zorana Jovanovic}",
note = "Copyright {\circledC} 2016 Elsevier B.V. All rights reserved.",
year = "2016",
month = "7",
doi = "10.1016/j.neuro.2016.06.003",
language = "English",
volume = "55",
pages = "122--130",
journal = "NeuroToxicology",
issn = "0161-813X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Long-term exposure to ambient air pollution and incidence of brain tumours

T2 - The Danish Nurse Cohort

AU - Jørgensen, Jeanette Therming

AU - Johansen, Martin Søes

AU - Ravnskjær, Line

AU - Andersen, Klaus Kaae

AU - Bräuner, Elvira Vaclavik

AU - Loft, Steffen

AU - Ketzel, Matthias

AU - Becker, Thomas

AU - Brandt, Jørgen

AU - Hertel, Ole

AU - Andersen, Zorana Jovanovic

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016/7

Y1 - 2016/7

N2 - BACKGROUND: Air pollution has been considered a potent environmental risk factor for neuropathology through neuroinflammation and oxidative stress, which might also cause brain tumour formation. However, epidemiological evidence on the association between air pollution and brain tumours in humans is sparse, with no data on exposure to particles. In this study we aim to examine associations between long-term exposure to ambient air pollution and risk for development of brain tumours.METHODS: We used the Danish Nurse Cohort with 28,731 female nurses (age≥44years) recruited in 1993 or 1999 when self-reported information on lifestyle was collected. We obtained data on the incidence of brain tumours until 2013 from the Danish Cancer Register, and estimated annual mean concentrations of particulate matter with diameter<2.5μm (PM2.5), particulate matter with diameter<10μm (PM10), nitrogen oxides (NOx) and nitrogen dioxide (NO2) at the residence since 1990 using an atmospheric integrated chemistry-transport models system, and examined the association between the 3-year running mean of pollutants and brain tumour incidence using time-varying Cox regression, separately for total brain tumours, and for tumour subtypes by location (brain or meninges), and by malignancy (malignant or benign), and estimated hazard ratios and 95% confidence intervals per increase in interquartile range of exposure.RESULTS: Of 25,143 tumour-free nurses at recruitment, 121 developed brain cancer during 15.7 years of follow-up. We found a weak positive association between total brain tumours and PM2.5 (1.06; 0.80-1.40 per 3.37μg/m(3)), NO2 (1.09; 0.91-1.29) per 7.5μg/m(3), and NOx (1.02; 0.93-1.12 per 10.22μg/m(3)), and none with PM10 (0.93; 0.70-1.23 per 3.31μg/m(3)). Associations with PM2.5 and NO2 were stronger for tumours located in meninges than in brain, and for benign than for malignant tumours. Finally, association of total brain tumours with PM2.5 was modified by BMI, and was statistically significantly enhanced in obese women (2.03; 1.35-3.05).CONCLUSION: We found weak evidence for association between risk of brain tumours and long-term exposure to air pollution in women older than 44 years. However, we present novel results that obese women may be susceptible, as well as a positive tendency towards elevated risk for meninges and benign tumours, which require further investigation.

AB - BACKGROUND: Air pollution has been considered a potent environmental risk factor for neuropathology through neuroinflammation and oxidative stress, which might also cause brain tumour formation. However, epidemiological evidence on the association between air pollution and brain tumours in humans is sparse, with no data on exposure to particles. In this study we aim to examine associations between long-term exposure to ambient air pollution and risk for development of brain tumours.METHODS: We used the Danish Nurse Cohort with 28,731 female nurses (age≥44years) recruited in 1993 or 1999 when self-reported information on lifestyle was collected. We obtained data on the incidence of brain tumours until 2013 from the Danish Cancer Register, and estimated annual mean concentrations of particulate matter with diameter<2.5μm (PM2.5), particulate matter with diameter<10μm (PM10), nitrogen oxides (NOx) and nitrogen dioxide (NO2) at the residence since 1990 using an atmospheric integrated chemistry-transport models system, and examined the association between the 3-year running mean of pollutants and brain tumour incidence using time-varying Cox regression, separately for total brain tumours, and for tumour subtypes by location (brain or meninges), and by malignancy (malignant or benign), and estimated hazard ratios and 95% confidence intervals per increase in interquartile range of exposure.RESULTS: Of 25,143 tumour-free nurses at recruitment, 121 developed brain cancer during 15.7 years of follow-up. We found a weak positive association between total brain tumours and PM2.5 (1.06; 0.80-1.40 per 3.37μg/m(3)), NO2 (1.09; 0.91-1.29) per 7.5μg/m(3), and NOx (1.02; 0.93-1.12 per 10.22μg/m(3)), and none with PM10 (0.93; 0.70-1.23 per 3.31μg/m(3)). Associations with PM2.5 and NO2 were stronger for tumours located in meninges than in brain, and for benign than for malignant tumours. Finally, association of total brain tumours with PM2.5 was modified by BMI, and was statistically significantly enhanced in obese women (2.03; 1.35-3.05).CONCLUSION: We found weak evidence for association between risk of brain tumours and long-term exposure to air pollution in women older than 44 years. However, we present novel results that obese women may be susceptible, as well as a positive tendency towards elevated risk for meninges and benign tumours, which require further investigation.

KW - Journal Article

U2 - 10.1016/j.neuro.2016.06.003

DO - 10.1016/j.neuro.2016.06.003

M3 - Journal article

C2 - 27265017

VL - 55

SP - 122

EP - 130

JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

ER -

ID: 166502045