Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project

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Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project. / Chen, Jie; Rodopoulou, Sophia; de Hoogh, Kees; Strak, Maciej; Andersen, Zorana J.; Atkinson, Richard; Bauwelinck, Mariska; Bellander, Tom; Brandt, Jorgen; Cesaroni, Giulia; Concin, Hans; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Hvidtfeldt, Ulla Arthur; Janssen, Nicole A. H.; Joeckel, Karl-Heinz; Jorgensen, Jeanette; Katsouyanni, Klea; Ketzel, Matthias; Klompmaker, Jochem O.; Lager, Anton; Leander, Karin; Liu, Shuo; Ljungman, Petter; MacDonald, Conor J.; Magnusson, Patrik K. E.; Mehta, Amar; Nagel, Gabriele; Oftedal, Bente; Pershagen, Goran; Peters, Annette; Raaschou-Nielsen, Ole; Renzi, Matteo; Rizzuto, Debora; Samoli, Evangelia; van der Schouw, Yvonne T.; Schramm, Sara; Schwarze, Per; Sigsgaard, Torben; Sørensen, Mette; Stafoggia, Massimo; Tjonneland, Anne; Vienneau, Danielle; Weinmayr, Gudrun; Wolf, Kathrin; Brunekreef, Bert; Hoek, Gerard.

In: Environmental Health Perspectives, Vol. 129, No. 4, 047009, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chen, J, Rodopoulou, S, de Hoogh, K, Strak, M, Andersen, ZJ, Atkinson, R, Bauwelinck, M, Bellander, T, Brandt, J, Cesaroni, G, Concin, H, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, UA, Janssen, NAH, Joeckel, K-H, Jorgensen, J, Katsouyanni, K, Ketzel, M, Klompmaker, JO, Lager, A, Leander, K, Liu, S, Ljungman, P, MacDonald, CJ, Magnusson, PKE, Mehta, A, Nagel, G, Oftedal, B, Pershagen, G, Peters, A, Raaschou-Nielsen, O, Renzi, M, Rizzuto, D, Samoli, E, van der Schouw, YT, Schramm, S, Schwarze, P, Sigsgaard, T, Sørensen, M, Stafoggia, M, Tjonneland, A, Vienneau, D, Weinmayr, G, Wolf, K, Brunekreef, B & Hoek, G 2021, 'Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project', Environmental Health Perspectives, vol. 129, no. 4, 047009. https://doi.org/10.1289/EHP8368

APA

Chen, J., Rodopoulou, S., de Hoogh, K., Strak, M., Andersen, Z. J., Atkinson, R., Bauwelinck, M., Bellander, T., Brandt, J., Cesaroni, G., Concin, H., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hoffmann, B., Hvidtfeldt, U. A., Janssen, N. A. H., Joeckel, K-H., ... Hoek, G. (2021). Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project. Environmental Health Perspectives, 129(4), [047009]. https://doi.org/10.1289/EHP8368

Vancouver

Chen J, Rodopoulou S, de Hoogh K, Strak M, Andersen ZJ, Atkinson R et al. Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project. Environmental Health Perspectives. 2021;129(4). 047009. https://doi.org/10.1289/EHP8368

Author

Chen, Jie ; Rodopoulou, Sophia ; de Hoogh, Kees ; Strak, Maciej ; Andersen, Zorana J. ; Atkinson, Richard ; Bauwelinck, Mariska ; Bellander, Tom ; Brandt, Jorgen ; Cesaroni, Giulia ; Concin, Hans ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara ; Hvidtfeldt, Ulla Arthur ; Janssen, Nicole A. H. ; Joeckel, Karl-Heinz ; Jorgensen, Jeanette ; Katsouyanni, Klea ; Ketzel, Matthias ; Klompmaker, Jochem O. ; Lager, Anton ; Leander, Karin ; Liu, Shuo ; Ljungman, Petter ; MacDonald, Conor J. ; Magnusson, Patrik K. E. ; Mehta, Amar ; Nagel, Gabriele ; Oftedal, Bente ; Pershagen, Goran ; Peters, Annette ; Raaschou-Nielsen, Ole ; Renzi, Matteo ; Rizzuto, Debora ; Samoli, Evangelia ; van der Schouw, Yvonne T. ; Schramm, Sara ; Schwarze, Per ; Sigsgaard, Torben ; Sørensen, Mette ; Stafoggia, Massimo ; Tjonneland, Anne ; Vienneau, Danielle ; Weinmayr, Gudrun ; Wolf, Kathrin ; Brunekreef, Bert ; Hoek, Gerard. / Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project. In: Environmental Health Perspectives. 2021 ; Vol. 129, No. 4.

Bibtex

@article{c138d7fb40594904afd2e8412ccdc346,
title = "Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project",
abstract = "BACKGROUND: Inconsistent associations between long-term exposure to particles with an aerodynamic diameterOBJECTIVES: We investigated the associations between long-term exposure to PM2.5 elemental components and mortality in a large pooled European cohort; to compare health effects of PM2.5 components estimated with two exposure modeling approaches, namely, supervised linear regression (SLR) and random forest (RF) algorithms.METHODS: We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985-2005). Residential exposure to 2010 annual average concentration of eight PM2.5 components [copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)] was estimated with Europe-wide SLR and RF models at a 100 X 100 m scale. We applied Cox proportional hazards models to investigate the associations between components and natural and cause-specific mortality. In addition, two-pollutant analyses were conducted by adjusting each component for PM2.5 mass and nitrogen dioxide (NO2) separately.RESULTS: We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RE-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both PM2.5 and NO2. HRs only remained (almost) significant for RE-modeled K and V in two-pollutant models. The HRs for V were 1.03 (95% CI: 1.02, 1.05) and 1.06 (95% CI: 1.02, 1.10) for SLR- and RF-modeled exposures, respectively, per 2 ng/m(3), adjusting for PM2.5 mass. Associations with cause-specific mortality were less consistent in two-pollutant models.CONCLUSION: Long-term exposure to V in PM2.5 was most consistently associated with increased mortality. Associations for the other components were weaker for exposure modeled with RE than SLR in two-pollutant models.",
keywords = "USE REGRESSION-MODELS, PARTICULATE MATTER, RISK, PROFILE, ESCAPE, PM2.5, MEN",
author = "Jie Chen and Sophia Rodopoulou and {de Hoogh}, Kees and Maciej Strak and Andersen, {Zorana J.} and Richard Atkinson and Mariska Bauwelinck and Tom Bellander and Jorgen Brandt and Giulia Cesaroni and Hans Concin and Daniela Fecht and Francesco Forastiere and John Gulliver and Ole Hertel and Barbara Hoffmann and Hvidtfeldt, {Ulla Arthur} and Janssen, {Nicole A. H.} and Karl-Heinz Joeckel and Jeanette Jorgensen and Klea Katsouyanni and Matthias Ketzel and Klompmaker, {Jochem O.} and Anton Lager and Karin Leander and Shuo Liu and Petter Ljungman and MacDonald, {Conor J.} and Magnusson, {Patrik K. E.} and Amar Mehta and Gabriele Nagel and Bente Oftedal and Goran Pershagen and Annette Peters and Ole Raaschou-Nielsen and Matteo Renzi and Debora Rizzuto and Evangelia Samoli and {van der Schouw}, {Yvonne T.} and Sara Schramm and Per Schwarze and Torben Sigsgaard and Mette S{\o}rensen and Massimo Stafoggia and Anne Tjonneland and Danielle Vienneau and Gudrun Weinmayr and Kathrin Wolf and Bert Brunekreef and Gerard Hoek",
year = "2021",
doi = "10.1289/EHP8368",
language = "English",
volume = "129",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "National Institute of Environmental Health Sciences",
number = "4",

}

RIS

TY - JOUR

T1 - Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project

AU - Chen, Jie

AU - Rodopoulou, Sophia

AU - de Hoogh, Kees

AU - Strak, Maciej

AU - Andersen, Zorana J.

AU - Atkinson, Richard

AU - Bauwelinck, Mariska

AU - Bellander, Tom

AU - Brandt, Jorgen

AU - Cesaroni, Giulia

AU - Concin, Hans

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hertel, Ole

AU - Hoffmann, Barbara

AU - Hvidtfeldt, Ulla Arthur

AU - Janssen, Nicole A. H.

AU - Joeckel, Karl-Heinz

AU - Jorgensen, Jeanette

AU - Katsouyanni, Klea

AU - Ketzel, Matthias

AU - Klompmaker, Jochem O.

AU - Lager, Anton

AU - Leander, Karin

AU - Liu, Shuo

AU - Ljungman, Petter

AU - MacDonald, Conor J.

AU - Magnusson, Patrik K. E.

AU - Mehta, Amar

AU - Nagel, Gabriele

AU - Oftedal, Bente

AU - Pershagen, Goran

AU - Peters, Annette

AU - Raaschou-Nielsen, Ole

AU - Renzi, Matteo

AU - Rizzuto, Debora

AU - Samoli, Evangelia

AU - van der Schouw, Yvonne T.

AU - Schramm, Sara

AU - Schwarze, Per

AU - Sigsgaard, Torben

AU - Sørensen, Mette

AU - Stafoggia, Massimo

AU - Tjonneland, Anne

AU - Vienneau, Danielle

AU - Weinmayr, Gudrun

AU - Wolf, Kathrin

AU - Brunekreef, Bert

AU - Hoek, Gerard

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Inconsistent associations between long-term exposure to particles with an aerodynamic diameterOBJECTIVES: We investigated the associations between long-term exposure to PM2.5 elemental components and mortality in a large pooled European cohort; to compare health effects of PM2.5 components estimated with two exposure modeling approaches, namely, supervised linear regression (SLR) and random forest (RF) algorithms.METHODS: We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985-2005). Residential exposure to 2010 annual average concentration of eight PM2.5 components [copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)] was estimated with Europe-wide SLR and RF models at a 100 X 100 m scale. We applied Cox proportional hazards models to investigate the associations between components and natural and cause-specific mortality. In addition, two-pollutant analyses were conducted by adjusting each component for PM2.5 mass and nitrogen dioxide (NO2) separately.RESULTS: We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RE-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both PM2.5 and NO2. HRs only remained (almost) significant for RE-modeled K and V in two-pollutant models. The HRs for V were 1.03 (95% CI: 1.02, 1.05) and 1.06 (95% CI: 1.02, 1.10) for SLR- and RF-modeled exposures, respectively, per 2 ng/m(3), adjusting for PM2.5 mass. Associations with cause-specific mortality were less consistent in two-pollutant models.CONCLUSION: Long-term exposure to V in PM2.5 was most consistently associated with increased mortality. Associations for the other components were weaker for exposure modeled with RE than SLR in two-pollutant models.

AB - BACKGROUND: Inconsistent associations between long-term exposure to particles with an aerodynamic diameterOBJECTIVES: We investigated the associations between long-term exposure to PM2.5 elemental components and mortality in a large pooled European cohort; to compare health effects of PM2.5 components estimated with two exposure modeling approaches, namely, supervised linear regression (SLR) and random forest (RF) algorithms.METHODS: We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985-2005). Residential exposure to 2010 annual average concentration of eight PM2.5 components [copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)] was estimated with Europe-wide SLR and RF models at a 100 X 100 m scale. We applied Cox proportional hazards models to investigate the associations between components and natural and cause-specific mortality. In addition, two-pollutant analyses were conducted by adjusting each component for PM2.5 mass and nitrogen dioxide (NO2) separately.RESULTS: We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RE-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both PM2.5 and NO2. HRs only remained (almost) significant for RE-modeled K and V in two-pollutant models. The HRs for V were 1.03 (95% CI: 1.02, 1.05) and 1.06 (95% CI: 1.02, 1.10) for SLR- and RF-modeled exposures, respectively, per 2 ng/m(3), adjusting for PM2.5 mass. Associations with cause-specific mortality were less consistent in two-pollutant models.CONCLUSION: Long-term exposure to V in PM2.5 was most consistently associated with increased mortality. Associations for the other components were weaker for exposure modeled with RE than SLR in two-pollutant models.

KW - USE REGRESSION-MODELS

KW - PARTICULATE MATTER

KW - RISK

KW - PROFILE

KW - ESCAPE

KW - PM2.5

KW - MEN

U2 - 10.1289/EHP8368

DO - 10.1289/EHP8368

M3 - Journal article

C2 - 33844598

VL - 129

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 4

M1 - 047009

ER -

ID: 272709077