Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Research output: Contribution to journalJournal articleResearchpeer-review

  • Sasha Bernatsky
  • Héctor A.Velásquez García
  • John J. Spinelli
  • Patrick Gaffney
  • Karin E. Smedby
  • Rosalind Ramsey-Goldman
  • Sophia S. Wang
  • Hans Olov Adami
  • Demetrius Albanes
  • Emanuele Angelucci
  • Stephen M. Ansell
  • Yan WAsmann
  • Nikolaus Becker
  • Yolanda Benavente
  • Sonja I. Berndt
  • Kimberly A. Bertrand
  • Brenda M. Birmann
  • Heiner Boeing
  • Paolo Boffetta
  • Paige M. Bracci
  • Paul Brennan
  • Angela R. Brooks-Wilson
  • James R. Cerhan
  • Stephen J. Chanock
  • Jacqueline Clavel
  • Lucia Conde
  • Karen H. Cotenbader
  • David G. Cox
  • Wendy Cozen
  • Simon Crouch
  • Anneclaire J. De Roos
  • Silvia De Sanjose
  • Simonetta Di Lollo
  • W. Ryan Diver
  • Ahmet Dogan
  • Lenka Foretova
  • Hervé Ghesquières
  • Graham G. Giles
  • Bengt Glimelius
  • Thomas M. Habermann
  • Corinne Haioun
  • Patricia Hartge
  • Theodore R. Holford
  • Elizabeth A. Holly
  • Rebecca D. Jackson
  • Rudolph Kaaks
  • Eleanor Kane
  • Rachel S. Kelly
  • Robert J. Klein
  • Peter Kraft
  • Anne Kricker
  • Qing Lan
  • Charles Lawrence
  • Mark Liebow
  • Tracy Lightfoot
  • Brian K. Link
  • Marc Maynadie
  • James McKay
  • Thierry J. Molina
  • Alain Monnereau
  • Lindsay M. Morton
  • Alexandra Nieters
  • Kari E. North
  • Anne J. Novak
  • Kenneth Offit
  • Mark P. Purdue
  • Marco Rais
  • Jacques Riby
  • Eve Roman
  • Nathaniel Rothman
  • Gilles Salles
  • Gianluca Severi
  • Richard K. Severson
  • Christine F. Skibola
  • Susan L. Slager
  • Alex Smith
  • Martyn T. Smith
  • Melissa C. Southey
  • Anthony Staines
  • Lauren R. Teras
  • Carrie A. Thompson
  • Hervé Tilly
  • Lesley F. Tinker
  • Jenny Turner
  • Claire M. Vajdic
  • Roel C.H. Vermeulen
  • Joseph Vijai
  • Paolo Vineis
  • Jarmo Virtamo
  • Zhaoming Wang
  • Stephanie Weinstein
  • Thomas E. Witzig
  • Andrew Zelenetz
  • Anne Zeleniuch-Jacquotte
  • Yawei Zhang
  • Tongzhang Zheng
  • Mariagrazia Zucca
  • Ann E. Clarke

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

Original languageEnglish
Article numbere000187
JournalLupus Science and Medicine
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2017

ID: 258839429