Male factor infertility and risk of multiple sclerosis: A register-based cohort study
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Male factor infertility and risk of multiple sclerosis : A register-based cohort study. / Glazer, Clara Helene; Tøttenborg, Sandra Søgaard; Giwercman, Aleksander; Bräuner, Elvira Vaclavik; Eisenberg, Michael L; Vassard, Ditte; Magyari, Melinda; Pinborg, Anja; Schmidt, Lone; Bonde, Jens Peter.
In: Multiple Sclerosis, Vol. 24, No. 14, 01.12.2018, p. 1835-1842.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Male factor infertility and risk of multiple sclerosis
T2 - A register-based cohort study
AU - Glazer, Clara Helene
AU - Tøttenborg, Sandra Søgaard
AU - Giwercman, Aleksander
AU - Bräuner, Elvira Vaclavik
AU - Eisenberg, Michael L
AU - Vassard, Ditte
AU - Magyari, Melinda
AU - Pinborg, Anja
AU - Schmidt, Lone
AU - Bonde, Jens Peter
PY - 2018/12/1
Y1 - 2018/12/1
N2 - BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS.OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS.METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015.RESULTS: With a median age of 34 years at baseline, 24,011 men were diagnosed with male factor infertility and 27,052 did not have male factor infertility and made up the reference group. Men diagnosed with male factor infertility had a higher risk of prevalent (odds ratio (OR) = 1.61, 95% confidence interval (95% CI) 1.04-2.51) and incident MS (hazard ratio (HR) = 1.28, 95% CI 0.76-2.17) when compared to the reference group.CONCLUSION: This nationwide cohort study has shown, for the first time, an association between male infertility and MS which may be due to underlying common etiologies such as hypogonadism, shared genetics, or a joint autoimmune component.
AB - BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS.OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS.METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015.RESULTS: With a median age of 34 years at baseline, 24,011 men were diagnosed with male factor infertility and 27,052 did not have male factor infertility and made up the reference group. Men diagnosed with male factor infertility had a higher risk of prevalent (odds ratio (OR) = 1.61, 95% confidence interval (95% CI) 1.04-2.51) and incident MS (hazard ratio (HR) = 1.28, 95% CI 0.76-2.17) when compared to the reference group.CONCLUSION: This nationwide cohort study has shown, for the first time, an association between male infertility and MS which may be due to underlying common etiologies such as hypogonadism, shared genetics, or a joint autoimmune component.
KW - Journal Article
KW - epidemiology
KW - gender
KW - Male infertility
KW - multiple sclerosis
KW - fertility
KW - semen quality
U2 - 10.1177/1352458517734069
DO - 10.1177/1352458517734069
M3 - Journal article
C2 - 29027840
VL - 24
SP - 1835
EP - 1842
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 14
ER -
ID: 184604137