Male reproductive health and environmental xenoestrogens

Research output: Contribution to journalJournal article

Standard

Male reproductive health and environmental xenoestrogens. / Toppari, J; Larsen, J C; Christiansen, Peter; Giwercman, Alexander; Grandjean, P; Guillette, L J; Jégou, B; Jensen, T K; Jouannet, P; Keiding, N; Leffers, H; McLachlan, J A; Meyer, O; Müller, Jørn; Rajpert-De Meyts, E; Scheike, T; Sharpe, R; Sumpter, J; Skakkebaek, N E.

In: Environmental Health Perspectives, Vol. 104 Suppl 4, 01.08.1996, p. 741-803.

Research output: Contribution to journalJournal article

Harvard

Toppari, J, Larsen, JC, Christiansen, P, Giwercman, A, Grandjean, P, Guillette, LJ, Jégou, B, Jensen, TK, Jouannet, P, Keiding, N, Leffers, H, McLachlan, JA, Meyer, O, Müller, J, Rajpert-De Meyts, E, Scheike, T, Sharpe, R, Sumpter, J & Skakkebaek, NE 1996, 'Male reproductive health and environmental xenoestrogens', Environmental Health Perspectives, vol. 104 Suppl 4, pp. 741-803.

APA

Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jégou, B., Jensen, T. K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J. A., Meyer, O., Müller, J., Rajpert-De Meyts, E., Scheike, T., Sharpe, R., Sumpter, J., & Skakkebaek, N. E. (1996). Male reproductive health and environmental xenoestrogens. Environmental Health Perspectives, 104 Suppl 4, 741-803.

Vancouver

Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ et al. Male reproductive health and environmental xenoestrogens. Environmental Health Perspectives. 1996 Aug 1;104 Suppl 4:741-803.

Author

Toppari, J ; Larsen, J C ; Christiansen, Peter ; Giwercman, Alexander ; Grandjean, P ; Guillette, L J ; Jégou, B ; Jensen, T K ; Jouannet, P ; Keiding, N ; Leffers, H ; McLachlan, J A ; Meyer, O ; Müller, Jørn ; Rajpert-De Meyts, E ; Scheike, T ; Sharpe, R ; Sumpter, J ; Skakkebaek, N E. / Male reproductive health and environmental xenoestrogens. In: Environmental Health Perspectives. 1996 ; Vol. 104 Suppl 4. pp. 741-803.

Bibtex

@article{261484db791d4f3797a6f31b0e0073fb,
title = "Male reproductive health and environmental xenoestrogens",
abstract = "Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention.",
author = "J Toppari and Larsen, {J C} and Peter Christiansen and Alexander Giwercman and P Grandjean and Guillette, {L J} and B J{\'e}gou and Jensen, {T K} and P Jouannet and N Keiding and H Leffers and McLachlan, {J A} and O Meyer and J{\o}rn M{\"u}ller and {Rajpert-De Meyts}, E and T Scheike and R Sharpe and J Sumpter and Skakkebaek, {N E}",
year = "1996",
month = aug,
day = "1",
language = "English",
volume = "104 Suppl 4",
pages = "741--803",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "National Institute of Environmental Health Sciences",

}

RIS

TY - JOUR

T1 - Male reproductive health and environmental xenoestrogens

AU - Toppari, J

AU - Larsen, J C

AU - Christiansen, Peter

AU - Giwercman, Alexander

AU - Grandjean, P

AU - Guillette, L J

AU - Jégou, B

AU - Jensen, T K

AU - Jouannet, P

AU - Keiding, N

AU - Leffers, H

AU - McLachlan, J A

AU - Meyer, O

AU - Müller, Jørn

AU - Rajpert-De Meyts, E

AU - Scheike, T

AU - Sharpe, R

AU - Sumpter, J

AU - Skakkebaek, N E

PY - 1996/8/1

Y1 - 1996/8/1

N2 - Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention.

AB - Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention.

M3 - Journal article

VL - 104 Suppl 4

SP - 741

EP - 803

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

ER -

ID: 34070597