Malondialdehyde and 8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkan endemic nephropathy area in Croatia--a pilot study

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Malondialdehyde and 8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkan endemic nephropathy area in Croatia--a pilot study. / Domijan, Ana-Marija; Miletić-Medved, Marica; Peraica, Maja; Loft, Steffen.

In: Collegium Antropologicum, Vol. 37, No. 4, 12.2013, p. 1195-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Domijan, A-M, Miletić-Medved, M, Peraica, M & Loft, S 2013, 'Malondialdehyde and 8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkan endemic nephropathy area in Croatia--a pilot study', Collegium Antropologicum, vol. 37, no. 4, pp. 1195-8. <http://www.ncbi.nlm.nih.gov/pubmed/24611334>

APA

Domijan, A-M., Miletić-Medved, M., Peraica, M., & Loft, S. (2013). Malondialdehyde and 8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkan endemic nephropathy area in Croatia--a pilot study. Collegium Antropologicum, 37(4), 1195-8. http://www.ncbi.nlm.nih.gov/pubmed/24611334

Vancouver

Domijan A-M, Miletić-Medved M, Peraica M, Loft S. Malondialdehyde and 8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkan endemic nephropathy area in Croatia--a pilot study. Collegium Antropologicum. 2013 Dec;37(4):1195-8.

Author

Domijan, Ana-Marija ; Miletić-Medved, Marica ; Peraica, Maja ; Loft, Steffen. / Malondialdehyde and 8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkan endemic nephropathy area in Croatia--a pilot study. In: Collegium Antropologicum. 2013 ; Vol. 37, No. 4. pp. 1195-8.

Bibtex

@article{84d93521ad14451e94b8bb4684cd9a26,
title = "Malondialdehyde and 8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkan endemic nephropathy area in Croatia--a pilot study",
abstract = "Balkan endemic nephropathy (BEN) is a human chronic tubulointerstitial renal disease that occurs in rural areas of some Balkan countries. The disease is insidious and fatal, and mostly affects persons in their sixties or seventies. BEN areas have unusually high rates of otherwise rare upper urinary tract tumors (UTT). Since extensive production of reactive oxygen species leading to oxidative stress has been implicated in tumor development, the aim of this study was to see whether oxidative stress is involved in the development of BEN and UTT. Urine samples were collected from a BEN village (N = 22) and a control village (N = 16) residents and analyzed for malondialdehyde (MDA) and 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxodG). The levels of both oxidative stress parameters were significantly higher in the BEN village residents than controls. However, there was no correlation between MDA and 8-oxodG results. Our results confirm that oxidative stress could be implicated in development of both, BEN and UTT.",
keywords = "Balkan Nephropathy, Case-Control Studies, Croatia, Deoxyguanosine, Endemic Diseases, Humans, Malondialdehyde, Pilot Projects",
author = "Ana-Marija Domijan and Marica Mileti{\'c}-Medved and Maja Peraica and Steffen Loft",
year = "2013",
month = dec,
language = "English",
volume = "37",
pages = "1195--8",
journal = "Collegium Antropologicum",
issn = "0350-6134",
publisher = "Croatian Anthropological Society",
number = "4",

}

RIS

TY - JOUR

T1 - Malondialdehyde and 8-oxo-7.8-dihydro-2'deoxyguanosine in the urine of residents from Balkan endemic nephropathy area in Croatia--a pilot study

AU - Domijan, Ana-Marija

AU - Miletić-Medved, Marica

AU - Peraica, Maja

AU - Loft, Steffen

PY - 2013/12

Y1 - 2013/12

N2 - Balkan endemic nephropathy (BEN) is a human chronic tubulointerstitial renal disease that occurs in rural areas of some Balkan countries. The disease is insidious and fatal, and mostly affects persons in their sixties or seventies. BEN areas have unusually high rates of otherwise rare upper urinary tract tumors (UTT). Since extensive production of reactive oxygen species leading to oxidative stress has been implicated in tumor development, the aim of this study was to see whether oxidative stress is involved in the development of BEN and UTT. Urine samples were collected from a BEN village (N = 22) and a control village (N = 16) residents and analyzed for malondialdehyde (MDA) and 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxodG). The levels of both oxidative stress parameters were significantly higher in the BEN village residents than controls. However, there was no correlation between MDA and 8-oxodG results. Our results confirm that oxidative stress could be implicated in development of both, BEN and UTT.

AB - Balkan endemic nephropathy (BEN) is a human chronic tubulointerstitial renal disease that occurs in rural areas of some Balkan countries. The disease is insidious and fatal, and mostly affects persons in their sixties or seventies. BEN areas have unusually high rates of otherwise rare upper urinary tract tumors (UTT). Since extensive production of reactive oxygen species leading to oxidative stress has been implicated in tumor development, the aim of this study was to see whether oxidative stress is involved in the development of BEN and UTT. Urine samples were collected from a BEN village (N = 22) and a control village (N = 16) residents and analyzed for malondialdehyde (MDA) and 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxodG). The levels of both oxidative stress parameters were significantly higher in the BEN village residents than controls. However, there was no correlation between MDA and 8-oxodG results. Our results confirm that oxidative stress could be implicated in development of both, BEN and UTT.

KW - Balkan Nephropathy

KW - Case-Control Studies

KW - Croatia

KW - Deoxyguanosine

KW - Endemic Diseases

KW - Humans

KW - Malondialdehyde

KW - Pilot Projects

M3 - Journal article

C2 - 24611334

VL - 37

SP - 1195

EP - 1198

JO - Collegium Antropologicum

JF - Collegium Antropologicum

SN - 0350-6134

IS - 4

ER -

ID: 120020705