Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats
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- Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats_(accepted_version)
Accepted author manuscript, 1.48 MB, PDF document
Objective:Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT); a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side-effects of ECT.Methods:We measured sensitive markers of systemic and CNS oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS); an animal model of ECT. Due to previous observations that link hypothalamic-pituitary-adrenal (HPA)-axis activity and age to DNA/RNA damage from oxidation, groups of young and middle-aged male animals were included, and markers of HPA-axis activity were measured.Results:ECS induced weight loss, corticosterone increases (only in middle-aged animals), and decreased cerebral glucocorticoid receptor mRNA expression, while largely leaving the markers of systemic and CNS DNA/RNA damage from oxidation unaltered.Conclusion:These results suggest that ECS is not associated with any lasting effects on oxidative stress on nucleic acids neither in young or middle-aged rats.
Original language | English |
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Journal | Acta Neuropsychiatrica |
Volume | 31 |
Issue number | 6 |
Pages (from-to) | 287-293 |
Number of pages | 7 |
ISSN | 0924-2708 |
DOIs | |
Publication status | Published - 2019 |
- DNA repair, Electroconvulsive stimulations, HPA-axis, nucleic acids, oxidative stress
Research areas
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