Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns

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Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns. / Pedersen, Marie; Halldorsson, Thorhallur I; Autrup, Herman; Brouwer, Abraham; Besselink, Harrie; Loft, Steffen; Knudsen, Lisbeth E.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 734, No. 1-2, 2012, p. 12-19.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pedersen, M, Halldorsson, TI, Autrup, H, Brouwer, A, Besselink, H, Loft, S & Knudsen, LE 2012, 'Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 734, no. 1-2, pp. 12-19. https://doi.org/10.1016/j.mrfmmm.2012.04.006

APA

Pedersen, M., Halldorsson, T. I., Autrup, H., Brouwer, A., Besselink, H., Loft, S., & Knudsen, L. E. (2012). Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 734(1-2), 12-19. https://doi.org/10.1016/j.mrfmmm.2012.04.006

Vancouver

Pedersen M, Halldorsson TI, Autrup H, Brouwer A, Besselink H, Loft S et al. Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2012;734(1-2):12-19. https://doi.org/10.1016/j.mrfmmm.2012.04.006

Author

Pedersen, Marie ; Halldorsson, Thorhallur I ; Autrup, Herman ; Brouwer, Abraham ; Besselink, Harrie ; Loft, Steffen ; Knudsen, Lisbeth E. / Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns. In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2012 ; Vol. 734, No. 1-2. pp. 12-19.

Bibtex

@article{3b17208aba214df183d42ded037e5d3b,

title = "Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns",

abstract = "Maternal diet can contribute to carcinogenic exposures and also modify effects of environmental exposures on maternal and fetal genetic stability. In this study, associations between maternal diet and the levels of dioxin-like plasma activity, bulky DNA adducts in white blood cells and micronuclei (MN) in lymphocytes from mother to newborns were examined. From 98 pregnant women living in the greater area of Copenhagen, Denmark in 2006-2007, maternal peripheral blood and umbilical cord blood were collected, together with information on health, environmental exposure and lifestyle. Maternal diet was estimated on the basis of maternal food frequency questionnaire (FFQ) completed by the end of pregnancy. Biomarkers were detected in paired blood samples through the dioxin-responsive chemical-activated luciferase expression (CALUX)({\textregistered}) bioassay, (32)P-postlabelling technique and cytokinesis-block MN assay. Maternal preference for meats with dark surface were significantly associated with higher bulky DNA adducts in both maternal ({\ss} 95%CI; 0.46 (0.08, 0.84)) and cord blood ({\ss} 95%CI; 0.46 (0.05, 0.86)) before and after adjustment for potential confounders. No other significant associations between the 18 dietary variables and the biomarkers measured in maternal and fetal samples were identified. The present study suggests that maternal intake of meats with dark surface contributes to the bulky DNA adduct levels in maternal and umbilical cord blood. Relationship between food preparation and bulky DNA adducts appear to be captured by a FFQ while potential associations for other biomarkers might be more complex or need larger sample size.",

author = "Marie Pedersen and Halldorsson, {Thorhallur I} and Herman Autrup and Abraham Brouwer and Harrie Besselink and Steffen Loft and Knudsen, {Lisbeth E}",

year = "2012",

doi = "10.1016/j.mrfmmm.2012.04.006",

language = "English",

volume = "734",

pages = "12--19",

journal = "Mutation Research Letters",

issn = "0027-5107",

publisher = "Elsevier",

number = "1-2",

}

RIS

TY - JOUR

T1 - Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns

AU - Pedersen, Marie

AU - Halldorsson, Thorhallur I

AU - Autrup, Herman

AU - Brouwer, Abraham

AU - Besselink, Harrie

AU - Loft, Steffen

AU - Knudsen, Lisbeth E

PY - 2012

Y1 - 2012

N2 - Maternal diet can contribute to carcinogenic exposures and also modify effects of environmental exposures on maternal and fetal genetic stability. In this study, associations between maternal diet and the levels of dioxin-like plasma activity, bulky DNA adducts in white blood cells and micronuclei (MN) in lymphocytes from mother to newborns were examined. From 98 pregnant women living in the greater area of Copenhagen, Denmark in 2006-2007, maternal peripheral blood and umbilical cord blood were collected, together with information on health, environmental exposure and lifestyle. Maternal diet was estimated on the basis of maternal food frequency questionnaire (FFQ) completed by the end of pregnancy. Biomarkers were detected in paired blood samples through the dioxin-responsive chemical-activated luciferase expression (CALUX)(®) bioassay, (32)P-postlabelling technique and cytokinesis-block MN assay. Maternal preference for meats with dark surface were significantly associated with higher bulky DNA adducts in both maternal (ß 95%CI; 0.46 (0.08, 0.84)) and cord blood (ß 95%CI; 0.46 (0.05, 0.86)) before and after adjustment for potential confounders. No other significant associations between the 18 dietary variables and the biomarkers measured in maternal and fetal samples were identified. The present study suggests that maternal intake of meats with dark surface contributes to the bulky DNA adduct levels in maternal and umbilical cord blood. Relationship between food preparation and bulky DNA adducts appear to be captured by a FFQ while potential associations for other biomarkers might be more complex or need larger sample size.

AB - Maternal diet can contribute to carcinogenic exposures and also modify effects of environmental exposures on maternal and fetal genetic stability. In this study, associations between maternal diet and the levels of dioxin-like plasma activity, bulky DNA adducts in white blood cells and micronuclei (MN) in lymphocytes from mother to newborns were examined. From 98 pregnant women living in the greater area of Copenhagen, Denmark in 2006-2007, maternal peripheral blood and umbilical cord blood were collected, together with information on health, environmental exposure and lifestyle. Maternal diet was estimated on the basis of maternal food frequency questionnaire (FFQ) completed by the end of pregnancy. Biomarkers were detected in paired blood samples through the dioxin-responsive chemical-activated luciferase expression (CALUX)(®) bioassay, (32)P-postlabelling technique and cytokinesis-block MN assay. Maternal preference for meats with dark surface were significantly associated with higher bulky DNA adducts in both maternal (ß 95%CI; 0.46 (0.08, 0.84)) and cord blood (ß 95%CI; 0.46 (0.05, 0.86)) before and after adjustment for potential confounders. No other significant associations between the 18 dietary variables and the biomarkers measured in maternal and fetal samples were identified. The present study suggests that maternal intake of meats with dark surface contributes to the bulky DNA adduct levels in maternal and umbilical cord blood. Relationship between food preparation and bulky DNA adducts appear to be captured by a FFQ while potential associations for other biomarkers might be more complex or need larger sample size.

U2 - 10.1016/j.mrfmmm.2012.04.006

DO - 10.1016/j.mrfmmm.2012.04.006

M3 - Journal article

C2 - 22561210

VL - 734

SP - 12

EP - 19

JO - Mutation Research Letters

JF - Mutation Research Letters

SN - 0027-5107

IS - 1-2

ER -

ID: 38494806

Department of Public Health