Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism

Research output: Contribution to journalJournal articleResearchpeer-review

  • Morten Søndergaard Jensen
  • Cristina Rebordosa
  • Ane Marie Thulstrup
  • Gunnar Toft
  • Henrik Toft Sørensen
  • Bonde, Jens Peter
  • Tine Brink Henriksen
  • Jørn Olsen
Cyclooxygenase (COX) inhibitors-acetaminophen, ibuprofen and acetylsalicylic acid-have endocrine-disruptive properties in the rainbow trout. In humans, aspirin blocks the androgen response to human chorionic gonadotropin (hCG), and, because hCG-stimulated androgen production in utero is crucial for normal testicular descent, exposure to COX inhibitors at vulnerable times during gestation may impair testicular descent. We examined whether prenatal exposure to acetaminophen, ibuprofen, and acetylsalicylic acid was associated with increased occurrence of cryptorchidism.
Original languageEnglish
Issue number6
Pages (from-to)779-85
Number of pages7
Publication statusPublished - 1 Nov 2010

ID: 40220557