Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition

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Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition. / Waller, Katja Linda; Mortensen, Erik Lykke; Avlund, Kirsten; Fagerlund, Birgitte; Lauritzen, Martin; Gammeltoft, Steen; Jennum, Poul.

In: Nature and Science of Sleep, Vol. 8, 2016, p. 47-53.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Waller, KL, Mortensen, EL, Avlund, K, Fagerlund, B, Lauritzen, M, Gammeltoft, S & Jennum, P 2016, 'Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition', Nature and Science of Sleep, vol. 8, pp. 47-53. https://doi.org/10.2147/NSS.S75946

APA

Waller, K. L., Mortensen, E. L., Avlund, K., Fagerlund, B., Lauritzen, M., Gammeltoft, S., & Jennum, P. (2016). Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition. Nature and Science of Sleep, 8, 47-53. https://doi.org/10.2147/NSS.S75946

Vancouver

Waller KL, Mortensen EL, Avlund K, Fagerlund B, Lauritzen M, Gammeltoft S et al. Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition. Nature and Science of Sleep. 2016;8:47-53. https://doi.org/10.2147/NSS.S75946

Author

Waller, Katja Linda ; Mortensen, Erik Lykke ; Avlund, Kirsten ; Fagerlund, Birgitte ; Lauritzen, Martin ; Gammeltoft, Steen ; Jennum, Poul. / Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition. In: Nature and Science of Sleep. 2016 ; Vol. 8. pp. 47-53.

Bibtex

@article{9314e91a7b774725bd8b71061650faf7,
title = "Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition",
abstract = "Previous studies have reported an association between circadian disturbances and age-related cognitive impairment. The aim was to study the 24-hour profiles of melatonin and cortisol in relation to cognitive function in middle-aged male subjects. Fifty healthy middle-aged males born in 1953 were recruited from a population-based cohort based on previous cognitive assessments in young adulthood and late midlife. The sample included 24 cognitively high-functioning and 26 cognitively impaired participants. Saliva samples were collected every 4 hours over a 24-hour period and analyzed for cortisol and melatonin levels by immunoassay. All participants exhibited clear circadian rhythms of salivary melatonin and cortisol. Salivary melatonin concentrations had a nocturnal peak at approximately 4 am. The median nocturnal melatonin response at 4 am was significantly lower in the cognitively impaired group than in the high-functioning group (-4.6 pg/mL, 95{\%} CI: -7.84, -1.36, P=0.006). The 24-hour mean melatonin concentration (high-functioning group: 4.80±0.70 pg/mL, vs cognitively impaired group: 4.81±0.76 pg/mL; P>0.05) (or the area under the curve, AUC) was not significantly different between the two groups. Cortisol levels were low during the night, and peaked at approximately 8 am. Median cortisol concentrations were similar at all times, as were the 24-hour mean cortisol concentrations and AUC. To the best of our knowledge, ours is the first study to assess circadian measures (ie, melatonin and cortisol) in healthy middle-aged men with different cognitive trajectories in midlife. We found evidence of altered circadian rhythms with a reduced nocturnal melatonin response at 4 am in men with cognitive impairment. The 24-hour concentration and AUC of melatonin and cortisol were similar in the cognitively high-functioning group and in the cognitively impaired.",
keywords = "Journal Article",
author = "Waller, {Katja Linda} and Mortensen, {Erik Lykke} and Kirsten Avlund and Birgitte Fagerlund and Martin Lauritzen and Steen Gammeltoft and Poul Jennum",
year = "2016",
doi = "10.2147/NSS.S75946",
language = "English",
volume = "8",
pages = "47--53",
journal = "Nature and Science of Sleep",
issn = "1179-1608",
publisher = "Dove Medical Press Ltd",

}

RIS

TY - JOUR

T1 - Melatonin and cortisol profiles in late midlife and their association with age-related changes in cognition

AU - Waller, Katja Linda

AU - Mortensen, Erik Lykke

AU - Avlund, Kirsten

AU - Fagerlund, Birgitte

AU - Lauritzen, Martin

AU - Gammeltoft, Steen

AU - Jennum, Poul

PY - 2016

Y1 - 2016

N2 - Previous studies have reported an association between circadian disturbances and age-related cognitive impairment. The aim was to study the 24-hour profiles of melatonin and cortisol in relation to cognitive function in middle-aged male subjects. Fifty healthy middle-aged males born in 1953 were recruited from a population-based cohort based on previous cognitive assessments in young adulthood and late midlife. The sample included 24 cognitively high-functioning and 26 cognitively impaired participants. Saliva samples were collected every 4 hours over a 24-hour period and analyzed for cortisol and melatonin levels by immunoassay. All participants exhibited clear circadian rhythms of salivary melatonin and cortisol. Salivary melatonin concentrations had a nocturnal peak at approximately 4 am. The median nocturnal melatonin response at 4 am was significantly lower in the cognitively impaired group than in the high-functioning group (-4.6 pg/mL, 95% CI: -7.84, -1.36, P=0.006). The 24-hour mean melatonin concentration (high-functioning group: 4.80±0.70 pg/mL, vs cognitively impaired group: 4.81±0.76 pg/mL; P>0.05) (or the area under the curve, AUC) was not significantly different between the two groups. Cortisol levels were low during the night, and peaked at approximately 8 am. Median cortisol concentrations were similar at all times, as were the 24-hour mean cortisol concentrations and AUC. To the best of our knowledge, ours is the first study to assess circadian measures (ie, melatonin and cortisol) in healthy middle-aged men with different cognitive trajectories in midlife. We found evidence of altered circadian rhythms with a reduced nocturnal melatonin response at 4 am in men with cognitive impairment. The 24-hour concentration and AUC of melatonin and cortisol were similar in the cognitively high-functioning group and in the cognitively impaired.

AB - Previous studies have reported an association between circadian disturbances and age-related cognitive impairment. The aim was to study the 24-hour profiles of melatonin and cortisol in relation to cognitive function in middle-aged male subjects. Fifty healthy middle-aged males born in 1953 were recruited from a population-based cohort based on previous cognitive assessments in young adulthood and late midlife. The sample included 24 cognitively high-functioning and 26 cognitively impaired participants. Saliva samples were collected every 4 hours over a 24-hour period and analyzed for cortisol and melatonin levels by immunoassay. All participants exhibited clear circadian rhythms of salivary melatonin and cortisol. Salivary melatonin concentrations had a nocturnal peak at approximately 4 am. The median nocturnal melatonin response at 4 am was significantly lower in the cognitively impaired group than in the high-functioning group (-4.6 pg/mL, 95% CI: -7.84, -1.36, P=0.006). The 24-hour mean melatonin concentration (high-functioning group: 4.80±0.70 pg/mL, vs cognitively impaired group: 4.81±0.76 pg/mL; P>0.05) (or the area under the curve, AUC) was not significantly different between the two groups. Cortisol levels were low during the night, and peaked at approximately 8 am. Median cortisol concentrations were similar at all times, as were the 24-hour mean cortisol concentrations and AUC. To the best of our knowledge, ours is the first study to assess circadian measures (ie, melatonin and cortisol) in healthy middle-aged men with different cognitive trajectories in midlife. We found evidence of altered circadian rhythms with a reduced nocturnal melatonin response at 4 am in men with cognitive impairment. The 24-hour concentration and AUC of melatonin and cortisol were similar in the cognitively high-functioning group and in the cognitively impaired.

KW - Journal Article

U2 - 10.2147/NSS.S75946

DO - 10.2147/NSS.S75946

M3 - Journal article

VL - 8

SP - 47

EP - 53

JO - Nature and Science of Sleep

JF - Nature and Science of Sleep

SN - 1179-1608

ER -

ID: 164825189