Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Migraine with aura and risk of silent brain infarcts and white matter hyperintensities : an MRI study. / Gaist, David; Garde, Ellen; Blaabjerg, Morten; Nielsen, Helle Hvarness; Krøigård, Thomas; Østergaard, Kamilla; Møller, Harald S.; Hjelmborg, Jacob; Madsen, Camilla Gøbel; Iversen, Pernille; Kyvik, Kirsten Ohm; Siebner, Hartwig Roman; Ashina, Messoud.

In: Brain, Vol. 139, No. 7, 05.2016, p. 2015-2023.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Gaist, D, Garde, E, Blaabjerg, M, Nielsen, HH, Krøigård, T, Østergaard, K, Møller, HS, Hjelmborg, J, Madsen, CG, Iversen, P, Kyvik, KO, Siebner, HR & Ashina, M 2016, 'Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study', Brain, vol. 139, no. 7, pp. 2015-2023. https://doi.org/10.1093/brain/aww099

APA

Gaist, D., Garde, E., Blaabjerg, M., Nielsen, H. H., Krøigård, T., Østergaard, K., ... Ashina, M. (2016). Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study. Brain, 139(7), 2015-2023. https://doi.org/10.1093/brain/aww099

Vancouver

Gaist D, Garde E, Blaabjerg M, Nielsen HH, Krøigård T, Østergaard K et al. Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study. Brain. 2016 May;139(7):2015-2023. https://doi.org/10.1093/brain/aww099

Author

Gaist, David ; Garde, Ellen ; Blaabjerg, Morten ; Nielsen, Helle Hvarness ; Krøigård, Thomas ; Østergaard, Kamilla ; Møller, Harald S. ; Hjelmborg, Jacob ; Madsen, Camilla Gøbel ; Iversen, Pernille ; Kyvik, Kirsten Ohm ; Siebner, Hartwig Roman ; Ashina, Messoud. / Migraine with aura and risk of silent brain infarcts and white matter hyperintensities : an MRI study. In: Brain. 2016 ; Vol. 139, No. 7. pp. 2015-2023.

Bibtex

@article{f253a38cab3740c1a84229298299f4e7,
title = "Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study",
abstract = "A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30-60 years identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins were invited to participate in a telephone-based interview conducted by physicians. Headache diagnoses were established according to the International Headache Society criteria. Cases with migraine with aura, their co-twins, and unrelated migraine-free twins (controls) were invited to a brain magnetic resonance imaging scan performed at a single centre. Brain scans were assessed for the presence of infarcts, and white matter hyperintensities (visual rating scales and volumetric analyses) blinded to headache diagnoses. Comparisons were based on 172 cases, 34 co-twins, and 139 control subjects. Compared with control subjects, cases did not differ with regard to frequency of silent brain infarcts (four cases versus one control), periventricular white matter hyperintensity scores [adjusted mean difference (95{\%} confidence interval): -0.1 (-0.5 to 0.2)] or deep white matter hyperintensity scores [adjusted mean difference (95{\%} confidence interval): 0.1 (-0.8 to 1.1)] assessed by Scheltens' scale. Cases had a slightly higher total white matter hyperintensity volume compared with controls [adjusted mean difference (95{\%} confidence interval): 0.17 (-0.08 to 0.41) cm(3)] and a similar difference was present in analyses restricted to twin pairs discordant for migraine with aura [adjusted mean difference 0.21 (-0.20 to 0.63)], but these differences did not reach statistical significance. We found no evidence of an association between silent brain infarcts, white matter hyperintensities, and migraine with aura.",
keywords = "Journal Article",
author = "David Gaist and Ellen Garde and Morten Blaabjerg and Nielsen, {Helle Hvarness} and Thomas Kr{\o}ig{\aa}rd and Kamilla {\O}stergaard and M{\o}ller, {Harald S.} and Jacob Hjelmborg and Madsen, {Camilla G{\o}bel} and Pernille Iversen and Kyvik, {Kirsten Ohm} and Siebner, {Hartwig Roman} and Messoud Ashina",
note = "{\circledC} The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.",
year = "2016",
month = "5",
doi = "10.1093/brain/aww099",
language = "English",
volume = "139",
pages = "2015--2023",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Migraine with aura and risk of silent brain infarcts and white matter hyperintensities

T2 - an MRI study

AU - Gaist, David

AU - Garde, Ellen

AU - Blaabjerg, Morten

AU - Nielsen, Helle Hvarness

AU - Krøigård, Thomas

AU - Østergaard, Kamilla

AU - Møller, Harald S.

AU - Hjelmborg, Jacob

AU - Madsen, Camilla Gøbel

AU - Iversen, Pernille

AU - Kyvik, Kirsten Ohm

AU - Siebner, Hartwig Roman

AU - Ashina, Messoud

N1 - © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.

PY - 2016/5

Y1 - 2016/5

N2 - A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30-60 years identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins were invited to participate in a telephone-based interview conducted by physicians. Headache diagnoses were established according to the International Headache Society criteria. Cases with migraine with aura, their co-twins, and unrelated migraine-free twins (controls) were invited to a brain magnetic resonance imaging scan performed at a single centre. Brain scans were assessed for the presence of infarcts, and white matter hyperintensities (visual rating scales and volumetric analyses) blinded to headache diagnoses. Comparisons were based on 172 cases, 34 co-twins, and 139 control subjects. Compared with control subjects, cases did not differ with regard to frequency of silent brain infarcts (four cases versus one control), periventricular white matter hyperintensity scores [adjusted mean difference (95% confidence interval): -0.1 (-0.5 to 0.2)] or deep white matter hyperintensity scores [adjusted mean difference (95% confidence interval): 0.1 (-0.8 to 1.1)] assessed by Scheltens' scale. Cases had a slightly higher total white matter hyperintensity volume compared with controls [adjusted mean difference (95% confidence interval): 0.17 (-0.08 to 0.41) cm(3)] and a similar difference was present in analyses restricted to twin pairs discordant for migraine with aura [adjusted mean difference 0.21 (-0.20 to 0.63)], but these differences did not reach statistical significance. We found no evidence of an association between silent brain infarcts, white matter hyperintensities, and migraine with aura.

AB - A small number of population-based studies reported an association between migraine with aura and risk of silent brain infarcts and white matter hyperintensities in females. We investigated these relations in a population-based sample of female twins. We contacted female twins ages 30-60 years identified through the population-based Danish Twin Registry. Based on questionnaire responses, twins were invited to participate in a telephone-based interview conducted by physicians. Headache diagnoses were established according to the International Headache Society criteria. Cases with migraine with aura, their co-twins, and unrelated migraine-free twins (controls) were invited to a brain magnetic resonance imaging scan performed at a single centre. Brain scans were assessed for the presence of infarcts, and white matter hyperintensities (visual rating scales and volumetric analyses) blinded to headache diagnoses. Comparisons were based on 172 cases, 34 co-twins, and 139 control subjects. Compared with control subjects, cases did not differ with regard to frequency of silent brain infarcts (four cases versus one control), periventricular white matter hyperintensity scores [adjusted mean difference (95% confidence interval): -0.1 (-0.5 to 0.2)] or deep white matter hyperintensity scores [adjusted mean difference (95% confidence interval): 0.1 (-0.8 to 1.1)] assessed by Scheltens' scale. Cases had a slightly higher total white matter hyperintensity volume compared with controls [adjusted mean difference (95% confidence interval): 0.17 (-0.08 to 0.41) cm(3)] and a similar difference was present in analyses restricted to twin pairs discordant for migraine with aura [adjusted mean difference 0.21 (-0.20 to 0.63)], but these differences did not reach statistical significance. We found no evidence of an association between silent brain infarcts, white matter hyperintensities, and migraine with aura.

KW - Journal Article

U2 - 10.1093/brain/aww099

DO - 10.1093/brain/aww099

M3 - Journal article

VL - 139

SP - 2015

EP - 2023

JO - Brain

JF - Brain

SN - 0006-8950

IS - 7

ER -

ID: 171656564