Modelling of human transplacental transport as performed in Copenhagen, Denmark
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Modelling of human transplacental transport as performed in Copenhagen, Denmark. / Mathiesen, Line; Mørck, Thit Aarøe; Zuri, Giuseppina; Guerra Andersen, Maria Helena; Pehrson, Caroline; Frederiksen, Marie; Mose, Tina; Rytting, Erik; Poulsen, Marie S; Nielsen, Jeanette Kolstrup Søgaard; Knudsen, Lisbeth E.
In: Basic & Clinical Pharmacology & Toxicology, Vol. 115, No. 1, 07.2014, p. 93-100.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Modelling of human transplacental transport as performed in Copenhagen, Denmark
AU - Mathiesen, Line
AU - Mørck, Thit Aarøe
AU - Zuri, Giuseppina
AU - Guerra Andersen, Maria Helena
AU - Pehrson, Caroline
AU - Frederiksen, Marie
AU - Mose, Tina
AU - Rytting, Erik
AU - Poulsen, Marie S
AU - Nielsen, Jeanette Kolstrup Søgaard
AU - Knudsen, Lisbeth E
N1 - © 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
PY - 2014/7
Y1 - 2014/7
N2 - Placenta perfusion models are very effective when studying the placental mechanisms in order to extrapolate to real-life situations. The models are most often used to investigate the transport of substances between mother and foetus, including the potential metabolism of these. We have studied the relationships between maternal and foetal exposures to various compounds including pollutants such as polychlorinated biphenyls, polybrominated flame retardants, nanoparticles as well as recombinant human antibodies. The compounds have been studied in the human placenta perfusion model and to some extent in vitro with an established human monolayer trophoblast cell culture model. Results from our studies distinguish placental transport of substances by physicochemical properties, adsorption to placental tissue, binding to transport and receptor proteins and metabolism. We have collected data from different classes of chemicals and nanoparticles for comparisons across chemical structures as well as different test systems. Our test systems are based on human material to bypass the extrapolation from animal data. By combining data from our two test systems, we are able to rank and compare the transport of different classes of substances according to their transport ability. Ultimately, human data including measurements in cord blood contribute to the study of placental transport.
AB - Placenta perfusion models are very effective when studying the placental mechanisms in order to extrapolate to real-life situations. The models are most often used to investigate the transport of substances between mother and foetus, including the potential metabolism of these. We have studied the relationships between maternal and foetal exposures to various compounds including pollutants such as polychlorinated biphenyls, polybrominated flame retardants, nanoparticles as well as recombinant human antibodies. The compounds have been studied in the human placenta perfusion model and to some extent in vitro with an established human monolayer trophoblast cell culture model. Results from our studies distinguish placental transport of substances by physicochemical properties, adsorption to placental tissue, binding to transport and receptor proteins and metabolism. We have collected data from different classes of chemicals and nanoparticles for comparisons across chemical structures as well as different test systems. Our test systems are based on human material to bypass the extrapolation from animal data. By combining data from our two test systems, we are able to rank and compare the transport of different classes of substances according to their transport ability. Ultimately, human data including measurements in cord blood contribute to the study of placental transport.
U2 - 10.1111/bcpt.12228
DO - 10.1111/bcpt.12228
M3 - Journal article
C2 - 24646015
VL - 115
SP - 93
EP - 100
JO - Basic and Clinical Pharmacology and Toxicology
JF - Basic and Clinical Pharmacology and Toxicology
SN - 1742-7835
IS - 1
ER -
ID: 120345065