Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease

Research output: Contribution to journalJournal articlepeer-review

Standard

Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease. / Frederiksen, Kristian S.; Madsen, Karine; Andersen, Birgitte B.; Beyer, Nina; Garde, Ellen; Høgh, Peter; Waldemar, Gunhild; Hasselbalch, Steen G.; Law, Ian.

In: Alzheimer's & Dementia: Translational Research & Clinical Interventions, Vol. 5, No. 1, 2019, p. 208-215.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Frederiksen, KS, Madsen, K, Andersen, BB, Beyer, N, Garde, E, Høgh, P, Waldemar, G, Hasselbalch, SG & Law, I 2019, 'Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease', Alzheimer's & Dementia: Translational Research & Clinical Interventions, vol. 5, no. 1, pp. 208-215. https://doi.org/10.1016/j.trci.2019.04.006

APA

Frederiksen, K. S., Madsen, K., Andersen, B. B., Beyer, N., Garde, E., Høgh, P., Waldemar, G., Hasselbalch, S. G., & Law, I. (2019). Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5(1), 208-215. https://doi.org/10.1016/j.trci.2019.04.006

Vancouver

Frederiksen KS, Madsen K, Andersen BB, Beyer N, Garde E, Høgh P et al. Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2019;5(1):208-215. https://doi.org/10.1016/j.trci.2019.04.006

Author

Frederiksen, Kristian S. ; Madsen, Karine ; Andersen, Birgitte B. ; Beyer, Nina ; Garde, Ellen ; Høgh, Peter ; Waldemar, Gunhild ; Hasselbalch, Steen G. ; Law, Ian. / Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease. In: Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2019 ; Vol. 5, No. 1. pp. 208-215.

Bibtex

@article{721727096484463b913520c02c26585d,
title = "Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease",
abstract = "Introduction: Animal models of Alzheimer's disease show that exercise may modify β-amyloid (Aβ) deposition. We examined the effect of a 16-week exercise intervention on cortical Aβ in patients with mild-to-moderate Alzheimer's disease. Methods: Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical Aβ, and quantified using standardized uptake value rations (SUVRs). Results: The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini–Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. Discussion: The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.",
keywords = "11C-PiB-PET, Aerobic exercise, Alzheimer's disease, Dementia, Exercise, Intervention, PET, Randomized, β-amyloid",
author = "Frederiksen, {Kristian S.} and Karine Madsen and Andersen, {Birgitte B.} and Nina Beyer and Ellen Garde and Peter H{\o}gh and Gunhild Waldemar and Hasselbalch, {Steen G.} and Ian Law",
year = "2019",
doi = "10.1016/j.trci.2019.04.006",
language = "English",
volume = "5",
pages = "208--215",
journal = "Alzheimer's & Dementia: Translational Research & Clinical Interventions",
issn = "2352-8737",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease

AU - Frederiksen, Kristian S.

AU - Madsen, Karine

AU - Andersen, Birgitte B.

AU - Beyer, Nina

AU - Garde, Ellen

AU - Høgh, Peter

AU - Waldemar, Gunhild

AU - Hasselbalch, Steen G.

AU - Law, Ian

PY - 2019

Y1 - 2019

N2 - Introduction: Animal models of Alzheimer's disease show that exercise may modify β-amyloid (Aβ) deposition. We examined the effect of a 16-week exercise intervention on cortical Aβ in patients with mild-to-moderate Alzheimer's disease. Methods: Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical Aβ, and quantified using standardized uptake value rations (SUVRs). Results: The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini–Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. Discussion: The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.

AB - Introduction: Animal models of Alzheimer's disease show that exercise may modify β-amyloid (Aβ) deposition. We examined the effect of a 16-week exercise intervention on cortical Aβ in patients with mild-to-moderate Alzheimer's disease. Methods: Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical Aβ, and quantified using standardized uptake value rations (SUVRs). Results: The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini–Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. Discussion: The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.

KW - 11C-PiB-PET

KW - Aerobic exercise

KW - Alzheimer's disease

KW - Dementia

KW - Exercise

KW - Intervention

KW - PET

KW - Randomized

KW - β-amyloid

U2 - 10.1016/j.trci.2019.04.006

DO - 10.1016/j.trci.2019.04.006

M3 - Journal article

C2 - 31198839

AN - SCOPUS:85066842311

VL - 5

SP - 208

EP - 215

JO - Alzheimer's & Dementia: Translational Research & Clinical Interventions

JF - Alzheimer's & Dementia: Translational Research & Clinical Interventions

SN - 2352-8737

IS - 1

ER -

ID: 239159471