Neonatal levels of cytokines and risk of autism spectrum disorders: An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank

Research output: Contribution to journalJournal articleResearchpeer-review

Morsi Abdallah, Nanna Larsen, Erik L Mortensen, Hjördis Ó Atladóttir, Bent Nørgaard-Pedersen, Eva Cecilie Bonefeld-Jørgensen, Jakob Grove, David M Hougaard

The aim of the study was to analyze cytokine profiles in neonatal dried blood samples (n-DBSS) retrieved from The Danish Newborn Screening Biobank of children developing Autism Spectrum Disorders (ASD) later in life and controls. Samples of 359 ASD cases and 741 controls were analyzed using Luminex xMAP technology and clinical data were retrieved from nationwide registers. Findings showed that children developing ASD were more likely to have decreased levels of both T helper-1(Th-1)-like cytokines (i.e. IFN-¿) and Th-2like cytokines (i.e. IL-4, IL-10) which may suggest a depressed or hypoactive immune cell activity during neonatal period in ASD.
Original languageEnglish
JournalJournal of Neuroimmunology
Volume252
Issue number1-2
Pages (from-to)75-82
Number of pages8
ISSN0165-5728
DOIs
Publication statusPublished - 2012

ID: 41851478