Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

Research output: Contribution to journalJournal articlepeer-review

Standard

Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice. / Sørensen, Gunnar; Jensen, Morten; Weikop, Pia; Nielsen, Ditte Dencker; Christiansen, Søren Hofman Oliveira; Løland, Claus Juul; Bengtsen, Cecilie Hee; Petersen, Jørgen Holm; Fink-Jensen, Anders; Wörtwein, Gitta; Woldbye, David Paul Drucker.

In: Psychopharmacology, Vol. 222, 02.2012, p. 565-577.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Sørensen, G, Jensen, M, Weikop, P, Nielsen, DD, Christiansen, SHO, Løland, CJ, Bengtsen, CH, Petersen, JH, Fink-Jensen, A, Wörtwein, G & Woldbye, DPD 2012, 'Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.', Psychopharmacology, vol. 222, pp. 565-577. https://doi.org/10.1007/s00213-012-2651-y

APA

Sørensen, G., Jensen, M., Weikop, P., Nielsen, D. D., Christiansen, S. H. O., Løland, C. J., Bengtsen, C. H., Petersen, J. H., Fink-Jensen, A., Wörtwein, G., & Woldbye, D. P. D. (2012). Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice. Psychopharmacology, 222, 565-577. https://doi.org/10.1007/s00213-012-2651-y

Vancouver

Sørensen G, Jensen M, Weikop P, Nielsen DD, Christiansen SHO, Løland CJ et al. Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice. Psychopharmacology. 2012 Feb;222:565-577. https://doi.org/10.1007/s00213-012-2651-y

Author

Sørensen, Gunnar ; Jensen, Morten ; Weikop, Pia ; Nielsen, Ditte Dencker ; Christiansen, Søren Hofman Oliveira ; Løland, Claus Juul ; Bengtsen, Cecilie Hee ; Petersen, Jørgen Holm ; Fink-Jensen, Anders ; Wörtwein, Gitta ; Woldbye, David Paul Drucker. / Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice. In: Psychopharmacology. 2012 ; Vol. 222. pp. 565-577.

Bibtex

@article{a0e2ea11a351457394c38103d11d1bee,
title = "Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.",
abstract = "Rationale Several studies suggest a role for neuropeptide Y (NPY) in addiction to drugs of abuse, including cocaine. However, the NPY receptors mediating addiction-related effects remain to be determined. Objectives To explore the potential role of Y5 NPY receptors in cocaine-induced behavioural effects. Methods The Y5 antagonist L-152,804 and Y5-knockout (Y5-KO) mice were tested in two models of cocaine addiction-related behaviour: acute self-administration and cocaine-induced hyperactivity. We also studied effects of Y5 receptor antagonism on cocaine-induced c-fos expression and extracellular dopamine with microdialysis as well as dopamine transporter-mediated uptake of dopamine in vitro. Immunocytochemistry was used to determine whether dopamine neurons express Y5-like immunoreactivity. Results In self-administration, L-152,804 prominently decreased nose-poking for the peak dose of cocaine and shifted the dose–response curve for cocaine downward. Y5-KO mice also showed modestly attenuated selfadministration. Cocaine-induced hyperactivity was attenuated by L-152,804 and in Y5-KO mice. Cocaine failed to increase c-fos expression in the nucleus accumbens and striatum of L-152,804-treated mice, indicating that the Y5 antagonist could act by influencing neural activity in these regions. Accordingly, the cocaine-induced increase in accumbal extracellular dopamine was attenuated by L- 152,804 and in Y5-KO mice, suggesting that Y5 antagonism influences cocaine-induced behaviour by regulating dopamine. Consistent with this concept, dopamine neurons in the ventral tegmental area appeared to contain Y5 receptors. In contrast, neither L-152,804 nor NPY influenced dopamine transporter-mediated dopamine uptake. Conclusions The present data indicate that Y5 antagonism may attenuate cocaine-induced behavioural effects, suggesting that Y5 receptors could be a potential therapeutic target in cocaine addiction.",
author = "Gunnar S{\o}rensen and Morten Jensen and Pia Weikop and Nielsen, {Ditte Dencker} and Christiansen, {S{\o}ren Hofman Oliveira} and L{\o}land, {Claus Juul} and Bengtsen, {Cecilie Hee} and Petersen, {J{\o}rgen Holm} and Anders Fink-Jensen and Gitta W{\"o}rtwein and Woldbye, {David Paul Drucker}",
year = "2012",
month = feb,
doi = "10.1007/s00213-012-2651-y",
language = "English",
volume = "222",
pages = "565--577",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

AU - Sørensen, Gunnar

AU - Jensen, Morten

AU - Weikop, Pia

AU - Nielsen, Ditte Dencker

AU - Christiansen, Søren Hofman Oliveira

AU - Løland, Claus Juul

AU - Bengtsen, Cecilie Hee

AU - Petersen, Jørgen Holm

AU - Fink-Jensen, Anders

AU - Wörtwein, Gitta

AU - Woldbye, David Paul Drucker

PY - 2012/2

Y1 - 2012/2

N2 - Rationale Several studies suggest a role for neuropeptide Y (NPY) in addiction to drugs of abuse, including cocaine. However, the NPY receptors mediating addiction-related effects remain to be determined. Objectives To explore the potential role of Y5 NPY receptors in cocaine-induced behavioural effects. Methods The Y5 antagonist L-152,804 and Y5-knockout (Y5-KO) mice were tested in two models of cocaine addiction-related behaviour: acute self-administration and cocaine-induced hyperactivity. We also studied effects of Y5 receptor antagonism on cocaine-induced c-fos expression and extracellular dopamine with microdialysis as well as dopamine transporter-mediated uptake of dopamine in vitro. Immunocytochemistry was used to determine whether dopamine neurons express Y5-like immunoreactivity. Results In self-administration, L-152,804 prominently decreased nose-poking for the peak dose of cocaine and shifted the dose–response curve for cocaine downward. Y5-KO mice also showed modestly attenuated selfadministration. Cocaine-induced hyperactivity was attenuated by L-152,804 and in Y5-KO mice. Cocaine failed to increase c-fos expression in the nucleus accumbens and striatum of L-152,804-treated mice, indicating that the Y5 antagonist could act by influencing neural activity in these regions. Accordingly, the cocaine-induced increase in accumbal extracellular dopamine was attenuated by L- 152,804 and in Y5-KO mice, suggesting that Y5 antagonism influences cocaine-induced behaviour by regulating dopamine. Consistent with this concept, dopamine neurons in the ventral tegmental area appeared to contain Y5 receptors. In contrast, neither L-152,804 nor NPY influenced dopamine transporter-mediated dopamine uptake. Conclusions The present data indicate that Y5 antagonism may attenuate cocaine-induced behavioural effects, suggesting that Y5 receptors could be a potential therapeutic target in cocaine addiction.

AB - Rationale Several studies suggest a role for neuropeptide Y (NPY) in addiction to drugs of abuse, including cocaine. However, the NPY receptors mediating addiction-related effects remain to be determined. Objectives To explore the potential role of Y5 NPY receptors in cocaine-induced behavioural effects. Methods The Y5 antagonist L-152,804 and Y5-knockout (Y5-KO) mice were tested in two models of cocaine addiction-related behaviour: acute self-administration and cocaine-induced hyperactivity. We also studied effects of Y5 receptor antagonism on cocaine-induced c-fos expression and extracellular dopamine with microdialysis as well as dopamine transporter-mediated uptake of dopamine in vitro. Immunocytochemistry was used to determine whether dopamine neurons express Y5-like immunoreactivity. Results In self-administration, L-152,804 prominently decreased nose-poking for the peak dose of cocaine and shifted the dose–response curve for cocaine downward. Y5-KO mice also showed modestly attenuated selfadministration. Cocaine-induced hyperactivity was attenuated by L-152,804 and in Y5-KO mice. Cocaine failed to increase c-fos expression in the nucleus accumbens and striatum of L-152,804-treated mice, indicating that the Y5 antagonist could act by influencing neural activity in these regions. Accordingly, the cocaine-induced increase in accumbal extracellular dopamine was attenuated by L- 152,804 and in Y5-KO mice, suggesting that Y5 antagonism influences cocaine-induced behaviour by regulating dopamine. Consistent with this concept, dopamine neurons in the ventral tegmental area appeared to contain Y5 receptors. In contrast, neither L-152,804 nor NPY influenced dopamine transporter-mediated dopamine uptake. Conclusions The present data indicate that Y5 antagonism may attenuate cocaine-induced behavioural effects, suggesting that Y5 receptors could be a potential therapeutic target in cocaine addiction.

U2 - 10.1007/s00213-012-2651-y

DO - 10.1007/s00213-012-2651-y

M3 - Journal article

C2 - 22367168

VL - 222

SP - 565

EP - 577

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

ER -

ID: 38468992