Oxidative DNA damage correlates with oxygen consumption in humans

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Oxidative DNA damage correlates with oxygen consumption in humans. / Loft, Steffen; Astrup, Arne; Buemann, Benjamin; Poulsen, Henrik Enghusen.

In: FASEB Journal, Vol. 8, No. 8, 1994, p. 534-537.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Loft, S, Astrup, A, Buemann, B & Poulsen, HE 1994, 'Oxidative DNA damage correlates with oxygen consumption in humans', FASEB Journal, vol. 8, no. 8, pp. 534-537.

APA

Loft, S., Astrup, A., Buemann, B., & Poulsen, H. E. (1994). Oxidative DNA damage correlates with oxygen consumption in humans. FASEB Journal, 8(8), 534-537.

Vancouver

Loft S, Astrup A, Buemann B, Poulsen HE. Oxidative DNA damage correlates with oxygen consumption in humans. FASEB Journal. 1994;8(8):534-537.

Author

Loft, Steffen ; Astrup, Arne ; Buemann, Benjamin ; Poulsen, Henrik Enghusen. / Oxidative DNA damage correlates with oxygen consumption in humans. In: FASEB Journal. 1994 ; Vol. 8, No. 8. pp. 534-537.

Bibtex

@article{8f47a2cd6f0742c1bfe72a6078595710,
title = "Oxidative DNA damage correlates with oxygen consumption in humans",
abstract = "Generation of reactive oxygen species from mitochondrial respiration has been proposed as an important determinant of longevity and cumulative cancer risk. Interspecies correlations and animal calorie restriction studies of metabolic rate and oxidative DNA damage support this notion. In the present study we have demonstrated a close association between oxidative DNA damage as assessed by the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and oxygen consumption in 33 healthy premenopausal women (r = 0.64; p = 0.00007). In the 12 women who smoked, 8-oxodG excretion was increased by 35{\%}, although oxygen consumption increased only 10{\%} compared with the 21 non- smoking women. Apparently, the rate of oxidative DNA damage relates to mitochondrial respiration in humans and is aggravated by smoking.",
keywords = "8-oxodG excretion, mitochondrial respiration, smoking",
author = "Steffen Loft and Arne Astrup and Benjamin Buemann and Poulsen, {Henrik Enghusen}",
year = "1994",
language = "English",
volume = "8",
pages = "534--537",
journal = "F A S E B Journal",
issn = "0892-6638",
publisher = "Federation of American Societies for Experimental Biology",
number = "8",

}

RIS

TY - JOUR

T1 - Oxidative DNA damage correlates with oxygen consumption in humans

AU - Loft, Steffen

AU - Astrup, Arne

AU - Buemann, Benjamin

AU - Poulsen, Henrik Enghusen

PY - 1994

Y1 - 1994

N2 - Generation of reactive oxygen species from mitochondrial respiration has been proposed as an important determinant of longevity and cumulative cancer risk. Interspecies correlations and animal calorie restriction studies of metabolic rate and oxidative DNA damage support this notion. In the present study we have demonstrated a close association between oxidative DNA damage as assessed by the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and oxygen consumption in 33 healthy premenopausal women (r = 0.64; p = 0.00007). In the 12 women who smoked, 8-oxodG excretion was increased by 35%, although oxygen consumption increased only 10% compared with the 21 non- smoking women. Apparently, the rate of oxidative DNA damage relates to mitochondrial respiration in humans and is aggravated by smoking.

AB - Generation of reactive oxygen species from mitochondrial respiration has been proposed as an important determinant of longevity and cumulative cancer risk. Interspecies correlations and animal calorie restriction studies of metabolic rate and oxidative DNA damage support this notion. In the present study we have demonstrated a close association between oxidative DNA damage as assessed by the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and oxygen consumption in 33 healthy premenopausal women (r = 0.64; p = 0.00007). In the 12 women who smoked, 8-oxodG excretion was increased by 35%, although oxygen consumption increased only 10% compared with the 21 non- smoking women. Apparently, the rate of oxidative DNA damage relates to mitochondrial respiration in humans and is aggravated by smoking.

KW - 8-oxodG excretion

KW - mitochondrial respiration

KW - smoking

UR - http://www.scopus.com/inward/record.url?scp=0028217660&partnerID=8YFLogxK

M3 - Journal article

C2 - 8181672

AN - SCOPUS:0028217660

VL - 8

SP - 534

EP - 537

JO - F A S E B Journal

JF - F A S E B Journal

SN - 0892-6638

IS - 8

ER -

ID: 209801635