Oxidative DNA damage correlates with oxygen consumption in humans
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Oxidative DNA damage correlates with oxygen consumption in humans. / Loft, Steffen; Astrup, Arne; Buemann, Benjamin; Poulsen, Henrik Enghusen.
In: FASEB Journal, Vol. 8, No. 8, 1994, p. 534-537.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Oxidative DNA damage correlates with oxygen consumption in humans
AU - Loft, Steffen
AU - Astrup, Arne
AU - Buemann, Benjamin
AU - Poulsen, Henrik Enghusen
PY - 1994
Y1 - 1994
N2 - Generation of reactive oxygen species from mitochondrial respiration has been proposed as an important determinant of longevity and cumulative cancer risk. Interspecies correlations and animal calorie restriction studies of metabolic rate and oxidative DNA damage support this notion. In the present study we have demonstrated a close association between oxidative DNA damage as assessed by the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and oxygen consumption in 33 healthy premenopausal women (r = 0.64; p = 0.00007). In the 12 women who smoked, 8-oxodG excretion was increased by 35%, although oxygen consumption increased only 10% compared with the 21 non- smoking women. Apparently, the rate of oxidative DNA damage relates to mitochondrial respiration in humans and is aggravated by smoking.
AB - Generation of reactive oxygen species from mitochondrial respiration has been proposed as an important determinant of longevity and cumulative cancer risk. Interspecies correlations and animal calorie restriction studies of metabolic rate and oxidative DNA damage support this notion. In the present study we have demonstrated a close association between oxidative DNA damage as assessed by the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and oxygen consumption in 33 healthy premenopausal women (r = 0.64; p = 0.00007). In the 12 women who smoked, 8-oxodG excretion was increased by 35%, although oxygen consumption increased only 10% compared with the 21 non- smoking women. Apparently, the rate of oxidative DNA damage relates to mitochondrial respiration in humans and is aggravated by smoking.
KW - 8-oxodG excretion
KW - mitochondrial respiration
KW - smoking
UR - http://www.scopus.com/inward/record.url?scp=0028217660&partnerID=8YFLogxK
M3 - Journal article
C2 - 8181672
AN - SCOPUS:0028217660
VL - 8
SP - 534
EP - 537
JO - F A S E B Journal
JF - F A S E B Journal
SN - 0892-6638
IS - 8
ER -
ID: 209801635