Personal exposure to ultrafine particles and oxidative DNA damage

Research output: Contribution to journalJournal articleResearchpeer-review

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Personal exposure to ultrafine particles and oxidative DNA damage. / Vinzents, Peter S; Møller, Peter; Sørensen, Mette; Knudsen, Lisbeth E; Hertel, Ole; Jensen, Finn Palmgren; Schibye, Bente; Loft, Steffen.

In: Environmental Health Perspectives, Vol. 113, No. 11, 2005, p. 1485-90.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Vinzents, PS, Møller, P, Sørensen, M, Knudsen, LE, Hertel, O, Jensen, FP, Schibye, B & Loft, S 2005, 'Personal exposure to ultrafine particles and oxidative DNA damage', Environmental Health Perspectives, vol. 113, no. 11, pp. 1485-90.

APA

Vinzents, P. S., Møller, P., Sørensen, M., Knudsen, L. E., Hertel, O., Jensen, F. P., ... Loft, S. (2005). Personal exposure to ultrafine particles and oxidative DNA damage. Environmental Health Perspectives, 113(11), 1485-90.

Vancouver

Vinzents PS, Møller P, Sørensen M, Knudsen LE, Hertel O, Jensen FP et al. Personal exposure to ultrafine particles and oxidative DNA damage. Environmental Health Perspectives. 2005;113(11):1485-90.

Author

Vinzents, Peter S ; Møller, Peter ; Sørensen, Mette ; Knudsen, Lisbeth E ; Hertel, Ole ; Jensen, Finn Palmgren ; Schibye, Bente ; Loft, Steffen. / Personal exposure to ultrafine particles and oxidative DNA damage. In: Environmental Health Perspectives. 2005 ; Vol. 113, No. 11. pp. 1485-90.

Bibtex

@article{8e939be0119211df803f000ea68e967b,
title = "Personal exposure to ultrafine particles and oxidative DNA damage",
abstract = "Exposure to ultrafine particles (UFPs) from vehicle exhaust has been related to risk of cardiovascular and pulmonary disease and cancer, even though exposure assessment is difficult. We studied personal exposure in terms of number concentrations of UFPs in the breathing zone, using portable instruments in six 18-hr periods in 15 healthy nonsmoking subjects. Exposure contrasts of outdoor pollution were achieved by bicycling in traffic for 5 days and in the laboratory for 1 day. Oxidative DNA damage was assessed as strand breaks and oxidized purines in mononuclear cells isolated from venous blood the morning after exposure measurement. Cumulated outdoor and cumulated indoor exposures to UFPs each were independent significant predictors of the level of purine oxidation in DNA but not of strand breaks. Ambient air concentrations of particulate matter with an aerodynamic diameter of < or = 10 microm (PM10), nitrous oxide, nitrogen dioxide, carbon monoxide, and/or number concentration of UFPs at urban background or busy street monitoring stations was not a significant predictor of DNA damage, although personal UFP exposure was correlated with urban background concentrations of CO and NO2, particularly during bicycling in traffic. The results indicate that biologic effects of UFPs occur at modest exposure, such as that occurring in traffic, which supports the relationship of UFPs and the adverse health effects of air pollution.",
author = "Vinzents, {Peter S} and Peter M{\o}ller and Mette S{\o}rensen and Knudsen, {Lisbeth E} and Ole Hertel and Jensen, {Finn Palmgren} and Bente Schibye and Steffen Loft",
note = "Keywords: Adult; Air Pollutants; Air Pollution, Indoor; Bicycling; Carbon Monoxide; Cookery; Cross-Over Studies; DNA Damage; Dust; Environmental Monitoring; Exercise; Female; Humans; Male; Nitrogen Oxides; Oxidative Stress; Particle Size; Vehicle Emissions",
year = "2005",
language = "English",
volume = "113",
pages = "1485--90",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "National Institute of Environmental Health Sciences",
number = "11",

}

RIS

TY - JOUR

T1 - Personal exposure to ultrafine particles and oxidative DNA damage

AU - Vinzents, Peter S

AU - Møller, Peter

AU - Sørensen, Mette

AU - Knudsen, Lisbeth E

AU - Hertel, Ole

AU - Jensen, Finn Palmgren

AU - Schibye, Bente

AU - Loft, Steffen

N1 - Keywords: Adult; Air Pollutants; Air Pollution, Indoor; Bicycling; Carbon Monoxide; Cookery; Cross-Over Studies; DNA Damage; Dust; Environmental Monitoring; Exercise; Female; Humans; Male; Nitrogen Oxides; Oxidative Stress; Particle Size; Vehicle Emissions

PY - 2005

Y1 - 2005

N2 - Exposure to ultrafine particles (UFPs) from vehicle exhaust has been related to risk of cardiovascular and pulmonary disease and cancer, even though exposure assessment is difficult. We studied personal exposure in terms of number concentrations of UFPs in the breathing zone, using portable instruments in six 18-hr periods in 15 healthy nonsmoking subjects. Exposure contrasts of outdoor pollution were achieved by bicycling in traffic for 5 days and in the laboratory for 1 day. Oxidative DNA damage was assessed as strand breaks and oxidized purines in mononuclear cells isolated from venous blood the morning after exposure measurement. Cumulated outdoor and cumulated indoor exposures to UFPs each were independent significant predictors of the level of purine oxidation in DNA but not of strand breaks. Ambient air concentrations of particulate matter with an aerodynamic diameter of < or = 10 microm (PM10), nitrous oxide, nitrogen dioxide, carbon monoxide, and/or number concentration of UFPs at urban background or busy street monitoring stations was not a significant predictor of DNA damage, although personal UFP exposure was correlated with urban background concentrations of CO and NO2, particularly during bicycling in traffic. The results indicate that biologic effects of UFPs occur at modest exposure, such as that occurring in traffic, which supports the relationship of UFPs and the adverse health effects of air pollution.

AB - Exposure to ultrafine particles (UFPs) from vehicle exhaust has been related to risk of cardiovascular and pulmonary disease and cancer, even though exposure assessment is difficult. We studied personal exposure in terms of number concentrations of UFPs in the breathing zone, using portable instruments in six 18-hr periods in 15 healthy nonsmoking subjects. Exposure contrasts of outdoor pollution were achieved by bicycling in traffic for 5 days and in the laboratory for 1 day. Oxidative DNA damage was assessed as strand breaks and oxidized purines in mononuclear cells isolated from venous blood the morning after exposure measurement. Cumulated outdoor and cumulated indoor exposures to UFPs each were independent significant predictors of the level of purine oxidation in DNA but not of strand breaks. Ambient air concentrations of particulate matter with an aerodynamic diameter of < or = 10 microm (PM10), nitrous oxide, nitrogen dioxide, carbon monoxide, and/or number concentration of UFPs at urban background or busy street monitoring stations was not a significant predictor of DNA damage, although personal UFP exposure was correlated with urban background concentrations of CO and NO2, particularly during bicycling in traffic. The results indicate that biologic effects of UFPs occur at modest exposure, such as that occurring in traffic, which supports the relationship of UFPs and the adverse health effects of air pollution.

M3 - Journal article

C2 - 16263500

VL - 113

SP - 1485

EP - 1490

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 11

ER -

ID: 17398001