PFAS concentrations in plasma samples from Danish school children and their mothers
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PFAS concentrations in plasma samples from Danish school children and their mothers. / Mørck, Thit Aarøe; Nielsen, Flemming; Nielsen, Jeanette Kolstrup Søgaard; Siersma, Volkert Dirk; Grandjean, Philippe; Knudsen, Lisbeth E.
In: Chemosphere, Vol. 129, 2015, p. 203-209.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - PFAS concentrations in plasma samples from Danish school children and their mothers
AU - Mørck, Thit Aarøe
AU - Nielsen, Flemming
AU - Nielsen, Jeanette Kolstrup Søgaard
AU - Siersma, Volkert Dirk
AU - Grandjean, Philippe
AU - Knudsen, Lisbeth E.
PY - 2015
Y1 - 2015
N2 - Perfluoroalkyl substances (PFASs) are accumulating in our environment and human exposure to these potentially harmful chemicals are of growing concern. In the present study, 116 children aged 6–11 and 143 mothers in two locations in Denmark donated blood samples as a supplement to their participation in the large European human biomonitoring project, DEMOCOPHES (Demonstration of a study to COordinate and Perform Human Biomonitoring on a European Scale). The blood samples were analyzed by LC-MS/MS for the concentration of six PFASs: PFOA, PFHxS, PFNA, PFDA, br-PFOS and n-PFOS. All measured compounds were above the detection limit in both mothers and children except for PFHxS in one child. There was a significant correlation between the levels in children and their mothers, indicating a family-related exposure pattern. However, we also found that the levels of PFOA, PFNA, PFDA, br-PFOS and total-PFOS were significantly higher in children compared to their mothers. This may be due to higher exposure in children through for example dust and soil, and due to the fact that children are smaller in body size and blood volume and hence have a lower storage capacity. Furthermore, we found an association between plasma levels and the age of the mothers and higher levels of plasma PFASs in mothers with low parity. There were no associations between PFAS concentrations and residential area, dietary habits of the participants or with respect to the birth order of the children. The levels are comparable to concentrations found in other Western countries.
AB - Perfluoroalkyl substances (PFASs) are accumulating in our environment and human exposure to these potentially harmful chemicals are of growing concern. In the present study, 116 children aged 6–11 and 143 mothers in two locations in Denmark donated blood samples as a supplement to their participation in the large European human biomonitoring project, DEMOCOPHES (Demonstration of a study to COordinate and Perform Human Biomonitoring on a European Scale). The blood samples were analyzed by LC-MS/MS for the concentration of six PFASs: PFOA, PFHxS, PFNA, PFDA, br-PFOS and n-PFOS. All measured compounds were above the detection limit in both mothers and children except for PFHxS in one child. There was a significant correlation between the levels in children and their mothers, indicating a family-related exposure pattern. However, we also found that the levels of PFOA, PFNA, PFDA, br-PFOS and total-PFOS were significantly higher in children compared to their mothers. This may be due to higher exposure in children through for example dust and soil, and due to the fact that children are smaller in body size and blood volume and hence have a lower storage capacity. Furthermore, we found an association between plasma levels and the age of the mothers and higher levels of plasma PFASs in mothers with low parity. There were no associations between PFAS concentrations and residential area, dietary habits of the participants or with respect to the birth order of the children. The levels are comparable to concentrations found in other Western countries.
KW - MOTHERS
KW - semrap-2014-2
U2 - 10.1016/j.chemosphere.2014.07.018
DO - 10.1016/j.chemosphere.2014.07.018
M3 - Journal article
C2 - 25147004
VL - 129
SP - 203
EP - 209
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
ER -
ID: 123735931