Placental perfusion - a human alternative
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Placental perfusion - a human alternative. / Mose, Tina; Knudsen, Lisbeth E.
In: ALTEX. Alternatives zu Tierexperimenten, Vol. 23 Suppl, 2006, p. 358-63.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Placental perfusion - a human alternative
AU - Mose, Tina
AU - Knudsen, Lisbeth E
PY - 2006
Y1 - 2006
N2 - Foetal exposures to environmental and medicinal products have impact on the growth of the foetus (e.g. cigarette smoke) and development of organs (e.g. methylmercury and Thalidomide). Perfusion studies of the human term placenta enable investigation of placental transport of chemical substances between the mother and foetus. Dual perfusion of a single cotyledon in the human placenta can contribute to a better understanding of the placental barrier, transport rate and mechanisms of different substances and placental metabolism. The perfusion system has recently been established in Copenhagen and represents a supplement and alternative to animal testing, bypassing the animal to human extrapolation. Placentas are readily obtainable from most births upon informed consent from the mothers and are considered a promising tissue alternative/supplement to animal experiments. The system is validated as a part of work package 2 of the integrated project ReProTect.
AB - Foetal exposures to environmental and medicinal products have impact on the growth of the foetus (e.g. cigarette smoke) and development of organs (e.g. methylmercury and Thalidomide). Perfusion studies of the human term placenta enable investigation of placental transport of chemical substances between the mother and foetus. Dual perfusion of a single cotyledon in the human placenta can contribute to a better understanding of the placental barrier, transport rate and mechanisms of different substances and placental metabolism. The perfusion system has recently been established in Copenhagen and represents a supplement and alternative to animal testing, bypassing the animal to human extrapolation. Placentas are readily obtainable from most births upon informed consent from the mothers and are considered a promising tissue alternative/supplement to animal experiments. The system is validated as a part of work package 2 of the integrated project ReProTect.
M3 - Journal article
C2 - 17492213
VL - 23 Suppl
SP - 358
EP - 363
JO - A L T E X. Alternatives to Animal Experimentation
JF - A L T E X. Alternatives to Animal Experimentation
SN - 1868-596X
ER -
ID: 17273240