Plasma alkylresorcinol concentrations, biomarkers of whole-grain wheat and rye intake, in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Plasma alkylresorcinol concentrations, biomarkers of whole-grain wheat and rye intake, in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. / Kyrø, Cecilie; Olsen, Anja; Bueno-de-Mesquita, H B As; Skeie, Guri; Loft, Steffen; Åman, Per; Leenders, Max; Dik, Vincent K; Siersema, Peter D; Pischon, Tobias; Christensen, Jane; Overvad, Kim; Boutron-Ruault, Marie-Christine; Fagherazzi, Guy; Cottet, Vanessa; Kühn, Tilman; Chang-Claude, Jenny; Boeing, Heiner; Trichopoulou, Antonia; Naska, Androniki; Oikonomidou, Despoina; Masala, Giovanna; Pala, Valeria; Tumino, Rosario; Vineis, Paolo; Mattiello, Amalia; Peeters, Petra H; Bakken, Toril; Weiderpass, Elisabete; Asli, Lene Angell; Sánchez, Soledad; Jakszyn, Paula; Sánchez, María-José; Amiano, Pilar; Huerta, José María; Barricarte, Aurelio; Ljuslinder, Ingrid; Palmqvist, Richard; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J; Travis, Ruth C; Slimani, Nadia; Freisling, Heinz; Ferrari, Pietro; Gunter, Marc J; Murphy, Neil; Riboli, Elio; Tjønneland, Anne; Landberg, Rikard.
In: The British Journal of Nutrition, Vol. 111, No. 10, 28.05.2014, p. 1881-90.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Plasma alkylresorcinol concentrations, biomarkers of whole-grain wheat and rye intake, in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
AU - Kyrø, Cecilie
AU - Olsen, Anja
AU - Bueno-de-Mesquita, H B As
AU - Skeie, Guri
AU - Loft, Steffen
AU - Åman, Per
AU - Leenders, Max
AU - Dik, Vincent K
AU - Siersema, Peter D
AU - Pischon, Tobias
AU - Christensen, Jane
AU - Overvad, Kim
AU - Boutron-Ruault, Marie-Christine
AU - Fagherazzi, Guy
AU - Cottet, Vanessa
AU - Kühn, Tilman
AU - Chang-Claude, Jenny
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Naska, Androniki
AU - Oikonomidou, Despoina
AU - Masala, Giovanna
AU - Pala, Valeria
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Mattiello, Amalia
AU - Peeters, Petra H
AU - Bakken, Toril
AU - Weiderpass, Elisabete
AU - Asli, Lene Angell
AU - Sánchez, Soledad
AU - Jakszyn, Paula
AU - Sánchez, María-José
AU - Amiano, Pilar
AU - Huerta, José María
AU - Barricarte, Aurelio
AU - Ljuslinder, Ingrid
AU - Palmqvist, Richard
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Key, Timothy J
AU - Travis, Ruth C
AU - Slimani, Nadia
AU - Freisling, Heinz
AU - Ferrari, Pietro
AU - Gunter, Marc J
AU - Murphy, Neil
AU - Riboli, Elio
AU - Tjønneland, Anne
AU - Landberg, Rikard
PY - 2014/5/28
Y1 - 2014/5/28
N2 - Whole-grain intake has been reported to be associated with a lower risk of several lifestyle-related diseases such as type 2 diabetes, CVD and some types of cancers. As measurement errors in self-reported whole-grain intake assessments can be substantial, dietary biomarkers are relevant to be used as complementary tools for dietary intake assessment. Alkylresorcinols (AR) are phenolic lipids found almost exclusively in whole-grain wheat and rye products among the commonly consumed foods and are considered as valid biomarkers of the intake of these products. In the present study, we analysed the plasma concentrations of five AR homologues in 2845 participants from ten European countries from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition. High concentrations of plasma total AR were found in participants from Scandinavia and Central Europe and lower concentrations in those from the Mediterranean countries. The geometric mean plasma total AR concentrations were between 35 and 41 nmol/l in samples drawn from fasting participants in the Central European and Scandinavian countries and below 23 nmol/l in those of participants from the Mediterranean countries. The whole-grain source (wheat or rye) could be determined using the ratio of two of the homologues. The main source was wheat in Greece, Italy, the Netherlands and the UK, whereas rye was also consumed in considerable amounts in Germany, Denmark and Sweden. The present study demonstrates a considerable variation in the plasma concentrations of total AR and concentrations of AR homologues across ten European countries, reflecting both quantitative and qualitative differences in the intake of whole-grain wheat and rye.
AB - Whole-grain intake has been reported to be associated with a lower risk of several lifestyle-related diseases such as type 2 diabetes, CVD and some types of cancers. As measurement errors in self-reported whole-grain intake assessments can be substantial, dietary biomarkers are relevant to be used as complementary tools for dietary intake assessment. Alkylresorcinols (AR) are phenolic lipids found almost exclusively in whole-grain wheat and rye products among the commonly consumed foods and are considered as valid biomarkers of the intake of these products. In the present study, we analysed the plasma concentrations of five AR homologues in 2845 participants from ten European countries from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition. High concentrations of plasma total AR were found in participants from Scandinavia and Central Europe and lower concentrations in those from the Mediterranean countries. The geometric mean plasma total AR concentrations were between 35 and 41 nmol/l in samples drawn from fasting participants in the Central European and Scandinavian countries and below 23 nmol/l in those of participants from the Mediterranean countries. The whole-grain source (wheat or rye) could be determined using the ratio of two of the homologues. The main source was wheat in Greece, Italy, the Netherlands and the UK, whereas rye was also consumed in considerable amounts in Germany, Denmark and Sweden. The present study demonstrates a considerable variation in the plasma concentrations of total AR and concentrations of AR homologues across ten European countries, reflecting both quantitative and qualitative differences in the intake of whole-grain wheat and rye.
KW - Aged
KW - Biological Markers
KW - Case-Control Studies
KW - Colorectal Neoplasms
KW - Diet
KW - Dietary Fiber
KW - Europe
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Resorcinols
KW - Secale cereale
KW - Triticum
U2 - 10.1017/S0007114513004388
DO - 10.1017/S0007114513004388
M3 - Journal article
C2 - 24521535
VL - 111
SP - 1881
EP - 1890
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 10
ER -
ID: 132418405