Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes

Research output: Contribution to journalJournal articleResearch

Standard

Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes. / Rajpert-De Meyts, Ewa; Jørgensen, N; Müller, Jørn; Skakkebaek, N E.

In: Journal of Pathology, Vol. 178, No. 2, 01.02.1996, p. 166-9.

Research output: Contribution to journalJournal articleResearch

Harvard

Rajpert-De Meyts, E, Jørgensen, N, Müller, J & Skakkebaek, NE 1996, 'Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes', Journal of Pathology, vol. 178, no. 2, pp. 166-9.

APA

Rajpert-De Meyts, E., Jørgensen, N., Müller, J., & Skakkebaek, N. E. (1996). Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes. Journal of Pathology, 178(2), 166-9.

Vancouver

Rajpert-De Meyts E, Jørgensen N, Müller J, Skakkebaek NE. Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes. Journal of Pathology. 1996 Feb 1;178(2):166-9.

Author

Rajpert-De Meyts, Ewa ; Jørgensen, N ; Müller, Jørn ; Skakkebaek, N E. / Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes. In: Journal of Pathology. 1996 ; Vol. 178, No. 2. pp. 166-9.

Bibtex

@article{a9ce9a54af5c4242afbf78edea598ebc,
title = "Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes",
abstract = "Stem cell factor (SCF) and its receptor Kit encoded by the c-kit proto-oncogene are crucial for the development and migration of primordial germ cells in rodents. The expression of Kit has been examined immunohistochemically in gonads obtained from five specimens of fetal tissues with intersex conditions which included 45,X/46,XY mosaicism; androgen insensitivity syndrome; and 46,XY/iso(p)Y mosaicism. Individuals with such disorders of sexual differentiation and Y-chromosome material carry a very high risk of developing testicular neoplasms. Fetal testicular germ cells of the intersex subjects expressed Kit at a later developmental age than controls, in which no Kit protein was detectable beyond the 15th week of gestation. This finding may indicate a disturbance of the chronology of germ cell development, or it may suggest a change of the regulation of c-kit expression in subjects with disorders of gonadal development.",
author = "{Rajpert-De Meyts}, Ewa and N J{\o}rgensen and J{\o}rn M{\"u}ller and Skakkebaek, {N E}",
year = "1996",
month = "2",
day = "1",
language = "English",
volume = "178",
pages = "166--9",
journal = "Journal of Pathology",
issn = "0022-3417",
publisher = "JohnWiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Prolonged expression of the c-kit receptor in germ cells of intersex fetal testes

AU - Rajpert-De Meyts, Ewa

AU - Jørgensen, N

AU - Müller, Jørn

AU - Skakkebaek, N E

PY - 1996/2/1

Y1 - 1996/2/1

N2 - Stem cell factor (SCF) and its receptor Kit encoded by the c-kit proto-oncogene are crucial for the development and migration of primordial germ cells in rodents. The expression of Kit has been examined immunohistochemically in gonads obtained from five specimens of fetal tissues with intersex conditions which included 45,X/46,XY mosaicism; androgen insensitivity syndrome; and 46,XY/iso(p)Y mosaicism. Individuals with such disorders of sexual differentiation and Y-chromosome material carry a very high risk of developing testicular neoplasms. Fetal testicular germ cells of the intersex subjects expressed Kit at a later developmental age than controls, in which no Kit protein was detectable beyond the 15th week of gestation. This finding may indicate a disturbance of the chronology of germ cell development, or it may suggest a change of the regulation of c-kit expression in subjects with disorders of gonadal development.

AB - Stem cell factor (SCF) and its receptor Kit encoded by the c-kit proto-oncogene are crucial for the development and migration of primordial germ cells in rodents. The expression of Kit has been examined immunohistochemically in gonads obtained from five specimens of fetal tissues with intersex conditions which included 45,X/46,XY mosaicism; androgen insensitivity syndrome; and 46,XY/iso(p)Y mosaicism. Individuals with such disorders of sexual differentiation and Y-chromosome material carry a very high risk of developing testicular neoplasms. Fetal testicular germ cells of the intersex subjects expressed Kit at a later developmental age than controls, in which no Kit protein was detectable beyond the 15th week of gestation. This finding may indicate a disturbance of the chronology of germ cell development, or it may suggest a change of the regulation of c-kit expression in subjects with disorders of gonadal development.

M3 - Journal article

VL - 178

SP - 166

EP - 169

JO - Journal of Pathology

JF - Journal of Pathology

SN - 0022-3417

IS - 2

ER -

ID: 34118319