Residential exposure to plasticizers and its possible role in the pathogenesis of asthma
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Residential exposure to plasticizers and its possible role in the pathogenesis of asthma. / Oie, L; Hersoug, Lars-Georg; Madsen, J O.
In: Environmental Health Perspectives, Vol. 105, No. 9, 09.1997, p. 972-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Residential exposure to plasticizers and its possible role in the pathogenesis of asthma
AU - Oie, L
AU - Hersoug, Lars-Georg
AU - Madsen, J O
PY - 1997/9
Y1 - 1997/9
N2 - The plasticizer di(2-ethylhexyl) phthalate (DEHP) is widely used in building materials. DEHP is identified as the major plasticizer exposure in dwellings. We provide evidence that inhalation exposure to DEHP as aerosols adsorbed to particulate matter is as important, or more important, than vapor phase exposure. The particulate inhalation exposure to DEHP is considered to be significant due to its low clearance and extensive penetration into the pulmonary region. DEHP is capable of creating high local concentrations in the airways at the deposition site with subsequent local effects. The proposed mechanism of effect states that mono(2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD(2), 9alpha,11betaPGF2, and PGF2alpha, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.
AB - The plasticizer di(2-ethylhexyl) phthalate (DEHP) is widely used in building materials. DEHP is identified as the major plasticizer exposure in dwellings. We provide evidence that inhalation exposure to DEHP as aerosols adsorbed to particulate matter is as important, or more important, than vapor phase exposure. The particulate inhalation exposure to DEHP is considered to be significant due to its low clearance and extensive penetration into the pulmonary region. DEHP is capable of creating high local concentrations in the airways at the deposition site with subsequent local effects. The proposed mechanism of effect states that mono(2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD(2), 9alpha,11betaPGF2, and PGF2alpha, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.
KW - Aerosols
KW - Air Pollution, Indoor
KW - Asthma
KW - Child
KW - Child, Preschool
KW - Diethylhexyl Phthalate
KW - Environmental Exposure
KW - Female
KW - Housing
KW - Humans
KW - Inflammation
KW - Inhalation Exposure
KW - Male
M3 - Journal article
C2 - 9374082
VL - 105
SP - 972
EP - 978
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 9
ER -
ID: 45422620