Risk of metabolic disorders in childless men: a population-based cohort study
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Risk of metabolic disorders in childless men : a population-based cohort study. / Bungum, Ane Berger; Glazer, Clara Helene; Bonde, Jens Peter; Nilsson, Peter M; Giwercman, Aleksander; Søgaard Tøttenborg, Sandra.
In: BMJ Open, Vol. 8, No. 8, e020293, 2018, p. 1-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Risk of metabolic disorders in childless men
T2 - a population-based cohort study
AU - Bungum, Ane Berger
AU - Glazer, Clara Helene
AU - Bonde, Jens Peter
AU - Nilsson, Peter M
AU - Giwercman, Aleksander
AU - Søgaard Tøttenborg, Sandra
N1 - © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ.
PY - 2018
Y1 - 2018
N2 - OBJECTIVE: To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes.DESIGN: A population-based cohort study.SETTING: Not applicable.PARTICIPANTS: 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort.INTERVENTIONS: None.MAIN OUTCOME MEASURES: From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men.RESULTS: At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)).CONCLUSION: This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.
AB - OBJECTIVE: To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes.DESIGN: A population-based cohort study.SETTING: Not applicable.PARTICIPANTS: 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort.INTERVENTIONS: None.MAIN OUTCOME MEASURES: From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men.RESULTS: At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)).CONCLUSION: This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.
U2 - 10.1136/bmjopen-2017-020293
DO - 10.1136/bmjopen-2017-020293
M3 - Journal article
C2 - 30121591
VL - 8
SP - 1
EP - 7
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 8
M1 - e020293
ER -
ID: 222163723