Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty

Research output: Contribution to journalJournal articleResearchpeer-review

A Juul, Allan Flyvbjerg, Jan Frystyk, J Müller, N E Skakkebaek

Circulating IGF-I and IGF binding protein-3 (IGFBP-3) levels both increase in puberty where growth velocity is high. The amount of free IGF-I is dependent on the IGF-I level and on the concentrations of the specific IGFBPs. Furthermore, IGFBP-3 proteolysis regulates the bioavailability of IGF-I. However, the concentration of free IGF-I and possible IGFBP-3 proteolytic activity in puberty has not previously been studied.
Original languageEnglish
JournalClinical Endocrinology
Volume44
Issue number5
Pages (from-to)515-23
Number of pages9
ISSN0300-0664
Publication statusPublished - 1996

ID: 48486539