Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia. / Fabricius, Katrine; Steiniger-Brach, Björn; Helboe, Lone; Fink-Jensen, Anders; Wörtwein, Gitta.
In: International Journal of Developmental Neuroscience, Vol. 29, No. 3, 2011, p. 347-50.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia
AU - Fabricius, Katrine
AU - Steiniger-Brach, Björn
AU - Helboe, Lone
AU - Fink-Jensen, Anders
AU - Wörtwein, Gitta
N1 - Copyright © 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Post-weaning social isolation of rats produces an array of behavioral and neurochemical changes indicative of altered dopamine function. It has therefore been suggested that post-weaning social isolation mimics some aspects of schizophrenia. Here we replicate and extent these findings to include an investigation of prefrontal cortical dopamine dynamics using in vivo microdialysis. Social isolation for 12 weeks after weaning caused increased locomotor activity in response to novelty and amphetamine challenge. In vivo microdialysis experiments revealed that while social isolation did not change basal dopamine levels in the nucleus accumbens, it did cause a significant reduction of basal dopamine release in the prefrontal cortex. In addition, social isolation lead to a significantly larger dopamine response to an amphetamine challenge, in both the nucleus accumbens and the prefrontal cortex compared to group housed controls. Taken together, these results indicate that post-weaning social isolation alters dopaminergic function with changes resembling subcortical hyperdopaminergia and prefrontal hypodopaminergia similar to what has been observed in schizophrenic patients.
AB - Post-weaning social isolation of rats produces an array of behavioral and neurochemical changes indicative of altered dopamine function. It has therefore been suggested that post-weaning social isolation mimics some aspects of schizophrenia. Here we replicate and extent these findings to include an investigation of prefrontal cortical dopamine dynamics using in vivo microdialysis. Social isolation for 12 weeks after weaning caused increased locomotor activity in response to novelty and amphetamine challenge. In vivo microdialysis experiments revealed that while social isolation did not change basal dopamine levels in the nucleus accumbens, it did cause a significant reduction of basal dopamine release in the prefrontal cortex. In addition, social isolation lead to a significantly larger dopamine response to an amphetamine challenge, in both the nucleus accumbens and the prefrontal cortex compared to group housed controls. Taken together, these results indicate that post-weaning social isolation alters dopaminergic function with changes resembling subcortical hyperdopaminergia and prefrontal hypodopaminergia similar to what has been observed in schizophrenic patients.
KW - Amphetamine
KW - Animals
KW - Behavior, Animal
KW - Dopamine
KW - Dopamine Agents
KW - Homeostasis
KW - Microdialysis
KW - Motor Activity
KW - Nucleus Accumbens
KW - Prefrontal Cortex
KW - Rats
KW - Schizophrenia
KW - Social Behavior
KW - Social Isolation
U2 - 10.1016/j.ijdevneu.2010.09.003
DO - 10.1016/j.ijdevneu.2010.09.003
M3 - Journal article
C2 - 20884342
VL - 29
SP - 347
EP - 350
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
SN - 0736-5748
IS - 3
ER -
ID: 37581588