Symptom profiles and executive function in childhood obsessive-compulsive disorder

Research output: Contribution to journalJournal articlepeer-review

Standard

Symptom profiles and executive function in childhood obsessive-compulsive disorder. / Hybel, Katja Anna; Lykke Mortensen, Erik; Højgaard, David R. M. A.; Lambek, Rikke; Hove Thomsen, Per.

In: Journal of Obsessive-Compulsive and Related Disorders, Vol. 14, 07.2017, p. 36-46.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Hybel, KA, Lykke Mortensen, E, Højgaard, DRMA, Lambek, R & Hove Thomsen, P 2017, 'Symptom profiles and executive function in childhood obsessive-compulsive disorder', Journal of Obsessive-Compulsive and Related Disorders, vol. 14, pp. 36-46. https://doi.org/10.1016/j.jocrd.2017.05.003

APA

Hybel, K. A., Lykke Mortensen, E., Højgaard, D. R. M. A., Lambek, R., & Hove Thomsen, P. (2017). Symptom profiles and executive function in childhood obsessive-compulsive disorder. Journal of Obsessive-Compulsive and Related Disorders, 14, 36-46. https://doi.org/10.1016/j.jocrd.2017.05.003

Vancouver

Hybel KA, Lykke Mortensen E, Højgaard DRMA, Lambek R, Hove Thomsen P. Symptom profiles and executive function in childhood obsessive-compulsive disorder. Journal of Obsessive-Compulsive and Related Disorders. 2017 Jul;14:36-46. https://doi.org/10.1016/j.jocrd.2017.05.003

Author

Hybel, Katja Anna ; Lykke Mortensen, Erik ; Højgaard, David R. M. A. ; Lambek, Rikke ; Hove Thomsen, Per. / Symptom profiles and executive function in childhood obsessive-compulsive disorder. In: Journal of Obsessive-Compulsive and Related Disorders. 2017 ; Vol. 14. pp. 36-46.

Bibtex

@article{98c9dfdc610f4cfda8386f91d43f3a27,
title = "Symptom profiles and executive function in childhood obsessive-compulsive disorder",
abstract = "Obsessive-compulsive disorder (OCD) often becomes manifest in childhood. It has been suggested that the symptom heterogeneity of the disorder could mask subgroups associated with executive function (EF) impairment. Though supported in adult studies, this is scarcely investigated in children. The aims of the present study were to: (i) investigate OCD symptom subgroups using an empirically supported and age-appropriate definition of symptom dimensions (SD) as well as latent profile analysis (LPA); (ii) compare the identified subgroups with respect to EFs, demographic, and clinical descriptives; and (iii) explore the associations between SDs and EFs. The study included 50 pediatric OCD patients and 50 matched controls. Patients were assessed with the Children's Yale-Brown Obsessive-Compulsive Scale from which three SD factor scores were generated. Participants were assessed with EF tasks from which latent variables measuring working memory, set shifting and response inhibition were derived. Parents rated executive function behaviors in their children. Three subgroups were identified, each predominantly characterized by one of the SDs. Subgroups differed with respect to parent-rated working memory and several demographic and basic clinical characteristics. The findings suggest the presence of clinically relevant child and adolescent OCD SD subgroups, but do not support the relevance of EFs in distinguishing SDs.",
keywords = "Children, Executive function, Latent profile analysis, Obsessive-compulsive disorder, Symptom dimension subgroups",
author = "Hybel, {Katja Anna} and {Lykke Mortensen}, Erik and H{\o}jgaard, {David R. M. A.} and Rikke Lambek and {Hove Thomsen}, Per",
year = "2017",
month = jul,
doi = "10.1016/j.jocrd.2017.05.003",
language = "English",
volume = "14",
pages = "36--46",
journal = "Journal of Obsessive-Compulsive and Related Disorders",
issn = "2211-3649",
publisher = "Elsevier Science & Technology",

}

RIS

TY - JOUR

T1 - Symptom profiles and executive function in childhood obsessive-compulsive disorder

AU - Hybel, Katja Anna

AU - Lykke Mortensen, Erik

AU - Højgaard, David R. M. A.

AU - Lambek, Rikke

AU - Hove Thomsen, Per

PY - 2017/7

Y1 - 2017/7

N2 - Obsessive-compulsive disorder (OCD) often becomes manifest in childhood. It has been suggested that the symptom heterogeneity of the disorder could mask subgroups associated with executive function (EF) impairment. Though supported in adult studies, this is scarcely investigated in children. The aims of the present study were to: (i) investigate OCD symptom subgroups using an empirically supported and age-appropriate definition of symptom dimensions (SD) as well as latent profile analysis (LPA); (ii) compare the identified subgroups with respect to EFs, demographic, and clinical descriptives; and (iii) explore the associations between SDs and EFs. The study included 50 pediatric OCD patients and 50 matched controls. Patients were assessed with the Children's Yale-Brown Obsessive-Compulsive Scale from which three SD factor scores were generated. Participants were assessed with EF tasks from which latent variables measuring working memory, set shifting and response inhibition were derived. Parents rated executive function behaviors in their children. Three subgroups were identified, each predominantly characterized by one of the SDs. Subgroups differed with respect to parent-rated working memory and several demographic and basic clinical characteristics. The findings suggest the presence of clinically relevant child and adolescent OCD SD subgroups, but do not support the relevance of EFs in distinguishing SDs.

AB - Obsessive-compulsive disorder (OCD) often becomes manifest in childhood. It has been suggested that the symptom heterogeneity of the disorder could mask subgroups associated with executive function (EF) impairment. Though supported in adult studies, this is scarcely investigated in children. The aims of the present study were to: (i) investigate OCD symptom subgroups using an empirically supported and age-appropriate definition of symptom dimensions (SD) as well as latent profile analysis (LPA); (ii) compare the identified subgroups with respect to EFs, demographic, and clinical descriptives; and (iii) explore the associations between SDs and EFs. The study included 50 pediatric OCD patients and 50 matched controls. Patients were assessed with the Children's Yale-Brown Obsessive-Compulsive Scale from which three SD factor scores were generated. Participants were assessed with EF tasks from which latent variables measuring working memory, set shifting and response inhibition were derived. Parents rated executive function behaviors in their children. Three subgroups were identified, each predominantly characterized by one of the SDs. Subgroups differed with respect to parent-rated working memory and several demographic and basic clinical characteristics. The findings suggest the presence of clinically relevant child and adolescent OCD SD subgroups, but do not support the relevance of EFs in distinguishing SDs.

KW - Children

KW - Executive function

KW - Latent profile analysis

KW - Obsessive-compulsive disorder

KW - Symptom dimension subgroups

U2 - 10.1016/j.jocrd.2017.05.003

DO - 10.1016/j.jocrd.2017.05.003

M3 - Journal article

AN - SCOPUS:85019188057

VL - 14

SP - 36

EP - 46

JO - Journal of Obsessive-Compulsive and Related Disorders

JF - Journal of Obsessive-Compulsive and Related Disorders

SN - 2211-3649

ER -

ID: 196914081