Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy. / Harnung Scholten, Rebecca; Møller, Peter; Jovanovic Andersen, Zorana; Dehlendorff, Christian; Khan, Jibran; Brandt, Jørgen; Ketzel, Matthias; Knudsen, Lisbeth E.; Mathiesen, Line.

In: Environment International, Vol. 146, 106202, 2021.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Harnung Scholten, R, Møller, P, Jovanovic Andersen, Z, Dehlendorff, C, Khan, J, Brandt, J, Ketzel, M, Knudsen, LE & Mathiesen, L 2021, 'Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy', Environment International, vol. 146, 106202. https://doi.org/10.1016/j.envint.2020.106202

APA

Harnung Scholten, R., Møller, P., Jovanovic Andersen, Z., Dehlendorff, C., Khan, J., Brandt, J., Ketzel, M., Knudsen, L. E., & Mathiesen, L. (2021). Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy. Environment International, 146, [106202]. https://doi.org/10.1016/j.envint.2020.106202

Vancouver

Harnung Scholten R, Møller P, Jovanovic Andersen Z, Dehlendorff C, Khan J, Brandt J et al. Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy. Environment International. 2021;146. 106202. https://doi.org/10.1016/j.envint.2020.106202

Author

Harnung Scholten, Rebecca ; Møller, Peter ; Jovanovic Andersen, Zorana ; Dehlendorff, Christian ; Khan, Jibran ; Brandt, Jørgen ; Ketzel, Matthias ; Knudsen, Lisbeth E. ; Mathiesen, Line. / Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy. In: Environment International. 2021 ; Vol. 146.

Bibtex

@article{5665d554bfca483b8e69dc8b83baa97b,
title = "Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy",
abstract = "Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to air pollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL in maternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately after birth in 296 Danish mother-child pairs from a birth cohort. Exposure data was obtained using the high-resolution and spatial–temporal air pollution modeling system DEHM-UBM-AirGIS for PM2.5, PM10, SO2, NH4+, black carbon (BC), organic carbon (OC), CO, O3, NO2, and NOx at residential and occupational addresses of the participating women for the full duration of the pregnancy. The association between prenatal exposure to air pollutants and TL was investigated using distributed lag models. There were significant and positive associations between TL in umbilical cord blood cells and prenatal exposure to BC, OC, NO2, NOx, CO, and O3 during the second trimester. TL in umbilical cord blood was significantly and inversely associated with prenatal exposure to PM2.5, BC, OC, SO2, NH4+, CO and NO2 during the third trimester. There were similar inverse associations between TL from umbilical cord blood cells and air pollution exposure at the residential and occupational addresses. There were weaker or no associations between air pollution exposure and TL in placenta tissue and maternal blood cells. In conclusion, both the second and third trimesters of pregnancy are shown to be sensitive windows of exposure to air pollution affecting fetal TL.",
keywords = "Air pollution exposure, Biological aging, In utero life, Leukocyte telomere length, Life expectancy, Prenatal exposure",
author = "{Harnung Scholten}, Rebecca and Peter M{\o}ller and {Jovanovic Andersen}, Zorana and Christian Dehlendorff and Jibran Khan and J{\o}rgen Brandt and Matthias Ketzel and Knudsen, {Lisbeth E.} and Line Mathiesen",
year = "2021",
doi = "10.1016/j.envint.2020.106202",
language = "English",
volume = "146",
journal = "Environment International",
issn = "0160-4120",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Telomere length in newborns is associated with exposure to low levels of air pollution during pregnancy

AU - Harnung Scholten, Rebecca

AU - Møller, Peter

AU - Jovanovic Andersen, Zorana

AU - Dehlendorff, Christian

AU - Khan, Jibran

AU - Brandt, Jørgen

AU - Ketzel, Matthias

AU - Knudsen, Lisbeth E.

AU - Mathiesen, Line

PY - 2021

Y1 - 2021

N2 - Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to air pollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL in maternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately after birth in 296 Danish mother-child pairs from a birth cohort. Exposure data was obtained using the high-resolution and spatial–temporal air pollution modeling system DEHM-UBM-AirGIS for PM2.5, PM10, SO2, NH4+, black carbon (BC), organic carbon (OC), CO, O3, NO2, and NOx at residential and occupational addresses of the participating women for the full duration of the pregnancy. The association between prenatal exposure to air pollutants and TL was investigated using distributed lag models. There were significant and positive associations between TL in umbilical cord blood cells and prenatal exposure to BC, OC, NO2, NOx, CO, and O3 during the second trimester. TL in umbilical cord blood was significantly and inversely associated with prenatal exposure to PM2.5, BC, OC, SO2, NH4+, CO and NO2 during the third trimester. There were similar inverse associations between TL from umbilical cord blood cells and air pollution exposure at the residential and occupational addresses. There were weaker or no associations between air pollution exposure and TL in placenta tissue and maternal blood cells. In conclusion, both the second and third trimesters of pregnancy are shown to be sensitive windows of exposure to air pollution affecting fetal TL.

AB - Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to air pollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL in maternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately after birth in 296 Danish mother-child pairs from a birth cohort. Exposure data was obtained using the high-resolution and spatial–temporal air pollution modeling system DEHM-UBM-AirGIS for PM2.5, PM10, SO2, NH4+, black carbon (BC), organic carbon (OC), CO, O3, NO2, and NOx at residential and occupational addresses of the participating women for the full duration of the pregnancy. The association between prenatal exposure to air pollutants and TL was investigated using distributed lag models. There were significant and positive associations between TL in umbilical cord blood cells and prenatal exposure to BC, OC, NO2, NOx, CO, and O3 during the second trimester. TL in umbilical cord blood was significantly and inversely associated with prenatal exposure to PM2.5, BC, OC, SO2, NH4+, CO and NO2 during the third trimester. There were similar inverse associations between TL from umbilical cord blood cells and air pollution exposure at the residential and occupational addresses. There were weaker or no associations between air pollution exposure and TL in placenta tissue and maternal blood cells. In conclusion, both the second and third trimesters of pregnancy are shown to be sensitive windows of exposure to air pollution affecting fetal TL.

KW - Air pollution exposure

KW - Biological aging

KW - In utero life

KW - Leukocyte telomere length

KW - Life expectancy

KW - Prenatal exposure

U2 - 10.1016/j.envint.2020.106202

DO - 10.1016/j.envint.2020.106202

M3 - Journal article

C2 - 33120230

AN - SCOPUS:85094116123

VL - 146

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 106202

ER -

ID: 255207651