Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations

Research output: Contribution to journalReview

Standard

Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. / Skakkebaek, N E; Rajpert-De Meyts, E; Jørgensen, N; Main, K M; Leffers, H; Andersson, A-M; Juul, A; Jensen, T K; Toppari, J.

In: International Journal of Andrology, Vol. 30, No. 4, 2007, p. 198-204; discussion 204-5.

Research output: Contribution to journalReview

Harvard

Skakkebaek, NE, Rajpert-De Meyts, E, Jørgensen, N, Main, KM, Leffers, H, Andersson, A-M, Juul, A, Jensen, TK & Toppari, J 2007, 'Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations', International Journal of Andrology, vol. 30, no. 4, pp. 198-204; discussion 204-5. https://doi.org/10.1111/j.1365-2605.2007.00776.x

APA

Skakkebaek, N. E., Rajpert-De Meyts, E., Jørgensen, N., Main, K. M., Leffers, H., Andersson, A-M., Juul, A., Jensen, T. K., & Toppari, J. (2007). Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. International Journal of Andrology, 30(4), 198-204; discussion 204-5. https://doi.org/10.1111/j.1365-2605.2007.00776.x

Vancouver

Skakkebaek NE, Rajpert-De Meyts E, Jørgensen N, Main KM, Leffers H, Andersson A-M et al. Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. International Journal of Andrology. 2007;30(4):198-204; discussion 204-5. https://doi.org/10.1111/j.1365-2605.2007.00776.x

Author

Skakkebaek, N E ; Rajpert-De Meyts, E ; Jørgensen, N ; Main, K M ; Leffers, H ; Andersson, A-M ; Juul, A ; Jensen, T K ; Toppari, J. / Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. In: International Journal of Andrology. 2007 ; Vol. 30, No. 4. pp. 198-204; discussion 204-5.

Bibtex

@article{15d20c89b6064a28875f7910161a3c36,
title = "Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations",
abstract = "Recently a worldwide rise in the incidence of testicular germ cell cancer (TGCC) has been repeatedly reported. The changing disease pattern may signal that other testicular problems may also be increasing. We have reviewed recent research progress, in particular evidence gathered in the Nordic countries, which shows strong associations between testicular cancer, undescended testis, hypospadias, poor testicular development and function, and male infertility. These studies have led us to suggest the existence of a testicular dysgenesis syndrome (TDS), of which TGCC, undescended testis, hypospadias/disorders of sex differentiation and male fertility problems may be symptoms with varying penetration. In spite of their fetal origin, most of the TDS symptoms, including TGCC and poor semen quality, can only be diagnosed in adulthood. Data from a Danish-Finnish research collaboration strongly suggest that trends in TGCC rates of a population may be 'whistle blowers' of other reproductive health problems. As cancer registries are often of excellent quality - in contrast to registries for congenital abnormalities - health authorities should consider an increase in TGCC as a warning that other reproductive health problems may also be rising.",
author = "Skakkebaek, {N E} and {Rajpert-De Meyts}, E and N J{\o}rgensen and Main, {K M} and H Leffers and A-M Andersson and A Juul and Jensen, {T K} and J Toppari",
year = "2007",
doi = "http://dx.doi.org/10.1111/j.1365-2605.2007.00776.x",
language = "English",
volume = "30",
pages = "198--204; discussion 204--5",
journal = "International Journal of Andrology",
issn = "0105-6263",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations

AU - Skakkebaek, N E

AU - Rajpert-De Meyts, E

AU - Jørgensen, N

AU - Main, K M

AU - Leffers, H

AU - Andersson, A-M

AU - Juul, A

AU - Jensen, T K

AU - Toppari, J

PY - 2007

Y1 - 2007

N2 - Recently a worldwide rise in the incidence of testicular germ cell cancer (TGCC) has been repeatedly reported. The changing disease pattern may signal that other testicular problems may also be increasing. We have reviewed recent research progress, in particular evidence gathered in the Nordic countries, which shows strong associations between testicular cancer, undescended testis, hypospadias, poor testicular development and function, and male infertility. These studies have led us to suggest the existence of a testicular dysgenesis syndrome (TDS), of which TGCC, undescended testis, hypospadias/disorders of sex differentiation and male fertility problems may be symptoms with varying penetration. In spite of their fetal origin, most of the TDS symptoms, including TGCC and poor semen quality, can only be diagnosed in adulthood. Data from a Danish-Finnish research collaboration strongly suggest that trends in TGCC rates of a population may be 'whistle blowers' of other reproductive health problems. As cancer registries are often of excellent quality - in contrast to registries for congenital abnormalities - health authorities should consider an increase in TGCC as a warning that other reproductive health problems may also be rising.

AB - Recently a worldwide rise in the incidence of testicular germ cell cancer (TGCC) has been repeatedly reported. The changing disease pattern may signal that other testicular problems may also be increasing. We have reviewed recent research progress, in particular evidence gathered in the Nordic countries, which shows strong associations between testicular cancer, undescended testis, hypospadias, poor testicular development and function, and male infertility. These studies have led us to suggest the existence of a testicular dysgenesis syndrome (TDS), of which TGCC, undescended testis, hypospadias/disorders of sex differentiation and male fertility problems may be symptoms with varying penetration. In spite of their fetal origin, most of the TDS symptoms, including TGCC and poor semen quality, can only be diagnosed in adulthood. Data from a Danish-Finnish research collaboration strongly suggest that trends in TGCC rates of a population may be 'whistle blowers' of other reproductive health problems. As cancer registries are often of excellent quality - in contrast to registries for congenital abnormalities - health authorities should consider an increase in TGCC as a warning that other reproductive health problems may also be rising.

U2 - http://dx.doi.org/10.1111/j.1365-2605.2007.00776.x

DO - http://dx.doi.org/10.1111/j.1365-2605.2007.00776.x

M3 - Review

VL - 30

SP - 198-204; discussion 204-5

JO - International Journal of Andrology

JF - International Journal of Andrology

SN - 0105-6263

IS - 4

ER -

ID: 48484007