The impact of gender and puberty on reference values for urinary growth hormone excretion: a study of 3 morning urine samples in 517 healthy children and adults

Research output: Contribution to journalJournal articlepeer-review

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The impact of gender and puberty on reference values for urinary growth hormone excretion : a study of 3 morning urine samples in 517 healthy children and adults. / Main, K M; Jarden, M; Angelo, L; Dinesen, Birthe Irene; Hertel, Niels; Juul, A; Müller, J; Skakkebaek, N E.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 79, No. 3, 1994, p. 865-71.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Main, KM, Jarden, M, Angelo, L, Dinesen, BI, Hertel, N, Juul, A, Müller, J & Skakkebaek, NE 1994, 'The impact of gender and puberty on reference values for urinary growth hormone excretion: a study of 3 morning urine samples in 517 healthy children and adults', Journal of Clinical Endocrinology and Metabolism, vol. 79, no. 3, pp. 865-71.

APA

Main, K. M., Jarden, M., Angelo, L., Dinesen, B. I., Hertel, N., Juul, A., Müller, J., & Skakkebaek, N. E. (1994). The impact of gender and puberty on reference values for urinary growth hormone excretion: a study of 3 morning urine samples in 517 healthy children and adults. Journal of Clinical Endocrinology and Metabolism, 79(3), 865-71.

Vancouver

Main KM, Jarden M, Angelo L, Dinesen BI, Hertel N, Juul A et al. The impact of gender and puberty on reference values for urinary growth hormone excretion: a study of 3 morning urine samples in 517 healthy children and adults. Journal of Clinical Endocrinology and Metabolism. 1994;79(3):865-71.

Author

Main, K M ; Jarden, M ; Angelo, L ; Dinesen, Birthe Irene ; Hertel, Niels ; Juul, A ; Müller, J ; Skakkebaek, N E. / The impact of gender and puberty on reference values for urinary growth hormone excretion : a study of 3 morning urine samples in 517 healthy children and adults. In: Journal of Clinical Endocrinology and Metabolism. 1994 ; Vol. 79, No. 3. pp. 865-71.

Bibtex

@article{bf2fbc0155144042af311e9a4df45679,
title = "The impact of gender and puberty on reference values for urinary growth hormone excretion: a study of 3 morning urine samples in 517 healthy children and adults",
abstract = "Some recent studies have indicated that measurement of urinary GH (U-GH) excretion may be a useful tool for the evaluation of GH insufficiency in children with growth disorders, although some investigators are skeptical about the diagnostic value of U-GH. Most current assays are only available for specific laboratories or require time-intensive pretreatments of the specimens. This limits the possibility for many centers to compare their patients' data with others or to establish their own reference ranges for U-GH excretion. Therefore, we investigated the performance of a commercially available kit, which allows direct measurement of U-GH in untreated urine specimens. We established a reference range for the geometric mean of 3 morning urine samples in 446 healthy children and 71 adults. U-GH could be determined in all but 9 of 1526 samples (99.4%). U-GH excretion was significantly dependent on pubertal maturation (P <0.001) and sex (P <0.001), whereas age had no significant influence in the prepubertal group (P > 0.3). Peak values occurred in Tanner stages 3 and 4 (369 and 391 pg/h in females; 503 and 882 pg/h in males), corresponding to an age interval of 11-18 yr in boys and 9-15 yr in girls. Short collection periods (<6 h) were related to low values for U-GH excretion (nanograms per night; P <0.02). This time effect disappeared if U-GH excretion was expressed as picograms per h. If U-GH was related to creatinine output, there was a decrease in U-GH excretion during prepuberty, a blunting of the pubertal peak, and lower values in adults than in prepubertal children (P <0.0002). The intraindividual variation in U-GH excretion (picograms per h) ranged from 40-61%, constituting approximately two thirds of the interindividual variation. This variation was not lowered by relating U-GH to creatinine. We conclude that the assay was suitable for measurement of U-GH excretion in virtually all healthy volunteers. Sex and pubertal stage as well as urinary volume and clock times for collection periods should be registered when establishing a reference range for U-GH excretion and applying it for clinical purposes. Our reference values may be useful for further studies of patients with GH disorders.",
author = "Main, {K M} and M Jarden and L Angelo and Dinesen, {Birthe Irene} and Niels Hertel and A Juul and J M{\"u}ller and Skakkebaek, {N E}",
year = "1994",
language = "English",
volume = "79",
pages = "865--71",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - The impact of gender and puberty on reference values for urinary growth hormone excretion

T2 - a study of 3 morning urine samples in 517 healthy children and adults

AU - Main, K M

AU - Jarden, M

AU - Angelo, L

AU - Dinesen, Birthe Irene

AU - Hertel, Niels

AU - Juul, A

AU - Müller, J

AU - Skakkebaek, N E

PY - 1994

Y1 - 1994

N2 - Some recent studies have indicated that measurement of urinary GH (U-GH) excretion may be a useful tool for the evaluation of GH insufficiency in children with growth disorders, although some investigators are skeptical about the diagnostic value of U-GH. Most current assays are only available for specific laboratories or require time-intensive pretreatments of the specimens. This limits the possibility for many centers to compare their patients' data with others or to establish their own reference ranges for U-GH excretion. Therefore, we investigated the performance of a commercially available kit, which allows direct measurement of U-GH in untreated urine specimens. We established a reference range for the geometric mean of 3 morning urine samples in 446 healthy children and 71 adults. U-GH could be determined in all but 9 of 1526 samples (99.4%). U-GH excretion was significantly dependent on pubertal maturation (P <0.001) and sex (P <0.001), whereas age had no significant influence in the prepubertal group (P > 0.3). Peak values occurred in Tanner stages 3 and 4 (369 and 391 pg/h in females; 503 and 882 pg/h in males), corresponding to an age interval of 11-18 yr in boys and 9-15 yr in girls. Short collection periods (<6 h) were related to low values for U-GH excretion (nanograms per night; P <0.02). This time effect disappeared if U-GH excretion was expressed as picograms per h. If U-GH was related to creatinine output, there was a decrease in U-GH excretion during prepuberty, a blunting of the pubertal peak, and lower values in adults than in prepubertal children (P <0.0002). The intraindividual variation in U-GH excretion (picograms per h) ranged from 40-61%, constituting approximately two thirds of the interindividual variation. This variation was not lowered by relating U-GH to creatinine. We conclude that the assay was suitable for measurement of U-GH excretion in virtually all healthy volunteers. Sex and pubertal stage as well as urinary volume and clock times for collection periods should be registered when establishing a reference range for U-GH excretion and applying it for clinical purposes. Our reference values may be useful for further studies of patients with GH disorders.

AB - Some recent studies have indicated that measurement of urinary GH (U-GH) excretion may be a useful tool for the evaluation of GH insufficiency in children with growth disorders, although some investigators are skeptical about the diagnostic value of U-GH. Most current assays are only available for specific laboratories or require time-intensive pretreatments of the specimens. This limits the possibility for many centers to compare their patients' data with others or to establish their own reference ranges for U-GH excretion. Therefore, we investigated the performance of a commercially available kit, which allows direct measurement of U-GH in untreated urine specimens. We established a reference range for the geometric mean of 3 morning urine samples in 446 healthy children and 71 adults. U-GH could be determined in all but 9 of 1526 samples (99.4%). U-GH excretion was significantly dependent on pubertal maturation (P <0.001) and sex (P <0.001), whereas age had no significant influence in the prepubertal group (P > 0.3). Peak values occurred in Tanner stages 3 and 4 (369 and 391 pg/h in females; 503 and 882 pg/h in males), corresponding to an age interval of 11-18 yr in boys and 9-15 yr in girls. Short collection periods (<6 h) were related to low values for U-GH excretion (nanograms per night; P <0.02). This time effect disappeared if U-GH excretion was expressed as picograms per h. If U-GH was related to creatinine output, there was a decrease in U-GH excretion during prepuberty, a blunting of the pubertal peak, and lower values in adults than in prepubertal children (P <0.0002). The intraindividual variation in U-GH excretion (picograms per h) ranged from 40-61%, constituting approximately two thirds of the interindividual variation. This variation was not lowered by relating U-GH to creatinine. We conclude that the assay was suitable for measurement of U-GH excretion in virtually all healthy volunteers. Sex and pubertal stage as well as urinary volume and clock times for collection periods should be registered when establishing a reference range for U-GH excretion and applying it for clinical purposes. Our reference values may be useful for further studies of patients with GH disorders.

M3 - Journal article

VL - 79

SP - 865

EP - 871

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -

ID: 48486865