The opiate antagonist, naltrexone, in the treatment of trichotillomania: Results of a double-blind, placebo-controlled study

Research output: Contribution to journalJournal articleResearchpeer-review

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The opiate antagonist, naltrexone, in the treatment of trichotillomania : Results of a double-blind, placebo-controlled study. / Grant, Jon E; Odlaug, Brian Lawrence; Schreiber, Liana R N; Kim, Suck Won.

In: Journal of Clinical Psychopharmacology, Vol. 34, No. 1, 02.2014, p. 134-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Grant, JE, Odlaug, BL, Schreiber, LRN & Kim, SW 2014, 'The opiate antagonist, naltrexone, in the treatment of trichotillomania: Results of a double-blind, placebo-controlled study', Journal of Clinical Psychopharmacology, vol. 34, no. 1, pp. 134-8. https://doi.org/10.1097/JCP.0000000000000037

APA

Grant, J. E., Odlaug, B. L., Schreiber, L. R. N., & Kim, S. W. (2014). The opiate antagonist, naltrexone, in the treatment of trichotillomania: Results of a double-blind, placebo-controlled study. Journal of Clinical Psychopharmacology, 34(1), 134-8. https://doi.org/10.1097/JCP.0000000000000037

Vancouver

Grant JE, Odlaug BL, Schreiber LRN, Kim SW. The opiate antagonist, naltrexone, in the treatment of trichotillomania: Results of a double-blind, placebo-controlled study. Journal of Clinical Psychopharmacology. 2014 Feb;34(1):134-8. https://doi.org/10.1097/JCP.0000000000000037

Author

Grant, Jon E ; Odlaug, Brian Lawrence ; Schreiber, Liana R N ; Kim, Suck Won. / The opiate antagonist, naltrexone, in the treatment of trichotillomania : Results of a double-blind, placebo-controlled study. In: Journal of Clinical Psychopharmacology. 2014 ; Vol. 34, No. 1. pp. 134-8.

Bibtex

@article{8f8254bab7794876bfb1956bb7f796ca,
title = "The opiate antagonist, naltrexone, in the treatment of trichotillomania: Results of a double-blind, placebo-controlled study",
abstract = "Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone or placebo in an 8-week, double-blind trial. Subjects were assessed with measures of TTM severity and selected cognitive tasks. Naltrexone failed to demonstrate significantly greater reductions in hair pulling compared to placebo. Cognitive flexibility, however, significantly improved with naltrexone (P = 0.026). Subjects taking naltrexone with a family history of addiction showed a greater numerical reduction in the urges to pull, although it was not statistically significant. Future studies will have to examine whether pharmacological modulation of the opiate system may provide promise in controlling pulling behavior in a subgroup of individuals with TTM.",
author = "Grant, {Jon E} and Odlaug, {Brian Lawrence} and Schreiber, {Liana R N} and Kim, {Suck Won}",
year = "2014",
month = "2",
doi = "10.1097/JCP.0000000000000037",
language = "English",
volume = "34",
pages = "134--8",
journal = "Journal of Clinical Psychopharmacology",
issn = "0271-0749",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - The opiate antagonist, naltrexone, in the treatment of trichotillomania

T2 - Results of a double-blind, placebo-controlled study

AU - Grant, Jon E

AU - Odlaug, Brian Lawrence

AU - Schreiber, Liana R N

AU - Kim, Suck Won

PY - 2014/2

Y1 - 2014/2

N2 - Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone or placebo in an 8-week, double-blind trial. Subjects were assessed with measures of TTM severity and selected cognitive tasks. Naltrexone failed to demonstrate significantly greater reductions in hair pulling compared to placebo. Cognitive flexibility, however, significantly improved with naltrexone (P = 0.026). Subjects taking naltrexone with a family history of addiction showed a greater numerical reduction in the urges to pull, although it was not statistically significant. Future studies will have to examine whether pharmacological modulation of the opiate system may provide promise in controlling pulling behavior in a subgroup of individuals with TTM.

AB - Trichotillomania (TTM) is characterized by repetitive hair pulling resulting in hair loss. Data on the pharmacological treatment of TTM are limited. This study examined the opioid antagonist, naltrexone, in adults with TTM who had urges to pull their hair. Fifty-one individuals with TTM were randomized to naltrexone or placebo in an 8-week, double-blind trial. Subjects were assessed with measures of TTM severity and selected cognitive tasks. Naltrexone failed to demonstrate significantly greater reductions in hair pulling compared to placebo. Cognitive flexibility, however, significantly improved with naltrexone (P = 0.026). Subjects taking naltrexone with a family history of addiction showed a greater numerical reduction in the urges to pull, although it was not statistically significant. Future studies will have to examine whether pharmacological modulation of the opiate system may provide promise in controlling pulling behavior in a subgroup of individuals with TTM.

U2 - 10.1097/JCP.0000000000000037

DO - 10.1097/JCP.0000000000000037

M3 - Journal article

C2 - 24145220

VL - 34

SP - 134

EP - 138

JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

SN - 0271-0749

IS - 1

ER -

ID: 103014659