The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients

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A Juul, K Main, W F Blum, Jesper Lindholm, M B Ranke, N E Skakkebaek

Several in-vitro studies have suggested that the biological actions of IGF-I can be modified by the presence of specific IGF binding proteins. In man, the 24-hour serum levels of IGF-I and IGFBP-3 remain constant, but short-term changes in the IGF-I/IGFBP-3 ratio have been described following GH administration. Serum levels of IGF-I and IGFBP-3 decrease with age in normal adults and are elevated in active acromegaly due to excessive GH secretion. However, the individual ratios between serum levels of IGF-I and IGFBP-3 in acromegalic and healthy adults have not been described previously.
Original languageEnglish
JournalClinical Endocrinology
Volume41
Issue number1
Pages (from-to)85-93
Number of pages9
ISSN0300-0664
Publication statusPublished - 1994

ID: 48486888