Tobacco Smoking and Risk of Second Primary Lung Cancer

Research output: Contribution to journalJournal articlepeer-review

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Tobacco Smoking and Risk of Second Primary Lung Cancer. / Aredo, Jacqueline V.; Luo, Sophia J.; Gardner, Rebecca M.; Sanyal, Nilotpal; Choi, Eunji; Hickey, Thomas P.; Riley, Thomas L.; Huang, Wen-Yi; Kurian, Allison W.; Leung, Ann N.; Wilkens, Lynne R.; Robbins, Hilary A.; Riboli, Elio; Kaaks, Rudolf; Tjonneland, Anne; Vermeulen, Roel C. H.; Panico, Salvatore; Marchand, Loic Le; Amos, Christopher I.; Hung, Rayjean J.; Freedman, Neal D.; Johansson, Mattias; Cheng, Iona; Wakelee, Heather A.; Han, Summer S.

In: Journal of Thoracic Oncology, Vol. 16, No. 6, 2021, p. 968-979.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Aredo, JV, Luo, SJ, Gardner, RM, Sanyal, N, Choi, E, Hickey, TP, Riley, TL, Huang, W-Y, Kurian, AW, Leung, AN, Wilkens, LR, Robbins, HA, Riboli, E, Kaaks, R, Tjonneland, A, Vermeulen, RCH, Panico, S, Marchand, LL, Amos, CI, Hung, RJ, Freedman, ND, Johansson, M, Cheng, I, Wakelee, HA & Han, SS 2021, 'Tobacco Smoking and Risk of Second Primary Lung Cancer', Journal of Thoracic Oncology, vol. 16, no. 6, pp. 968-979. https://doi.org/10.1016/j.jtho.2021.02.024

APA

Aredo, J. V., Luo, S. J., Gardner, R. M., Sanyal, N., Choi, E., Hickey, T. P., Riley, T. L., Huang, W-Y., Kurian, A. W., Leung, A. N., Wilkens, L. R., Robbins, H. A., Riboli, E., Kaaks, R., Tjonneland, A., Vermeulen, R. C. H., Panico, S., Marchand, L. L., Amos, C. I., ... Han, S. S. (2021). Tobacco Smoking and Risk of Second Primary Lung Cancer. Journal of Thoracic Oncology, 16(6), 968-979. https://doi.org/10.1016/j.jtho.2021.02.024

Vancouver

Aredo JV, Luo SJ, Gardner RM, Sanyal N, Choi E, Hickey TP et al. Tobacco Smoking and Risk of Second Primary Lung Cancer. Journal of Thoracic Oncology. 2021;16(6):968-979. https://doi.org/10.1016/j.jtho.2021.02.024

Author

Aredo, Jacqueline V. ; Luo, Sophia J. ; Gardner, Rebecca M. ; Sanyal, Nilotpal ; Choi, Eunji ; Hickey, Thomas P. ; Riley, Thomas L. ; Huang, Wen-Yi ; Kurian, Allison W. ; Leung, Ann N. ; Wilkens, Lynne R. ; Robbins, Hilary A. ; Riboli, Elio ; Kaaks, Rudolf ; Tjonneland, Anne ; Vermeulen, Roel C. H. ; Panico, Salvatore ; Marchand, Loic Le ; Amos, Christopher I. ; Hung, Rayjean J. ; Freedman, Neal D. ; Johansson, Mattias ; Cheng, Iona ; Wakelee, Heather A. ; Han, Summer S. / Tobacco Smoking and Risk of Second Primary Lung Cancer. In: Journal of Thoracic Oncology. 2021 ; Vol. 16, No. 6. pp. 968-979.

Bibtex

@article{de24bfdd22bf4bedad4d6f622cd49bc7,
title = "Tobacco Smoking and Risk of Second Primary Lung Cancer",
abstract = "Introduction: Lung cancer survivors are at high risk of developing a second primary lung cancer (SPLC). However, SPLC risk factors have not been established and the impact of tobacco smoking remains controversial. We examined the risk factors for SPLC across multiple epidemiologic cohorts and evaluated the impact of smoking cessation on reducing SPLC risk.Methods: We analyzed data from 7059 participants in the Multiethnic Cohort (MEC) diagnosed with an initial primary lung cancer (IPLC) between 1993 and 2017. Cause-specific proportional hazards models estimated SPLC risk. We conducted validation studies using the Prostate, Lung,Colorectal, and Ovarian Cancer Screening Trial (N = 3423 IPLC cases) and European Prospective Investigation into Cancer and Nutrition (N = 4731 IPLC cases) cohorts and pooled the SPLC risk estimates using random effects meta analysis.Results: Overall, 163 MEC cases (2.3%) developed SPLC. Smoking pack-years (hazard ratio [HR] = 1.18 per 10 pack years, p < 0.001) and smoking intensity (HR = 1.30 per 10 cigarettes per day, p < 0.001) were significantly associated with increased SPLC risk. Individuals who met the 2013 U.S. Preventive Services Task Force's screening criteria at IPLC diagnosis also had an increased SPLC risk (HR = 1.92; p < 0.001). Validation studies with the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and European Prospective Investigation into Cancer and Nutrition revealed consistent results. Meta-analysis yielded pooled HRs of 1.16 per 10 pack-years (p(meta) < 0.001), 1.25 per 10 cigarettes per day (p(meta) < 0.001), and 1.99 (p(meta) < 0.001) for meeting the U.S. Preventive Services Task Force's criteria. In MEC, smoking cessation after IPLC diagnosis was associated with an 83% reduction in SPLC risk (HR = 0.17; p < 0.001).Conclusions: Tobacco smoking is a risk factor for SPLC. Smoking cessation may reduce the risk of SPLC. Additional strategies for SPLC surveillance and screening are warranted. (C) 2021 International Association for the Study of Lung Cancer. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",
keywords = "Second primary lung cancer, Tobacco smoking, Smoking cessation, Surveillance, Screening, HISTORY, EPIDEMIOLOGY, RESECTION, SURVIVAL, OUTCOMES, MODEL",
author = "Aredo, {Jacqueline V.} and Luo, {Sophia J.} and Gardner, {Rebecca M.} and Nilotpal Sanyal and Eunji Choi and Hickey, {Thomas P.} and Riley, {Thomas L.} and Wen-Yi Huang and Kurian, {Allison W.} and Leung, {Ann N.} and Wilkens, {Lynne R.} and Robbins, {Hilary A.} and Elio Riboli and Rudolf Kaaks and Anne Tjonneland and Vermeulen, {Roel C. H.} and Salvatore Panico and Marchand, {Loic Le} and Amos, {Christopher I.} and Hung, {Rayjean J.} and Freedman, {Neal D.} and Mattias Johansson and Iona Cheng and Wakelee, {Heather A.} and Han, {Summer S.}",
year = "2021",
doi = "10.1016/j.jtho.2021.02.024",
language = "English",
volume = "16",
pages = "968--979",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Tobacco Smoking and Risk of Second Primary Lung Cancer

AU - Aredo, Jacqueline V.

AU - Luo, Sophia J.

AU - Gardner, Rebecca M.

AU - Sanyal, Nilotpal

AU - Choi, Eunji

AU - Hickey, Thomas P.

AU - Riley, Thomas L.

AU - Huang, Wen-Yi

AU - Kurian, Allison W.

AU - Leung, Ann N.

AU - Wilkens, Lynne R.

AU - Robbins, Hilary A.

AU - Riboli, Elio

AU - Kaaks, Rudolf

AU - Tjonneland, Anne

AU - Vermeulen, Roel C. H.

AU - Panico, Salvatore

AU - Marchand, Loic Le

AU - Amos, Christopher I.

AU - Hung, Rayjean J.

AU - Freedman, Neal D.

AU - Johansson, Mattias

AU - Cheng, Iona

AU - Wakelee, Heather A.

AU - Han, Summer S.

PY - 2021

Y1 - 2021

N2 - Introduction: Lung cancer survivors are at high risk of developing a second primary lung cancer (SPLC). However, SPLC risk factors have not been established and the impact of tobacco smoking remains controversial. We examined the risk factors for SPLC across multiple epidemiologic cohorts and evaluated the impact of smoking cessation on reducing SPLC risk.Methods: We analyzed data from 7059 participants in the Multiethnic Cohort (MEC) diagnosed with an initial primary lung cancer (IPLC) between 1993 and 2017. Cause-specific proportional hazards models estimated SPLC risk. We conducted validation studies using the Prostate, Lung,Colorectal, and Ovarian Cancer Screening Trial (N = 3423 IPLC cases) and European Prospective Investigation into Cancer and Nutrition (N = 4731 IPLC cases) cohorts and pooled the SPLC risk estimates using random effects meta analysis.Results: Overall, 163 MEC cases (2.3%) developed SPLC. Smoking pack-years (hazard ratio [HR] = 1.18 per 10 pack years, p < 0.001) and smoking intensity (HR = 1.30 per 10 cigarettes per day, p < 0.001) were significantly associated with increased SPLC risk. Individuals who met the 2013 U.S. Preventive Services Task Force's screening criteria at IPLC diagnosis also had an increased SPLC risk (HR = 1.92; p < 0.001). Validation studies with the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and European Prospective Investigation into Cancer and Nutrition revealed consistent results. Meta-analysis yielded pooled HRs of 1.16 per 10 pack-years (p(meta) < 0.001), 1.25 per 10 cigarettes per day (p(meta) < 0.001), and 1.99 (p(meta) < 0.001) for meeting the U.S. Preventive Services Task Force's criteria. In MEC, smoking cessation after IPLC diagnosis was associated with an 83% reduction in SPLC risk (HR = 0.17; p < 0.001).Conclusions: Tobacco smoking is a risk factor for SPLC. Smoking cessation may reduce the risk of SPLC. Additional strategies for SPLC surveillance and screening are warranted. (C) 2021 International Association for the Study of Lung Cancer. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

AB - Introduction: Lung cancer survivors are at high risk of developing a second primary lung cancer (SPLC). However, SPLC risk factors have not been established and the impact of tobacco smoking remains controversial. We examined the risk factors for SPLC across multiple epidemiologic cohorts and evaluated the impact of smoking cessation on reducing SPLC risk.Methods: We analyzed data from 7059 participants in the Multiethnic Cohort (MEC) diagnosed with an initial primary lung cancer (IPLC) between 1993 and 2017. Cause-specific proportional hazards models estimated SPLC risk. We conducted validation studies using the Prostate, Lung,Colorectal, and Ovarian Cancer Screening Trial (N = 3423 IPLC cases) and European Prospective Investigation into Cancer and Nutrition (N = 4731 IPLC cases) cohorts and pooled the SPLC risk estimates using random effects meta analysis.Results: Overall, 163 MEC cases (2.3%) developed SPLC. Smoking pack-years (hazard ratio [HR] = 1.18 per 10 pack years, p < 0.001) and smoking intensity (HR = 1.30 per 10 cigarettes per day, p < 0.001) were significantly associated with increased SPLC risk. Individuals who met the 2013 U.S. Preventive Services Task Force's screening criteria at IPLC diagnosis also had an increased SPLC risk (HR = 1.92; p < 0.001). Validation studies with the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and European Prospective Investigation into Cancer and Nutrition revealed consistent results. Meta-analysis yielded pooled HRs of 1.16 per 10 pack-years (p(meta) < 0.001), 1.25 per 10 cigarettes per day (p(meta) < 0.001), and 1.99 (p(meta) < 0.001) for meeting the U.S. Preventive Services Task Force's criteria. In MEC, smoking cessation after IPLC diagnosis was associated with an 83% reduction in SPLC risk (HR = 0.17; p < 0.001).Conclusions: Tobacco smoking is a risk factor for SPLC. Smoking cessation may reduce the risk of SPLC. Additional strategies for SPLC surveillance and screening are warranted. (C) 2021 International Association for the Study of Lung Cancer. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

KW - Second primary lung cancer

KW - Tobacco smoking

KW - Smoking cessation

KW - Surveillance

KW - Screening

KW - HISTORY

KW - EPIDEMIOLOGY

KW - RESECTION

KW - SURVIVAL

KW - OUTCOMES

KW - MODEL

U2 - 10.1016/j.jtho.2021.02.024

DO - 10.1016/j.jtho.2021.02.024

M3 - Journal article

C2 - 33722709

VL - 16

SP - 968

EP - 979

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

SN - 1556-0864

IS - 6

ER -

ID: 270715288