Treatment of Plasmodium falciparum malaria with mefloquine alone or in combination with i.v. quinine at the Department of Communicable and Tropical Diseases, Rigshospitalet, Copenhagen 1982-1988

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Treatment of Plasmodium falciparum malaria with mefloquine alone or in combination with i.v. quinine at the Department of Communicable and Tropical Diseases, Rigshospitalet, Copenhagen 1982-1988. / Magnussen, P; Bygbjerg, Ib Christian.

In: Danish Medical Bulletin (Online), Vol. 37, No. 6, 01.12.1990, p. 563-4.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Magnussen, P & Bygbjerg, IC 1990, 'Treatment of Plasmodium falciparum malaria with mefloquine alone or in combination with i.v. quinine at the Department of Communicable and Tropical Diseases, Rigshospitalet, Copenhagen 1982-1988', Danish Medical Bulletin (Online), vol. 37, no. 6, pp. 563-4.

APA

Magnussen, P., & Bygbjerg, I. C. (1990). Treatment of Plasmodium falciparum malaria with mefloquine alone or in combination with i.v. quinine at the Department of Communicable and Tropical Diseases, Rigshospitalet, Copenhagen 1982-1988. Danish Medical Bulletin (Online), 37(6), 563-4.

Vancouver

Magnussen P, Bygbjerg IC. Treatment of Plasmodium falciparum malaria with mefloquine alone or in combination with i.v. quinine at the Department of Communicable and Tropical Diseases, Rigshospitalet, Copenhagen 1982-1988. Danish Medical Bulletin (Online). 1990 Dec 1;37(6):563-4.

Author

Magnussen, P ; Bygbjerg, Ib Christian. / Treatment of Plasmodium falciparum malaria with mefloquine alone or in combination with i.v. quinine at the Department of Communicable and Tropical Diseases, Rigshospitalet, Copenhagen 1982-1988. In: Danish Medical Bulletin (Online). 1990 ; Vol. 37, No. 6. pp. 563-4.

Bibtex

@article{f357fb03d17a4102a677cad869ef0314,
title = "Treatment of Plasmodium falciparum malaria with mefloquine alone or in combination with i.v. quinine at the Department of Communicable and Tropical Diseases, Rigshospitalet, Copenhagen 1982-1988",
abstract = "At the Department of Communicable and Tropical Diseases, Rigshospitalet, Denmark, mefloquine has been used since 1982 for the treatment of patients with suspected or verified chloroquine and sulfadoxine-pyrimethamine resistant P. falciparum malaria. Eighty-one patients treated with mefloquine are reviewed. Forty patients had complicated malaria; 18 were initially treated with IV quinine. Mefloquine dose for adults was 1,500 mg in one dose or divided in two with six hourly intervals. Mild gastrointestinal side effects were common; in 10 patients, the medication had to be repeated because of vomiting. No neurological or neuropsychiatric side effects were recorded in relation to treatment or during the follow up period (30 days). Temperature subsided with a mean of 2.7 days after initiation of treatment and trophozoites cleared with a mean of 3.6 days. One patient had recrudescence. Mefloquine is found safe and effective for the treatment of P. falciparum malaria and is recommended for treatment of worldwide acquired P. falciparum malaria, although patients should be monitored closely to disclose resistance.",
keywords = "Adolescent, Adult, Aged, Animals, Child, Child, Preschool, Denmark, Drug Therapy, Combination, Follow-Up Studies, Humans, Infant, Malaria, Mefloquine, Middle Aged, Plasmodium falciparum, Quinine",
author = "P Magnussen and Bygbjerg, {Ib Christian}",
year = "1990",
month = dec,
day = "1",
language = "English",
volume = "37",
pages = "563--4",
journal = "Danish Medical Journal",
issn = "1603-9629",
publisher = "Almindelige Danske Laegeforening",
number = "6",

}

RIS

TY - JOUR

T1 - Treatment of Plasmodium falciparum malaria with mefloquine alone or in combination with i.v. quinine at the Department of Communicable and Tropical Diseases, Rigshospitalet, Copenhagen 1982-1988

AU - Magnussen, P

AU - Bygbjerg, Ib Christian

PY - 1990/12/1

Y1 - 1990/12/1

N2 - At the Department of Communicable and Tropical Diseases, Rigshospitalet, Denmark, mefloquine has been used since 1982 for the treatment of patients with suspected or verified chloroquine and sulfadoxine-pyrimethamine resistant P. falciparum malaria. Eighty-one patients treated with mefloquine are reviewed. Forty patients had complicated malaria; 18 were initially treated with IV quinine. Mefloquine dose for adults was 1,500 mg in one dose or divided in two with six hourly intervals. Mild gastrointestinal side effects were common; in 10 patients, the medication had to be repeated because of vomiting. No neurological or neuropsychiatric side effects were recorded in relation to treatment or during the follow up period (30 days). Temperature subsided with a mean of 2.7 days after initiation of treatment and trophozoites cleared with a mean of 3.6 days. One patient had recrudescence. Mefloquine is found safe and effective for the treatment of P. falciparum malaria and is recommended for treatment of worldwide acquired P. falciparum malaria, although patients should be monitored closely to disclose resistance.

AB - At the Department of Communicable and Tropical Diseases, Rigshospitalet, Denmark, mefloquine has been used since 1982 for the treatment of patients with suspected or verified chloroquine and sulfadoxine-pyrimethamine resistant P. falciparum malaria. Eighty-one patients treated with mefloquine are reviewed. Forty patients had complicated malaria; 18 were initially treated with IV quinine. Mefloquine dose for adults was 1,500 mg in one dose or divided in two with six hourly intervals. Mild gastrointestinal side effects were common; in 10 patients, the medication had to be repeated because of vomiting. No neurological or neuropsychiatric side effects were recorded in relation to treatment or during the follow up period (30 days). Temperature subsided with a mean of 2.7 days after initiation of treatment and trophozoites cleared with a mean of 3.6 days. One patient had recrudescence. Mefloquine is found safe and effective for the treatment of P. falciparum malaria and is recommended for treatment of worldwide acquired P. falciparum malaria, although patients should be monitored closely to disclose resistance.

KW - Adolescent

KW - Adult

KW - Aged

KW - Animals

KW - Child

KW - Child, Preschool

KW - Denmark

KW - Drug Therapy, Combination

KW - Follow-Up Studies

KW - Humans

KW - Infant

KW - Malaria

KW - Mefloquine

KW - Middle Aged

KW - Plasmodium falciparum

KW - Quinine

M3 - Journal article

C2 - 2073860

VL - 37

SP - 563

EP - 564

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 1603-9629

IS - 6

ER -

ID: 33890923