Urinary phthalate concentrations in mothers and their children in Ireland: Results of the DEMOCOPHES human biomonitoring study
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Urinary phthalate concentrations in mothers and their children in Ireland : Results of the DEMOCOPHES human biomonitoring study. / Cullen, Elizabeth; Evans, David; Griffin, Chris; Burke, Padraig; Mannion, Rory; Burns, Damien; Flanagan, Andrew; Kellegher, Ann; Schoeters, Greet; Govarts, Eva; Biot, Pierre; Casteleyn, Ludwine; Castaño, Argelia; Kolossa-Gehring, Marike; Esteban, Marta; Schwedler, Gerda; Koch, Holger M.; Angerer, Jürgen; Knudsen, Lisbeth E.; Joas, Reinhard; Joas, Anke; Dumez, Birgit; Sepai, Ovnair; Exley, Karen; Aerts, Dominique.
In: International Journal of Environmental Research and Public Health, Vol. 14, No. 12, 1456, 12.2017, p. 1-12.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Urinary phthalate concentrations in mothers and their children in Ireland
T2 - Results of the DEMOCOPHES human biomonitoring study
AU - Cullen, Elizabeth
AU - Evans, David
AU - Griffin, Chris
AU - Burke, Padraig
AU - Mannion, Rory
AU - Burns, Damien
AU - Flanagan, Andrew
AU - Kellegher, Ann
AU - Schoeters, Greet
AU - Govarts, Eva
AU - Biot, Pierre
AU - Casteleyn, Ludwine
AU - Castaño, Argelia
AU - Kolossa-Gehring, Marike
AU - Esteban, Marta
AU - Schwedler, Gerda
AU - Koch, Holger M.
AU - Angerer, Jürgen
AU - Knudsen, Lisbeth E.
AU - Joas, Reinhard
AU - Joas, Anke
AU - Dumez, Birgit
AU - Sepai, Ovnair
AU - Exley, Karen
AU - Aerts, Dominique
PY - 2017/12
Y1 - 2017/12
N2 - Background: Phthalates are chemicals which are widespread in the environment. Although the impacts on health of such exposure are unclear, there is evidence of a possible impact on the incidence of a diverse range of diseases. Monitoring of human exposure to phthalates is therefore important. This study aimed to determine the extent of phthalate exposure among mothers and their children in both rural and urban areas in Ireland, and to identify factors associated with elevated concentrations. It formed part of the ‘Demonstration of a study to Co-ordinate and Perform Human Biomonitoring on a European Scale’ (DEMOCOPHES) pilot biomonitoring study. Methods: the concentration of phthalate metabolites were determined from a convenience sample of 120 mother/child pairs. The median age of the children was 8 years. A questionnaire was used to collect information regarding lifestyle and environmental conditions of the children and mothers. Rigorous quality assurance within DEMOCOPHES guaranteed the accuracy and international comparability of results. Results: Phthalate metabolites were detected in all of the samples from both children and mothers. Concentrations were significantly higher in respondents from families with lower educational attainment and in those exposed to such items as polyvinyl chloride (PVC), fast food and personal care products (PCP). Conclusions: The study demonstrates that human biomonitoring for assessing exposure to phthalates can be undertaken in Ireland and that the exposure of the population is widespread. Further work will be necessary before the consequences of this exposure are understood.
AB - Background: Phthalates are chemicals which are widespread in the environment. Although the impacts on health of such exposure are unclear, there is evidence of a possible impact on the incidence of a diverse range of diseases. Monitoring of human exposure to phthalates is therefore important. This study aimed to determine the extent of phthalate exposure among mothers and their children in both rural and urban areas in Ireland, and to identify factors associated with elevated concentrations. It formed part of the ‘Demonstration of a study to Co-ordinate and Perform Human Biomonitoring on a European Scale’ (DEMOCOPHES) pilot biomonitoring study. Methods: the concentration of phthalate metabolites were determined from a convenience sample of 120 mother/child pairs. The median age of the children was 8 years. A questionnaire was used to collect information regarding lifestyle and environmental conditions of the children and mothers. Rigorous quality assurance within DEMOCOPHES guaranteed the accuracy and international comparability of results. Results: Phthalate metabolites were detected in all of the samples from both children and mothers. Concentrations were significantly higher in respondents from families with lower educational attainment and in those exposed to such items as polyvinyl chloride (PVC), fast food and personal care products (PCP). Conclusions: The study demonstrates that human biomonitoring for assessing exposure to phthalates can be undertaken in Ireland and that the exposure of the population is widespread. Further work will be necessary before the consequences of this exposure are understood.
KW - Endocrine disruptors
KW - Exposure
KW - Human biomonitoring
KW - Phthalates
UR - http://www.scopus.com/inward/record.url?scp=85036533494&partnerID=8YFLogxK
U2 - 10.3390/ijerph14121456
DO - 10.3390/ijerph14121456
M3 - Journal article
C2 - 29186834
AN - SCOPUS:85036533494
VL - 14
SP - 1
EP - 12
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 12
M1 - 1456
ER -
ID: 188444890